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Coagulation factor VII

Brief Information

Name:Coagulation factor VII
Target Synonym:Proconvertin,Serum prothrombin conversion accelerator,F7,Coagulation Factor VII,Coagulation Factor VII (Serum Prothrombin Conversion Accelerator),FVII Coagulation Protein,SPCA,EC 3.4.21.21,Factor VII,EC:3.4.21.21,EC 3.4.21,Eptacog alfa
Number of Launched Drugs:12
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
TF7-H52H5 Human Human Coagulation factor VII / F7 Protein, His Tag (active enzyme, MALS verified)
TF7-H52H5-structure
TF7-H52H5-sds

Part of Bioactivity data

TF7-H52H5-ELISA
Human Coagulation factor VII, His Tag (Cat. No. ) MALS images

The purity of Human Coagulation factor VII, His Tag (Cat. No. TF7-H52H5) was more than 85% and the molecular weight of this protein is around 55-65 kDa verified by SEC-MALS.

Bioactivity

Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC. The specific activity is >80 pmol/min/µg, as measured under the described conditions (QC tested).

Synonym Name

Coagulation factor VII,F7,SPCA,Proconvertin

Background

Coagulation factor VII is also known as F7, SPCA and Proconvertin. Heterodimer of a light chain and a heavy chain linked by a disulfide bond. Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Prothrombin complex concentrat (Taibang Biological Products) Approved Shandong Taibang Biological Products Co Ltd Mainland China Hemorrhage Shandong Taibang Biological Products Co Ltd 2014-09-30 Hemorrhage; Antithrombin III Deficiency Details
Human prothrombin complex (Hualan Biological Engineering) Approved Hualan Genetic Engineering Co Ltd Mainland China Blood Coagulation Disorders null 1999-01-01 Blood Coagulation Disorders; Hemophilia B; Factor X Deficiency Details
Prothrombin complex concentrate (Sanquin) Approved Sanquin Plasma Products Bv Cofact Hemorrhage Sanquin Plasma Products Bv 2007-11-01 Hemorrhage Details
Factor IX complex (Grifols) Approved Grifols Sa Profilnine United States Hemophilia B null 1981-07-21 Hemophilia B Details
Human prothrombin complex (LFB) Approved Lfb Biotechnologies KANOKAD France Hemorrhage Lfb Biotechnologies 2008-09-01 Hemorrhage Details
Human prothrombin complex (CSL Behring) BE-1116 Approved Csl Behring Llc Kcentra, Beriplex, Confidex Coagulation Protein Disorders; Blood Coagulation Disorders; Hemorrhage; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Details
Human prothrombin complex concentrate (Guizhou Taibang Biological Products) Approved Guizhou Taibang Biological Products Co Ltd Mainland China Hypoprothrombinemias Guizhou Taibang Biological Products Co Ltd 2013-07-31 Hypoprothrombinemias Details
Prothrombinex-VF (CSL Behring) Approved Csl Behring Llc Australia Hemorrhage Csl Behring Llc 2014-10-01 Hemorrhage Details
Human prothrombin complex concentrate (Shanxi Kangbao Biological Products) Approved Shanxi Kangbao Biological Product Co Ltd Mainland China Hemorrhage Shanxi Kangbao Biological Product Co Ltd 2019-09-17 Hemorrhage Details
Human prothrombin complex (Shanghai Xinxing) Approved Shanghai Xinxing Medicine Co Ltd Mainland China Hemorrhage Shanghai Xinxing Medicine Co Ltd 1997-01-01 Hemorrhage Details
Human prothrombin complex (Sinopharm Shanghai Plasma) Approved Sinopharm Shanghai Plasma-Derived Biotherapies Co Ltd Mainland China Hemorrhage Sinopharm Shanghai Plasma-Derived Biotherapies Co Ltd 1997-01-01 Hemorrhage Details
Human prothrombin complex (Boya Bio-Pharmaceutical) Approved Boya Bio-Pharmaceutical Group Co Ltd Mainland China Hemorrhage Boya Bio-Pharmaceutical Group Co Ltd 2020-12-02 Hemorrhage Details
Human prothrombin complex (Guangdong Wellen) Approved Guangdong Wellen Pharmaceutical Co Ltd Mainland China Hemorrhage Guangdong Wellen Pharmaceutical Co Ltd 2020-10-21 Hemorrhage Details
Human prothrombin complex (Tonrol Biopharmaceuticals) Approved Tonrol Bio-Pharmaceutical Co Ltd ProthoRAAS Mainland China Hemorrhage Shanghai Raas Blood Products Co Ltd 1996-01-01 Hemophilia B; Hemorrhage Details
Anti-inhibitor coagulant complex (Baxalta) Approved Baxalta Feiba, Prothromplex TOTAL Japan Hemophilia A; Hemophilia B Baxalta 1979-12-21 Hemophilia A; Blood Coagulation Disorders, Inherited; Hemophilia B Details
Human prothrombin complex (Octapharma) Approved Octapharma Ocplex, Octaplex, Pronativ United Kingdom Hemorrhage Octapharma 2003-03-14 Hemorrhage; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Human prothrombin complex concentrate (Harbin Shiheng Bioengineering Pharmaceutical) Phase 3 Clinical Harbin Pacific Biopharmaceutical Co Ltd Hemophilia B Details
Human prothrombin complex concentrate (Sichuan Yuanda Shuyang Pharmaceutical) Phase 3 Clinical Sichuan Yuanda Shuyang Pharmaceutical Co Ltd Blood Coagulation Disorders Details
TT-173 Phase 3 Clinical Thrombotargets Blood Coagulation Disorders; Burns; Osteoarthritis Details
Human prothrombin complex (Lanzhou Lansheng Blood Products) Phase 3 Clinical Lanzhou Lansheng Blood Products Co Ltd Hemophilia B Details
Factor VII (KM Biologics) KD2-305 Phase 3 Clinical Km Biologics Hemophilia A Details

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