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Your Position: Home > Nucleolin


Brief Information

Target Synonym:NCL,Nucleolin,Protein C23,Nsr1,C23
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Approved

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Synonym Name

Nucleolin,NCL,Protein C23


Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Recombinant human endostatin (Simcere) YH-16 Approved Jiangsu Simcere Pharmaceutical Co Ltd Endostar, 恩度, Endu Mainland China Carcinoma, Non-Small-Cell Lung Shandong Simcere Bio-Pharmaceutical Co Ltd 2005-09-12 Head and Neck Neoplasms; Esophageal Neoplasms; Ascites; Osteosarcoma; Nasopharyngeal Carcinoma; Brain metastases; Pleural Effusion, Malignant; Carcinoma, Non-Small-Cell Lung Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
IPP-204106 N6L; Nucant-6L; IPP-204106; IPP-204106N; poyplexed IPP-204106 Phase 2 Clinical Immupharma Plc Solid tumours; Neoplasms Details
AS-1411 AGRO-100; GR-026-B; AS-1411; ACT-GRO-777 Phase 2 Clinical University Of Louisville, Antisoma, University Of Alabama At Birmingham Solid tumours; Neoplasms Details
Pegylated recombinant human endostatin (Tsinghua University) M-2ES; CRB-0401 Phase 1 Clinical Tsinghua University, Beijing Protgen Biotechnology Development Co Ltd, Beijing Proji Pharmaceutical Technology Co Ltd Solid tumours; Pancreatic Neoplasms; Neoplasms; Carcinoma, Non-Small-Cell Lung Details
APTA-16 APTA-16; SJP1604 Phase 1 Clinical Aptabio Therapeutics Inc Liver Neoplasms; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details

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