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Your Position: Home > Integrin isoform alpha-7X1B beta 1

Integrin isoform alpha-7X1B beta 1

Brief Information

Name:Integrin beta-1
Target Synonym:GPIIA,VLA-4 subunit beta,CD_antigen: CD29,CD29,Integrin Subunit Beta 1,Integrin, Beta 1,Integrin Beta 1,Integrin VLA-4 Beta Subunit,Fibronectin receptor subunit beta,Glycoprotein IIa
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
IT1-C52W3 Cynomolgus Cynomolgus Integrin isoform alpha-7X1B beta 1 (ITGA7X1B&ITGB1) Heterodimer Protein, Tag Free&His Tag (MALS verified)
IT1-C52W3-structure
IT1-C52W3-sds
ACRO Quality

Part of Bioactivity data

IT1-C52W3-MALS-HPLC
Integrin isoform alpha-7X1B beta 1 MALS images

The purity of Cynomolgus ITGA7X1B&ITGB1 Heterodimer Protein, Tag Free&His Tag (Cat. No. IT1-C52W3) is more than 90% and the molecular weight of this protein is around 210-250 kDa verified by SEC-MALS.

Synonym Name

integrin alpha-7 isoform X1B beta 1,ITGA7X1B&ITGB1,ITGA7X1BB1

Background

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
OS-2966 OS2966t; OS-2966; OS2966 Phase 1 Clinical OncoSynergy Inc Brain Injuries, Traumatic; Glioblastoma; Psoriasis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Astrocytoma; Glioma; Leukemia, Myeloid, Acute Details

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