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Integrin isoform alpha-7X1B beta 1

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Cat. No. Species Product Description Structure Purity Feature
IT1-C52W3 Cynomolgus Cynomolgus Integrin isoform alpha-7X1B beta 1 (ITGA7X1B&ITGB1) Heterodimer Protein, Tag Free&His Tag (MALS verified)
IT1-C52W3-structure
IT1-C52W3-sds

Part of Bioactivity data

IT1-C52W3-ELISA
Cynomolgus ITGA7X1B&ITGB1 Heterodimer Protein, Tag Free&His Tag (Cat. No. ) MALS images

The purity of Cynomolgus ITGA7X1B&ITGB1 Heterodimer Protein, Tag Free&His Tag (Cat. No. IT1-C52W3) was more than 90% and the molecular weight of this protein is around 208-254 kDa verified by SEC-MALS.

  • Background
    Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.
  • Clinical and Translational Updates
      
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Synonym Name

integrin alpha-7 isoform X1B beta 1,ITGA7X1B&ITGB1,ITGA7X1BB1

Background

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.

Clinical and Translational Updates

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