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Your Position: Home > LRRC32 & TGF-beta 1

LRRC32 & TGF-beta 1

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Part of Bioactivity data

GA1-C52W7-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-LRRC32 antibody captured on Protein A Chip can bind Cynomolgus LRRC32&TGF-beta 1 Heterotrimer Protein, His Tag&Tag Free (Cat. No. GA1-C52W7) with an affinity constant of 51.9 pM as determined in SPR assay (Biacore 8K) (Routinely tested).

GA1-M52W2-ELISA
Mouse LRRC32&TGFB1 Heterotrimer protein, His Tag&Tag FreeMouse LRRC32&TGFB1 Heterotrimer protein, His Tag&Tag Free (Cat. No. GA1-M52W2) ELISA bioactivity

Immobilized Mouse LRRC32&TGFB1 Heterotrimer protein, His Tag&Tag Free at 1 μg/mL (100 μL/well) can bind Purified anti-mouse LAP (TGF-β1) Antibody with a linear range of 0.2-1 ng/mL (QC tested).

Synonym Name

LRRC32 & TGF-beta 1,LRRC32&TGFB1

Background

GARP (LRRC32) is a transmembrane protein that binds latent-TGF-β1 and tethers it on the Treg surface. and has been proved to promote the activation and secretion of transforming growth factor β (TGF-β). The expression of GARP is highly on the surface activated Tregs and increases the suppressive function of Tregs. Additionally, GARP can bind to latent transforming growth factor β (TGF-β), thus promoting secretion and activation of TGF-β. TGF-β plays a critical rule for homeostasis and function of Tregs. Notably, it has been also observed that fibroblasts and endothelial cell lines that express GARP/latent TGF-β1 complexes do not activate TGF-β1. However, it cannot be excluded that specific stimuli are required to trigger TGF-β1 activation from complexes on the surface of these cell types.

Clinical and Translational Updates

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