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BMPR-1A

Brief Information

Name:Bone morphogenetic protein receptor type-1A
Target Synonym:Bone Morphogenetic Protein Receptor Type 1A,EC 2.7.11,Activin receptor-like kinase 3,Bone morphogenetic protein receptor type-1A,ALK3,BMPR1A,Bone Morphogenetic Protein Receptor, Type IA,Serine/Threonine-Protein Kinase Receptor R5,ACVRLK3,BMPR-1A,SKR5,Activin A Receptor, Type II-Like Kinase 3,CD292 Antigen,EC 2.7.11.30,10q23del,CD292,BMP type-1A receptor,ALK-3,EC:2.7.11.30
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
AL3-H52H9 Human Human BMPR-1A / ALK-3 Protein, His Tag (MALS verified)
AL3-H52H9-structure
AL3-H52H9-sds
AL3-H5259 Human Human BMPR-1A / ALK-3 Protein, Fc Tag
AL3-H5259-structure
AL3-H5259-sds
ACRO Quality

Part of Bioactivity data

The purity of Human BMPR-1A, His Tag (Cat. No. AL3-H52H9) is more than 90% and the molecular weight of this protein is around 15-25 kDa verified by SEC-MALS.

  • Background
    The bone morphogenetic protein receptor, type IA is also known as BMPR1A or ALK3 is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 290). The bone morphogenetic protein (BMP) re
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Synonym Name

BMPR-1A,ALK-3,ACVRLK3,CD292,SKR5

Background

The bone morphogenetic protein receptor, type IA is also known as BMPR1A or ALK3 is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 290). The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. Alk3-mediated  BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
DWP-431 DWP-431; rhBMP-2 Approved Daewoong Pharmaceutical Co Ltd Novosis, Novosis-Dental South Korea Alveolar Bone Loss Daewoong Pharmaceutical Co Ltd 2013-01-01 Alveolar Bone Loss; Intervertebral Disc Degeneration Details
Dibotermin alfa YM-484; rhBMP-2/CPM Approved Medtronic Inductos EU Tibial Fractures Medtronic Biopharma Bv 2002-09-09 Tibial Fractures; Tooth Injuries; Osteoarthritis, Spine; Fractures, Bone; Osteoarthritis; Radius Fractures Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant Human Bone Morphogenetic Protein-2(University Of Baghdad) Phase 1 Clinical University Of Baghdad Hematologic Diseases; Hypertension; Diabetes Mellitus Details
Recombinant human bone morphogenetic protein 4 (Stemgen) HS-214; hrBMP4 Phase 1 Clinical Stemgen Bronchiolitis Obliterans; Rejection of lung transplantation; Glioblastoma; Lung Diseases; Asthma Details

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