IGFBP-3 R,TMEM219,Insulin-like growth factor-binding protein 3 receptor,Transmembrane protein 219
IGFBP-3 R, also know as TMEM219, is a cell death receptor specific for IGFBP3. IGFBP-3R is expressed on the cell surface, interacts specifically with IGFBP-3 but not other IGFBP species. It activates initiator caspase-8, and mediates IGFBP-3-induced apoptosis in vitro and tumor suppression in vivo.
Clinical and Translational Updates
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