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Your Position: Home > Protein > IGFBP-3 R > IGR-H5259

Human IGFBP-3 R / TMEM219 Protein, Fc Tag (MALS verified)

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  • Synonym
    IGFBP-3 R,TMEM219,Insulin-like growth factor-binding protein 3 receptor,Transmembrane protein 219
  • Source
    Human IGFBP-3 R, Fc Tag(IGR-H5259) is expressed from human 293 cells (HEK293). It contains AA Ser 39 - Arg 204 (Accession # Q86XT9-1).
  • Molecular Characterization
    IGFBP-3 R Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 44.3 kDa. The protein migrates as 58-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
IGFBP-3 R SDS-PAGE

Human IGFBP-3 R, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS
IGFBP-3 R MALS images

The purity of Human IGFBP-3 R, Fc Tag (Cat. No. IGR-H5259) is more than 85% and the molecular weight of this protein is around 100-120 kDa verified by SEC-MALS.

  • Background
    IGFBP-3 R, also know as TMEM219, is a cell death receptor specific for IGFBP3. IGFBP-3R is expressed on the cell surface, interacts specifically with IGFBP-3 but not other IGFBP species. It activates initiator caspase-8, and mediates IGFBP-3-induced apoptosis in vitro and tumor suppression in vivo.
  • Clinical and Translational Updates

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