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Your Position: Home > Complement Factor D

Complement Factor D

Brief Information

Name:Complement factor D
Target Synonym:CFD,Properdin factor D,DF,Complement factor D,D Component Of Complement (Adipsin),PFD,Complement Factor D Preproprotein,Complement Factor D (Adipsin),EC 3.4.21.46,ADN,EC:3.4.21.46,EC 3.4.21 );,EC 3.4.21,C3 Convertase Activator,ADIPSIN
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 3 Clinical

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Synonym Name

CFD,Adipsin,PFD,DF,Complement factor D

Background

Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ACH-5548 ACH-5548; ACH-0145548 Phase 1 Clinical Achillion Pharmaceutical Autoimmune Diseases Details
BCX-9930 BCX-9930 Phase 2 Clinical Biocryst Pharmaceuticals Hemoglobinuria, Paroxysmal Details
ACH-5228 ACH-0145228; ACH-5228; ALXN-2050 Phase 2 Clinical Achillion Pharmaceutical Hemoglobinuria, Paroxysmal; Kidney Diseases Details
Danicopan ACH-4471; ACH-0144471 Phase 3 Clinical Achillion Pharmaceutical Hemoglobinuria, Paroxysmal; Renal Insufficiency; Glomerulonephritis, Membranoproliferative; Hepatic Insufficiency; Glomerulonephritis Details

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