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Complement Factor D

Complement Factor D Molecule Information

Name:Complement Factor D
Target Synonym:Complement factor D;PFD;Properdin factor D;DF ;CFD;C3 convertase activator;Adipsin
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase ?

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Complement Factor D Molecule Synonym Name

CFD,Adipsin,PFD,DF,Complement factor D

Complement Factor D Molecule Background

Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.

Complement Factor D References

Complement Factor D Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Lampalizumab RG-7417; RO-5490249; FCFD-4514S; TNX-234,RG7417,RO5490249 Phase Ⅲ Genentech Age-related macular degeneration (AMD) Details
ACH-5228 ACH-5228; ACH-0145228 Phase Ⅱ Achillion Pharmaceutical Paroxysmal Nocturnal Hemoglobinuria (PNH) Details
ACH-5548 ACH-0145548; ACH-5548 Phase Ⅰ Achillion Pharmaceutical Autoimmune diseases Details
BCX-9930 BCX-9930 Phase Ⅱ BioCryst Paroxysmal Nocturnal Hemoglobinuria (PNH) Details
Danicopan ACH-4471; ACH-0144471 Phase Ⅲ Achillion Pharmaceutical Paroxysmal Nocturnal Hemoglobinuria (PNH) Details

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