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Your Position: Home > Claudin-6

Claudin-6

Brief Information

Name:Claudin 6
Target Synonym:UNQ757/PRO1488,Claudin-6,CLDN6,Claudin 6,Skullin
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
CL6-H52M7 Human Human Claudin-6 / CLDN6 Protein, Flag,His,GFP Tag
CL6-H52M7-structure
CL6-HF2G5 Human Human Claudin-6 / CLDN6 Full Length Protein-VLP (HEK293)

Part of Bioactivity data

CL6-HF2G5-ELISA
 Claudin-6 ELISA

Immobilized Human Claudin-6 Full Length Protein-VLP (Cat. No. CL6-HF2G5) at 5 μg/mL (100 μL/well) can bind Anti-Human Claudin-6 Antibody, Human IgG1 with a linear range of 0.01-0.625 μg/mL (QC tested).

CL6-H52M7-ELISA
 Claudin-6 ELISA

Immobilized Human Claudin-6, Flag,His,GFP Tag (Cat. No. CL6-H52M7) at 5 μg/mL (100 μL/well) can bind Anti-Human Claudin-6 Antibody, Mouse IgG with a linear range of 0.156-2.5 μg/mL (QC tested).

Synonym Name

Claudin-6/CLDN6

Background

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Claudin-6, also knows as CLDN6, is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. And it is one of the entry cofactors for hepatitis C virus. The methylation of CLDN6 may be involved in esophageal tumorigenesis. The gene of CLDN6 is adjacent to another family member CLDN9 on chromosome 16.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SC-004 SC-004 Taisho Pharmaceutical Holdings Co Ltd Details
CLDN6 CAR-T cell therapy (BioNTech) BNT-211 Biontech Se Details
DS-9606a DS-9606a; DS-9606-a Daiichi Sankyo Inc Details
CLDN6-CAR-NK Cell Therapy Phase 2 Clinical Second Affiliated Hospital Of Guangzhou Medical University Ovarian Neoplasms; Testicular Neoplasms Details
IMAB-027 ASP-1650; IMAB-027 Phase 2 Clinical Ganymed Ovarian Neoplasms; Neoplasms; Neoplasms, Germ Cell and Embryonal Details
AMG-794 AMG-794 Phase 1 Clinical Amgen Inc Carcinoma, Ovarian Epithelial; Carcinoma, Non-Small-Cell Lung Details

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