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Your Position: Home > Complement C2

Complement C2

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Cat. No. Species Product Description Structure Purity Feature
CO2-C52H8 Cynomolgus Cynomolgus Complement C2 Protein, His Tag (active enzyme)
CO2-C52H8-structure
CO2-C52H8-sds
CO2-H52H7 Human Human Complement C2 Protein, His Tag (MALS verified) (active enzyme)
CO2-H52H7-structure
CO2-H52H7-sds

Part of Bioactivity data

CO2-H52H7-MALS-HPLC
Human Complement C2, His Tag (Cat. No. ) MALS images

The purity of Human C2, His Tag (Cat. No. CO2-H52H7) is more than 90% and the molecular weight of this protein is around 100-120 kDa verified by SEC-MALS.

Bioactivity

Measured by its ability to cleave a colorimetric peptide substrate, N-carbobenzyloxy-Gly-Arg-ThioBenzyl ester (Z-GR-SBzl), in the presence of 5,5’Dithio-bis (2-nitrobenzoic acid) (DTNB).The specific activity is >100 pmol/min/µg (QC tested).

Synonym Name

C2,Complement C2,Complement Component C2

Background

C2 is a major histocompatibility complex class-III protein. Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. The lectin (LP) and classical (CP) pathways are two of the three main activation cascades of the complement system. These pathways start with recognition of different pathogen- or danger-associated molecular patterns and include identical steps of proteolytic activation of complement component C4, formation of the C3 proconvertase C4b2, followed by cleavage of complement component C2 within C4b2 resulting in the C3 convertase C4b2a.

Clinical and Translational Updates

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