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Your Position: Home > Complement C2

Complement C2

Brief Information

Name:Complement C2
Target Synonym:C3/C5 convertase
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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ACRO Quality

Part of Bioactivity data

Complement C2 MALS images

The purity of Biotinylated Cynomolgus Complement C2 Protein, His,Avitag (Cat. No. CO2-C82E7) is more than 85% and the molecular weight of this protein is around 90-120 kDa verified by SEC-MALS.

Complement C2 MALS images

The purity of Human Complement C2, His Tag (Cat. No. CO2-H52H7) is more than 90% and the molecular weight of this protein is around 90-115 kDa verified by SEC-MALS.

Synonym Name

C2,Complement C2,Complement Component C2


C2 is a major histocompatibility complex class-III protein. Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. The lectin (LP) and classical (CP) pathways are two of the three main activation cascades of the complement system. These pathways start with recognition of different pathogen- or danger-associated molecular patterns and include identical steps of proteolytic activation of complement component C4, formation of the C3 proconvertase C4b2, followed by cleavage of complement component C2 within C4b2 resulting in the C3 convertase C4b2a.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
empasiprubart ARGX-117 Phase 2 Clinical Argenx Se, Broteio Pharma BV Motor Neuron Disease; Peripheral Nervous System Diseases; Dermatomyositis; Myositis; Coronavirus Disease 2019 (COVID-19); Delayed Graft Function Details

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