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C-Reactive Protein

C-Reactive Protein Molecule Information

Name:C-reactive protein
Target Synonym:PTX1;CRP
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
CRP-H5226 Human Human C-Reactive Protein (CRP) Protein, His Tag
CRP-H5226-structure
CRP-H5226-sds

of the pentraxin family of proteins that are characterized by a cyclic pentameric structure. Human CRP gene encodes a 224 amino acids precursor. The mature human CRP protein has 206 amino acids that are noncovalently linked to form the pentameter. Human CRP shares 71% and 64% amino acid sequence homology with mouse and rat respectively. CRP, synthesized by hepatocytes, is a major acute phase serum protein in human. IL6, IL1 and glucocorticoids are the major inducer of the CRP gene. The physiological role of CRP is to bind to phosphocholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system. CRP binds to phosphocholine on microbes and damaged cells and enhances phagocytosis by macrophages. Thus, CRP participates in the clearance of necrotic and apoptotic cells. CRP rises up to 50,000-fold in acute inflammation, such as infection. It rises above normal limits within 6 hours, and peaks at 48 hours. Its half-life is constant, and therefore its level is mainly determined by the rate of production. It has been shown that high levels of CRP in humans is associated with an increased risk of cardiovascular diseases.

C-Reactive Protein References

C-Reactive Protein Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AZ-175 AZ-175; AZ-121 Phase Not Specified University of New Mexico, AZANO biotech Lupus nephritis, Immune thrombocytopenic purpura Details
ISIS-329993 ISIS-329993; ISIS-CRPRx; ISIS-CRP Phase Ⅱ Ionis Atrial fibrillation Details
ISIS-353512 ISIS-353512 Phase Ⅰ Ionis Pharmaceuticals, Korea Institute of Science and Technology Cardiovascular disorders, Kidney disorders, Inflammation, Rheumatoid arthritis (RA), Crohn's disease Details
IB-RA (Innobioscience LLC) IB-RA Phase Ⅱ Innobioscience LLC Rheumatoid arthritis (RA) Details
GLI-8545 GLI-8545,GLI 8545,GLI8545 Phase Not Specified Galileo Pharmaceuticals Renal failure Details

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