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Your Position: Home > M-CSF R

M-CSF R

Brief Information

Name:Colony stimulating factor 1 receptor
Target Synonym:Colony Stimulating Factor 1 Receptor,FIM2,CSF-1R,C-FMS,CSF1R,Proto-Oncogene C-Fms,McDonough Feline Sarcoma Viral (V-Fms) Oncogene Homolog,Macrophage Colony Stimulating Factor I Receptor,Macrophage Colony-Stimulating Factor 1 Receptor,CSFR,FMS Proto-Oncoge
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:20
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CSR-H5255 Human Human M-CSF R / CSF1R / CD115 Protein, Mouse IgG2a Fc Tag (MALS verified)
CSR-H5255-structure
CSR-H5255-sds
CSR-H5255-elisa_1
CSR-R82H5 Rabbit Rabbit M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-R82H5-structure
CSR-R82H5-sds
CSR-C82H3 Canine Canine M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-C82H3-structure
CSR-C82H3-sds
CSR-C82H3-elisa_1
CSR-M82E8 Mouse Biotinylated Mouse M-CSF R / CSF1R / CD115 Protein, Avitag™,His Tag
CSR-M82E8-structure
CSR-M82E8-sds
CSR-M82E8-elisa_1
CSR-H82E0 Human Biotinylated Human M-CSF R / CSF1R / CD115 Protein, Avitag™,His Tag
CSR-H82E0-structure
CSR-H82E0-sds
CSR-H82E0-elisa_1
CSR-C5252 Cynomolgus Cynomolgus M-CSF R / CSF1R / CD115 Protein, Fc Tag
CSR-C5252-structure
CSR-C5252-sds
CSR-C5252-elisa_1
CSR-C52E1 Cynomolgus Cynomolgus M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-C52E1-structure
CSR-C52E1-sds
CSR-C52E1-elisa_1
CSR-M5256 Mouse Mouse M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin
CSR-M5256-structure
CSR-M5256-sds
CSR-M5256-elisa_1
CSR-M52E7 Mouse Mouse M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-M52E7-structure
CSR-M52E7-sds
CSR-M52E7-elisa_1
CSR-H5258 Human Human M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin
CSR-H5258-structure
CSR-H5258-sds
CSR-H5258-elisa_1
CSR-H5258-elisa_2
CSR-H5228 Human Human M-CSF R / CSF1R / CD115 Protein, His Tag (HPLC verified)
CSR-H5228-structure
CSR-H5228-sds
CSR-H5228-hplc
CSR-H5228-elisa_1
CSR-H5228-elisa_2

Part of Bioactivity data

CSR-H5258-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human M-CSF, His Tag (Cat. No. MCF-H5247) captured on CM5 Chip via anti-His antibody can bind Human M-CSF R, Fc Tag, low endotoxin (Cat. No. CSR-H5258) with an affinity constant of 1.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Protocol
CSR-H5228-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) immobilized on SA Chip can bind Human M-CSF R, His Tag (Cat. No. CSR-H5228) with an affinity constant of 0.309 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR

Background

Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR,  FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

Clinical and Translational Updates

Related Molecule

M-CSF

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Mirimostim P-100; CSF-HU Approved Jcr Pharmaceuticals Costilate, Leukoprol Japan Neutropenia Jcr Pharmaceuticals Co Ltd 1991-01-01 Neutropenia Details
Pexidartinib PLX-3397 Approved Daiichi Sankyo Co Ltd Turalio United States Giant Cell Tumor of Tendon Sheath Daiichi Sankyo Inc 2019-08-02 Giant Cell Tumor of Tendon Sheath; Solid tumours; Synovitis, Pigmented Villonodular; Hodgkin Disease; Arthritis, Rheumatoid; Glioblastoma; Giant Cell Tumors; Prostatic Neoplasms; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute Details
Pazopanib Hydrochloride GW-786034; SB-786034; GSK-786034; GW-786034B Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Patorma, Votrient Mainland China Carcinoma, Renal Cell Novartis Pharma Schweiz Ag 2009-10-19 Osteosarcoma; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Melanoma; Carcinoma, Hepatocellular; Fallopian Tube Neoplasms; Glioma; Peritoneal Neoplasms; Colorectal Neoplasms; Prostatic Neoplasms; Ovarian Neoplasms; Breast Neoplasms; Sarcoma; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Hemangiosarcoma; Carcinoma, Renal Cell; Solid tumours; Chondrosarcoma; Telangiectasia, Hereditary Hemorrhagic Details
Regorafenib Monohydrate BAY-73-4506; DAST Approved Bayer Ag Stivarga, Resihance Mainland China Gastrointestinal Stromal Tumors Bayer Pharma Ag 2012-09-27 Solid tumours; Rectal Neoplasms; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Carcinoma, Hepatocellular; Gastrointestinal Neoplasms Details
Surufatinib HMPL-012 Approved Hutchison Medipharma Ltd 苏泰达, SULANDA Mainland China Neuroendocrine Tumors Hutchison Huangpu Medicine (Shanghai) Co Ltd 2020-12-29 Biliary Tract Neoplasms; Pancreatic neuroendocrine tumors (pNET); Neoplasms; Kidney Diseases; Neuroendocrine Tumors; Bile Duct Neoplasms; Hepatic Insufficiency; Thyroid Neoplasms; Carcinoma, Neuroendocrine Details
Sunitinib Malate PHA-290940; SU-010398; SU-11248; GB-102; PNU-290940; SU-011248-L-malate salt; PNU-290940AD; PHA-290940AD Approved Pfizer Pharmaceuticals Ltd (China) Sutent, 索坦 Japan Pancreatic neuroendocrine tumors (pNET) Pfizer Inc 2006-01-26 Diabetic macular oedema; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Retinal Vein Occlusion; Carcinoma, Hepatocellular; Urogenital Neoplasms; Urologic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Prostatic Neoplasms; Breast Neoplasms; Kidney Neoplasms; Neuroendocrine Tumors; Urologic Diseases; Kidney Diseases; Pancreatic neuroendocrine tumors (pNET); Pancreatic Neoplasms; Carcinoma, Islet Cell; Stomach Neoplasms; Carcinoma, Renal Cell; Solid tumours; Liver Neoplasms Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Emactuzumab RG-7155; 6FY6EI1X8R; RO-5509554 Phase 1 Clinical F. Hoffmann-La Roche Ltd Neoplasms; Lymphoma, Non-Hodgkin Details
Q-702 Phase 1 Clinical Qurient Co Ltd Solid tumours; Neoplasm Metastasis Details
Cilmostim CSF-1 Phase 3 Clinical Pfizer Pharmaceuticals Ltd (China) Hypercholesterolemia; Presbyopia Details
TPX-0022 TPX-0022 Phase 1 Clinical Turning Point Therapeutics Neoplasms Details
LY-3022855 IMC-CS4; LY-3022855 Phase 2 Clinical Eli Lilly And Company Neoplasms; Neoplasm Metastasis; Melanoma Details
PMI-04 Phase 1 Clinical Precision Molecular Nerve Degeneration Details
Edicotinib JNJ-244; JNJ-527; PRV-6527; JNJ-40346527 Phase 2 Clinical Johnson & Johnson Arthritis, Rheumatoid; Hodgkin Disease; Leukemia, Myeloid, Acute; Crohn Disease Details
Cabiralizumab FPA-008; ONO-4687; BMS-986227 Phase 2 Clinical Five Prime Therapeutics Giant Cell Tumor of Tendon Sheath; Ovarian Neoplasms; Head and Neck Neoplasms; Lymphoma, T-Cell, Peripheral; Biliary Tract Neoplasms; Synovitis, Pigmented Villonodular; Carcinoma, Renal Cell; Arthritis, Rheumatoid; Pancreatic Neoplasms; Glioma; Melanoma; Carcinoma, Non-Small-Cell Lung Details
NMS-03592088 NMS-P088; NMS-03592088 Phase 2 Clinical Nerviano Medical Sciences Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
PLX-7486 PLX-7486; PLX7486-TsOH Phase 1 Clinical Daiichi Sankyo Co Ltd Giant Cell Tumor of Tendon Sheath; Solid tumours; Pancreatic Neoplasms Details
Axatilimab SNDX-6352; UCB-6352 Phase 2 Clinical Ucb Cytokine Release Syndrome; Solid tumours; Graft vs Host Disease; Respiratory Distress Syndrome, Adult; Coronavirus Infections; Neoplasm Metastasis Details
BLZ-945 BLZ-945 Phase 2 Clinical Novartis Pharma Ag, Celgene Corp Solid tumours; Amyotrophic Lateral Sclerosis Details
ARRY-382 ARRY-382 Phase 2 Clinical Celgene Corp, Array Biopharma Solid tumours; Neoplasm Metastasis Details
DCC-3014 DCC-3014 Phase 2 Clinical Deciphera Giant Cell Tumor of Tendon Sheath; Synovitis, Pigmented Villonodular Details
ABSK-021 ABSK-021 Phase 1 Clinical Abbisko Therapeutics Giant Cell Tumor of Tendon Sheath; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Lung Neoplasms Details
SOMCL-15-290 SOMCL-15-290 Phase 1 Clinical Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Solid tumours; Biliary Tract Neoplasms; Stomach Neoplasms; Carcinoma, Transitional Cell; Breast Neoplasms; Carcinoma, Squamous Cell Details
Vorolanib X-82; EYP-1901; CM-082 Phase 3 Clinical Tyrogenex Solid tumours; Kidney Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Pancreatic neuroendocrine tumors (pNET); Small Cell Lung Carcinoma; Retinal Diseases; Wet Macular Degeneration; Retinal Degeneration; Leukemia, Myeloid, Acute; Thymoma; Macular Degeneration; Melanoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Choroidal Neovascularization Details
C-019199 C019199 Phase 1 Clinical Fujian Haixi New Pharmaceutical Co Ltd Solid tumours Details
BC-006 monoclonal antibody BC-006; BC006 Phase 1 Clinical Dragonboat Biopharmaceutical Giant Cell Tumor of Tendon Sheath; Solid tumours Details
AMB-05X AMB-05X Phase 2 Clinical Amgen Inc Giant Cell Tumor of Tendon Sheath; Synovitis, Pigmented Villonodular; Testicular Neoplasms Details
SYHA-1817 SYHA-1817 Phase 1 Clinical CSPC Pharmaceutical Group Ltd Biliary Tract Neoplasms; Stomach Neoplasms; Carcinoma, Squamous Cell Details
Recombinant human GM-CSF oncolytic herpes simplex virus type 2 (OH2) BS-001; OH-2 Phase 2 Clinical Wuhan Binhui Biotechnology Co Ltd Head and Neck Neoplasms; Carcinoma, Renal Cell; Pancreatic Neoplasms; Digestive System Neoplasms; Central Nervous System Neoplasms; Sarcoma; Breast Neoplasms; Lung Neoplasms; Lymphoma; Melanoma Details

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