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Your Position: Home > M-CSF R

M-CSF R

Brief Information

Name:Colony stimulating factor 1 receptor
Target Synonym:CSFR,CD115 Antigen,FMS Proto-Oncogene,EC 2.7.10.1,CSF1R,Proto-Oncogene C-Fms,Macrophage Colony-Stimulating Factor 1 Receptor,FIM2,McDonough Feline Sarcoma Viral (V-Fms) Oncogene Homolog,CSF-1R,C-FMS,Macrophage Colony Stimulating Factor I Receptor,CD115,HDLS,EC:2.7.10.1,EC 2.7.10,CSF-1-R,CSF-1 Receptor,FMS,BANDDOS,M-CSF-R,Colony Stimulating Factor 1 Receptor
Number of Launched Drugs:8
Number of Drugs in Clinical Trials:37
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CSR-H5543 Human Human M-CSF R Protein, His Tag (active enzyme)
CSR-H5543-structure
CSR-H5543-sds
CSR-H5255 Human Human M-CSF R / CSF1R / CD115 Protein, Mouse IgG2a Fc Tag (MALS verified)
CSR-H5255-structure
CSR-H5255-sds
CSR-R82H5 Rabbit Rabbit M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-R82H5-structure
CSR-R82H5-sds
CSR-C82H3 Canine Canine M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-C82H3-structure
CSR-C82H3-sds
CSR-M82E8 Mouse Biotinylated Mouse M-CSF R / CSF1R / CD115 Protein, Avitag™,His Tag
CSR-M82E8-structure
CSR-M82E8-sds
CSR-H82E0 Human Biotinylated Human M-CSF R / CSF1R / CD115 Protein, Avitag™,His Tag
CSR-H82E0-structure
CSR-H82E0-sds
CSR-C5252 Cynomolgus Cynomolgus M-CSF R / CSF1R / CD115 Protein, Fc Tag
CSR-C5252-structure
CSR-C5252-sds
CSR-C52E1 Cynomolgus Cynomolgus M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-C52E1-structure
CSR-C52E1-sds
CSR-M5256 Mouse Mouse M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin
CSR-M5256-structure
CSR-M5256-sds
CSR-M52E7 Mouse Mouse M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-M52E7-structure
CSR-M52E7-sds
CSR-H5258 Human Human M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin
CSR-H5258-structure
CSR-H5258-sds
CSR-H5228 Human Human M-CSF R / CSF1R / CD115 Protein, His Tag (MALS verified)
CSR-H5228-structure
CSR-H5228-sds
ACRO Quality

Part of Bioactivity data

CSR-H5258-SPR
M-CSF R SPR

Human M-CSF Protein, His Tag (Cat. No. MCF-H5247) captured on CM5 Chip via anti-His antibody can bind Human M-CSF R Protein, Fc Tag (Cat. No. CSR-H5258) with an affinity constant of 1.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Protocol
CSR-H5228-SPR
M-CSF R SPR

Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) immobilized on SA Chip can bind Human M-CSF R, His Tag (Cat. No. CSR-H5228) with an affinity constant of 0.309 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR

Background

Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR,  FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

Clinical and Translational Updates

Related Molecule

M-CSF

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Regorafenib DAST; BAY-73-4506 Approved Bayer AG Stivarga, Resihance United States Colorectal Neoplasms Bayer Healthcare Pharmaceuticals Inc 2012-09-27 Fallopian Tube Neoplasms; Osteosarcoma; Sarcoma, Ewing; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Peritoneal Neoplasms; Bone Neoplasms; Bile Duct Neoplasms; Thymoma; Thyroid Neoplasms; Leukemia, Myeloid, Acute; Gastrinoma; Lung Neoplasms; Esophageal adenocarcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Melanoma; Gastrointestinal Neoplasms; Somatostatinoma; Adenocarcinoma; Neoplasm Metastasis; Meningioma; Neoplasms; Solid tumours; Ovarian Neoplasms; Rectal Neoplasms; Carcinoma, Renal Cell; Hemangiosarcoma; Carcinoid Tumor; Insulinoma; Carcinoma, Islet Cell; Stomach Neoplasms; Esophageal Neoplasms; Liver Neoplasms; Carcinoma, Transitional Cell; Colonic Neoplasms; Pancreatic Neoplasms; Glioblastoma; Carcinoma, Ovarian Epithelial; Adenoma; Glucagonoma; Carcinoma, Adenoid Cystic; Sarcoma Details
Nintedanib Esylate BIBF-1120 Approved C.H. Boehringer Sohn Ag & Co. Kg Ofev, Vargatef United States Idiopathic Pulmonary Fibrosis Boehringer Ingelheim Gmbh 2014-10-15 Lung Neoplasms; Breast Neoplasms; Prostatic Neoplasms; Adenocarcinoma, Clear Cell; systemic sclerosis-associated interstitial lung disease; Colorectal Neoplasms; Peritoneal Neoplasms; Gliosarcoma; Hepatic Insufficiency; Astrocytoma; Genital Neoplasms, Female; Silicosis; Sarcoma; Carcinoma, Squamous Cell; Fallopian Tube Neoplasms; Appendiceal Neoplasms; Leukemia, Myeloid, Acute; Uterine Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Adenocarcinoma; Carcinoma, Endometrioid; Scleroderma, Systemic; Telangiectasia, Hereditary Hemorrhagic; Solid tumours; Rejection of lung transplantation; Carcinoma, Renal Cell; Radiation Pneumonitis; Esophageal Neoplasms; Carcinoid Tumor; Endometrial Stromal Tumors; Idiopathic Pulmonary Fibrosis; Neoplasms; Ovarian Neoplasms; Glioblastoma; Colonic Neoplasms; Small Cell Lung Carcinoma; Pulmonary Fibrosis; Lung Diseases, Interstitial; Oligodendroglioma; Multiple Myeloma; Mesothelioma; Asbestosis; Neuroendocrine Tumors Details
pacritinib citrate SB-1518; ONX-0803 Approved S*BIO Pte Ltd, Concert VONJO United States Primary Myelofibrosis Cti Biopharma Corp 2022-02-28 Hepatic Insufficiency; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Thrombocythemia, Essential; Sarcoma, Kaposi; Thrombocytopenia; Lymphoma, T-Cell; Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Myelomonocytic, Juvenile; Lymphoma, T-Cell, Cutaneous; Leukemia, Myeloid, Acute; Waldenstrom Macroglobulinemia; Colorectal Neoplasms; Lymphoproliferative Disorders; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Lymphoma, T-Cell, Peripheral; Castleman Disease; Primary Myelofibrosis; Coronavirus Infections; Lymphoma, Mantle-Cell; Coronavirus Disease 2019 (COVID-19); Hodgkin Disease; Myeloproliferative Disorders; Leukemia, Myelomonocytic, Chronic; Graft vs Host Disease; Myelodysplastic Syndromes; Polycythemia Vera; Lymphoma, B-Cell; Leukemia, Myelogenous, Chronic; Leukemia Details
Surufatinib HMPL-012 Approved Hutchison Medipharma Ltd 苏泰达, SULANDA Mainland China Neuroendocrine Tumors Hutchison Medipharma Ltd 2020-12-29 Solid tumours; Biliary Tract Neoplasms; Hematologic Neoplasms; Intestinal Neoplasms; Pancreatic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Neoplasms; Kidney Diseases; Small Cell Lung Carcinoma; Neuroendocrine Tumors; Sarcoma; Bile Duct Neoplasms; Hepatic Insufficiency; Thyroid Neoplasms; Appendiceal Neoplasms; Carcinoma, Neuroendocrine Details
Sunitinib Malate PNU-290940AD; PHA-290940AD; SCAI-003; GB-102; PNU-290940; SU-011248-L-malate salt; PHA-290940; SU-010398; SU-11248 Approved Pfizer Inc 索坦, Sutent United States Carcinoma, Renal Cell; Gastrointestinal Stromal Tumors Cppi Cv 2006-01-26 Solid tumours; Fibromatosis, Aggressive; Ovarian Neoplasms; Kidney Neoplasms; Leukemia, Myelogenous, Chronic; Head and Neck Neoplasms; Leiomyosarcoma; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; HIV Infections; Leukemia, Myeloid, Accelerated Phase; Leukemia; Fibrosarcoma; Teratoma; Liver Neoplasms; Ependymoma; Lymphoma, T-Cell, Peripheral; Intestinal Neoplasms; Histiocytoma, Malignant Fibrous; Carcinoma, Renal Cell; Hemangioblastoma; Carcinoma, Islet Cell; Carcinoma; Pheochromocytoma; Stomach Neoplasms; Pelvic Neoplasms; Esophageal Neoplasms; Leukemia, Hairy Cell; Polycythemia Vera; Abdominal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Thoracic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Carcinoma, Ovarian Epithelial; Glioblastoma; Neurofibromatoses; Small Cell Lung Carcinoma; Adenoma, Islet Cell; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Lymphoma, Large B-Cell, Diffuse; Neoplasms; Myelodysplastic Syndromes; Hodgkin Disease; Leukemia, Myelomonocytic, Chronic; Carcinoma, Papil Details
Pexidartinib PLX-3397 Approved Daiichi Sankyo Co Ltd Turalio United States Giant Cell Tumor of Tendon Sheath Daiichi Sankyo Inc 2019-08-02 Prostatic Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma; Neoplasm Metastasis; Leukemia, Myeloid, Acute; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Neurofibrosarcoma; Giant Cell Tumors; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Neurofibroma, Plexiform; Sarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours; Breast Neoplasms; Neoplasms; Arthritis, Rheumatoid; Hodgkin Disease; Glioblastoma; Pancreatic Neoplasms; Synovitis, Pigmented Villonodular; Squamous Cell Carcinoma of Head and Neck; Leukemia, Promyelocytic, Acute; Ovarian Neoplasms; Giant Cell Tumor of Tendon Sheath Details
Mirimostim P-100; CSF-HU Approved Jcr Pharmaceuticals Co Ltd Costilate, Leukoprol Japan Neutropenia Jcr Pharmaceuticals Co Ltd 1991-01-01 Neutropenia Details
Pazopanib Hydrochloride GSK-786034; GW-786034B; SB-786034; GW-786034 Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Votrient, Patorma United States Carcinoma, Renal Cell; Sarcoma Novartis Pharma Ag 2009-10-19 Uterine Cervical Diseases; Fallopian Tube Neoplasms; Lung Neoplasms; Uterine Neoplasms; Choriocarcinoma; Lymphoma; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Carcinoma, Mucoepidermoid; Gliosarcoma; Genital Neoplasms, Female; Leukemia, Myeloid, Acute; Peritoneal Neoplasms; Brain Neoplasms; Urethral Neoplasms; Medullary thyroid cancer (MTC); Chondrosarcoma, Extraskeletal Myxoid; Prostatic Neoplasms; Osteosarcoma; Neuroblastoma; Sarcoma; Breast Neoplasms; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms; Breast Neoplasms, Male; Neoplasm Metastasis; von Hippel-Lindau Disease; Thyroid Cancer, Papillary; Gastrointestinal Neoplasms; Paraganglioma; Endodermal Sinus Tumor; Neoplasms, Germ Cell and Embryonal; Melanoma; Gastrinoma; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Small Cell; Carcinoma, Embryonal; Germinoma; Glioma; Carcinoma, Neuroendocrine; Epistaxis; Carcinoma, Ovarian Epithelial; Neoplasms; Squamous Cell Carcinoma of Head a Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Vimseltinib DCC-3014 Phase 3 Clinical Deciphera Giant Cell Tumor of Tendon Sheath; Synovitis, Pigmented Villonodular; Neoplasms Details
Chiauranib CS-2164; CS2164 Phase 3 Clinical Shenzhen Chipscreen Biosciences Co Ltd Solid tumours; Ovarian Neoplasms; Neoplasms; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Sarcoma; Lymphoma, Non-Hodgkin; Carcinoma, Hepatocellular Details
Pimicotinib ABSK-021 Phase 3 Clinical ABbisko Therapeutics Co Ltd Giant Cell Tumor of Tendon Sheath; Solid tumours; Synovitis, Pigmented Villonodular; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Neoplasms; Graft vs Host Disease; Sarcoma; Lung Neoplasms; Amyotrophic Lateral Sclerosis Details
Emactuzumab RG-7155; 6FY6EI1X8R; RO-5509554 Phase 3 Clinical F. Hoffmann-La Roche Ltd Solid tumours; Head and Neck Neoplasms; Carcinoma; Neoplasms; Prostatic Neoplasms; Testicular Neoplasms; Lymphoma, Non-Hodgkin; Carcinoma, Squamous Cell Details
Recombinant human GM-CSF oncolytic herpes simplex virus type 2 (OH2) BS-001; BS001; oHSV-2; OH-2; OH2 Phase 3 Clinical Wuhan Binhui Biotechnology Co Ltd Central Nervous System Neoplasms; Melanoma; Lymphoma; Lung Neoplasms; Colorectal Neoplasms; Bile Duct Neoplasms; Breast Neoplasms; Sarcoma; Liver Diseases; Solid tumours; Digestive System Neoplasms; Urinary Bladder Neoplasms; Neoplasms; Pancreatic Neoplasms; Esophageal Neoplasms; Liver Neoplasms; Head and Neck Neoplasms Details
Tinengotinib TT-00420; TT 00420; TT00420 Phase 3 Clinical TransThera Sciences (Nanjing) Inc Biliary Tract Neoplasms; Solid tumours; Kidney Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Transitional Cell; Urinary Bladder Neoplasms; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms; Breast Neoplasms; Cholangiocarcinoma; Sarcoma; Thyroid Neoplasms; Gallbladder Neoplasms Details
LY-3022855 IMC-CS4; LY-3022855 Phase 2 Clinical Eli Lilly And Company Solid tumours; Pancreatic Neoplasms; Neoplasms; Neoplasm Metastasis; Melanoma Details
Simmitinib hydrochloride SOMCL-15-290 Phase 2 Clinical Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Solid tumours; Neoplasms; Esophageal Squamous Cell Carcinoma Details
NMS-03592088 NMS-P088; NMS-03592088 Phase 2 Clinical Nerviano Medical Sciences Srl Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
Cabiralizumab FPA-008; ONO-4687; BMS-986227 Phase 2 Clinical Five Prime Therapeutics Inc Solid tumours; Head and Neck Neoplasms; Ovarian Neoplasms; Giant Cell Tumor of Tendon Sheath; Lymphoma, T-Cell, Peripheral; Carcinoma, Renal Cell; Synovitis, Pigmented Villonodular; Triple Negative Breast Neoplasms; Neoplasms; Pancreatic Neoplasms; Arthritis, Rheumatoid; Glioma; Carcinoma, Non-Small-Cell Lung Details
AMG-820 AMG-820 Phase 2 Clinical Amgen Inc Solid tumours; Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Derazantinib ARQ-087.2HCl; AQ-14741087; ARQ-087; BAL-087 Phase 2 Clinical Arqule Inc Biliary Tract Neoplasms; Solid tumours; Stomach Neoplasms; Carcinoma, Transitional Cell; Cholangiocarcinoma; Urogenital Neoplasms; Carcinoma, Hepatocellular Details
HH185 3D-185; 3-D185; HH-185; 3D185 Phase 2 Clinical ShangHai HaiHe Biopharma Co Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, Shanghai Medicilon Inc Solid tumours; Cholangiocarcinoma Details
C-019199 C019199 Phase 2 Clinical Fujian Haixi Pharmaceuticals Co Ltd Solid tumours Details
Edicotinib PRV-6527; JNJ-244; JNJ-40346527-AAC-G-002; JNJ-40346527; JNJ-527 Phase 2 Clinical Johnson & Johnson Arthritis, Rheumatoid; Hodgkin Disease; Prostatic Neoplasms; Alzheimer Disease; Cognitive Dysfunction; Leukemia, Myeloid, Acute; Crohn Disease Details
Sotuletinib BLZ-945 Phase 2 Clinical Novartis Pharma Ag, Celgene Corp Solid tumours; Amyotrophic Lateral Sclerosis Details
Elzovantinib TPX-0022 Phase 2 Clinical Turning Point Therapeutics Inc Solid tumours; Stomach Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
[11C]CPPC Phase 2 Clinical Johns Hopkins University Post-Acute COVID-19 Syndrome; Amyotrophic Lateral Sclerosis Details
AMB-05X AMB-05X Phase 2 Clinical Amgen Inc Giant Cell Tumor of Tendon Sheath; Synovitis, Pigmented Villonodular; Idiopathic Pulmonary Fibrosis; Testicular Neoplasms Details
Q-702 Q-702 Phase 2 Clinical Vichem Chemie, Max Planck Institute of Biochemistry, Lead Discovery Center GmbH Solid tumours; Liver Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Neoplasms; Neoplasm Metastasis; Uterine Cervical Neoplasms Details
PMI-04 Phase 1 Clinical Precision Molecular Inc Nerve Degeneration Details
APL-102 APL-102; CBT-102 Phase 1 Clinical Apollomics Inc Solid tumours Details
Pamufetinib TAS-115 Phase 1 Clinical Taiho Pharmaceutical Co Ltd, Otsuka Pharmaceutical Co Ltd Neoplasms Details
JDB-383 JDB-383 Phase 1 Clinical Shanghai Jiabao Yaoyin Pharmaceutical Technology Co Ltd Giant Cell Tumor of Tendon Sheath Details
HMPL-653 HMPL-653 Phase 1 Clinical Hutchison Medipharma Ltd Giant Cell Tumor of Tendon Sheath; Solid tumours; Testicular Neoplasms Details
ETH-155036 ETH-155036; ETH155036 Phase 1 Clinical Shengke Pharmaceutical (Jiangsu) Co Ltd Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
Caflanone FBL-03G Phase 1 Clinical Flavocure Biotech Inc Pancreatic Neoplasms Details
Nintedanib Solution for Inhalation AP02; AP-02 Phase 1 Clinical Avalyn Pharma Inc Idiopathic Pulmonary Fibrosis Details
EI-1071 EI-1071; FB-1071 Phase 1 Clinical Elixiron Immunotherapeutics Inc Giant Cell Tumor of Tendon Sheath; Alzheimer Disease; Nervous System Diseases; Amyotrophic Lateral Sclerosis Details
SYHA-1817 SYHA-1817 Phase 1 Clinical CSPC Pharmaceutical Group Ltd Biliary Tract Neoplasms; Stomach Neoplasms; Carcinoma, Squamous Cell Details
TT-00420/Atezolizumab Phase 1 Clinical TransThera Sciences (Nanjing) Inc Gastrointestinal Neoplasms Details
BC-006 BC-006; BC006 Phase 1 Clinical Dragonboat Biopharmaceutical Solid tumours; Giant Cell Tumor of Tendon Sheath Details
AGX-0073 AGX-0073 Phase 1 Clinical Shanghai Aojian Biological Technology Co Ltd Solid tumours Details
SYHA-1813 SYHA1813 Phase 1 Clinical Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, Shanghai Runshi Pharmaceutical Technology Co Ltd Giant Cell Tumor of Tendon Sheath; Solid tumours; Carcinoma, Renal Cell; Stomach Neoplasms; Gliosarcoma; Colorectal Neoplasms; Brain metastases; Thyroid Neoplasms; Lung Neoplasms; Glioma Details

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