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Your Position: Home > M-CSF R

M-CSF R

Brief Information

Name:Colony stimulating factor 1 receptor
Target Synonym:CSFR,CD115 Antigen,FMS Proto-Oncogene,EC 2.7.10.1,CSF1R,Proto-Oncogene C-Fms,Macrophage Colony-Stimulating Factor 1 Receptor,FIM2,McDonough Feline Sarcoma Viral (V-Fms) Oncogene Homolog,CSF-1R,C-FMS,Macrophage Colony Stimulating Factor I Receptor,CD115,HDLS,EC:2.7.10.1,EC 2.7.10,CSF-1-R,CSF-1 Receptor,FMS,BANDDOS,M-CSF-R,Colony Stimulating Factor 1 Receptor
Number of Launched Drugs:6
Number of Drugs in Clinical Trials:23
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CSR-H5255 Human Human M-CSF R / CSF1R / CD115 Protein, Mouse IgG2a Fc Tag (MALS verified)
CSR-H5255-structure
CSR-H5255-sds
CSR-H5255-elisa_1
CSR-R82H5 Rabbit Rabbit M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-R82H5-structure
CSR-R82H5-sds
CSR-C82H3 Canine Canine M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-C82H3-structure
CSR-C82H3-sds
CSR-C82H3-elisa_1
CSR-M82E8 Mouse Biotinylated Mouse M-CSF R / CSF1R / CD115 Protein, Avitag™,His Tag
CSR-M82E8-structure
CSR-M82E8-sds
CSR-M82E8-elisa_1
CSR-H82E0 Human Biotinylated Human M-CSF R / CSF1R / CD115 Protein, Avitag™,His Tag
CSR-H82E0-structure
CSR-H82E0-sds
CSR-H82E0-elisa_1
CSR-C5252 Cynomolgus Cynomolgus M-CSF R / CSF1R / CD115 Protein, Fc Tag
CSR-C5252-structure
CSR-C5252-sds
CSR-C5252-elisa_1
CSR-C52E1 Cynomolgus Cynomolgus M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-C52E1-structure
CSR-C52E1-sds
CSR-C52E1-elisa_1
CSR-M5256 Mouse Mouse M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin
CSR-M5256-structure
CSR-M5256-sds
CSR-M5256-elisa_1
CSR-M52E7 Mouse Mouse M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-M52E7-structure
CSR-M52E7-sds
CSR-M52E7-elisa_1
CSR-H5258 Human Human M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin
CSR-H5258-structure
CSR-H5258-sds
CSR-H5258-elisa_1
CSR-H5258-elisa_2
CSR-H5228 Human Human M-CSF R / CSF1R / CD115 Protein, His Tag (HPLC verified)
CSR-H5228-structure
CSR-H5228-sds
CSR-H5228-hplc
CSR-H5228-elisa_1
CSR-H5228-elisa_2

Part of Bioactivity data

CSR-H5258-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human M-CSF, His Tag (Cat. No. MCF-H5247) captured on CM5 Chip via anti-His antibody can bind Human M-CSF R, Fc Tag, low endotoxin (Cat. No. CSR-H5258) with an affinity constant of 1.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Protocol
CSR-H5228-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) immobilized on SA Chip can bind Human M-CSF R, His Tag (Cat. No. CSR-H5228) with an affinity constant of 0.309 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR

Background

Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR,  FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

Clinical and Translational Updates

Related Molecule

M-CSF

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Mirimostim P-100; CSF-HU Approved Jcr Pharmaceuticals Costilate, Leukoprol Japan Neutropenia Jcr Pharmaceuticals Co Ltd 1991-01-01 Neutropenia Details
Surufatinib HMPL-012 Approved Hutchison Medipharma Ltd 苏泰达, SULANDA Mainland China Neuroendocrine Tumors Hutchison Huangpu Medicine (Shanghai) Co Ltd 2020-12-29 Solid tumours; Hematologic Neoplasms; Biliary Tract Neoplasms; Kidney Diseases; Pancreatic neuroendocrine tumors (pNET); Neuroendocrine Tumors; Bile Duct Neoplasms; Hepatic Insufficiency; Thyroid Neoplasms; Carcinoma, Neuroendocrine Details
Pexidartinib PLX-3397 Approved Daiichi Sankyo Co Ltd Turalio United States Giant Cell Tumor of Tendon Sheath Daiichi Sankyo Inc 2019-08-02 Giant Cell Tumor of Tendon Sheath; Solid tumours; Synovitis, Pigmented Villonodular; Hodgkin Disease; Arthritis, Rheumatoid; Glioblastoma; Giant Cell Tumors; Prostatic Neoplasms; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute Details
Pazopanib Hydrochloride GW-786034; SB-786034; GSK-786034; GW-786034B Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Patorma, Votrient Mainland China Carcinoma, Renal Cell Novartis Pharma Schweiz Ag 2009-10-19 Osteosarcoma; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Melanoma; Carcinoma, Hepatocellular; Fallopian Tube Neoplasms; Glioma; Peritoneal Neoplasms; Colorectal Neoplasms; Prostatic Neoplasms; Ovarian Neoplasms; Breast Neoplasms; Sarcoma; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Hemangiosarcoma; Carcinoma, Renal Cell; Solid tumours; Chondrosarcoma; Telangiectasia, Hereditary Hemorrhagic Details
Regorafenib DAST; BAY-73-4506 Approved Bayer Ag Resihance, Stivarga Mainland China Gastrointestinal Stromal Tumors Bayer Pharma Ag 2012-09-27 Solid tumours; Carcinoma, Renal Cell; Rectal Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Carcinoma, Hepatocellular; Gastrointestinal Neoplasms Details
Sunitinib Malate PHA-290940; SU-010398; SU-11248; GB-102; PNU-290940; SU-011248-L-malate salt; PNU-290940AD; PHA-290940AD Approved Pfizer Pharmaceuticals Ltd (China) Sutent, 索坦 Japan Pancreatic neuroendocrine tumors (pNET) Pfizer Inc 2006-01-26 Breast Neoplasms; Retinal Vein Occlusion; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Macular Degeneration; Carcinoma, Hepatocellular; Urogenital Neoplasms; Urologic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Diabetic macular oedema; Prostatic Neoplasms; Kidney Neoplasms; Neuroendocrine Tumors; Urologic Diseases; Kidney Diseases; Pancreatic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Stomach Neoplasms; Carcinoma, Islet Cell; Carcinoma, Renal Cell; Liver Neoplasms; Solid tumours Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Edicotinib JNJ-244; JNJ-527; PRV-6527; JNJ-40346527 Phase 2 Clinical Johnson & Johnson Arthritis, Rheumatoid; Hodgkin Disease; Leukemia, Myeloid, Acute; Crohn Disease Details
C-019199 C019199 Phase 1 Clinical Fujian Haixi New Pharmaceutical Co Ltd Solid tumours Details
Emactuzumab RG-7155; 6FY6EI1X8R; RO-5509554 Phase 1 Clinical F. Hoffmann-La Roche Ltd Solid tumours; Lymphoma, Non-Hodgkin Details
SOMCL-15-290 SOMCL-15-290 Phase 1 Clinical Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Solid tumours; Biliary Tract Neoplasms; Stomach Neoplasms; Carcinoma, Transitional Cell; Breast Neoplasms; Carcinoma, Squamous Cell Details
AMB-05X AMB-05X Phase 2 Clinical Amgen Inc Giant Cell Tumor of Tendon Sheath; Synovitis, Pigmented Villonodular; Testicular Neoplasms Details
BLZ-945 BLZ-945 Phase 2 Clinical Novartis Pharma Ag, Celgene Corp Solid tumours; Amyotrophic Lateral Sclerosis Details
Cilmostim CSF-1 Phase 3 Clinical Pfizer Pharmaceuticals Ltd (China) Hypercholesterolemia; Presbyopia Details
Vimseltinib DCC-3014 Phase 3 Clinical Deciphera Giant Cell Tumor of Tendon Sheath; Synovitis, Pigmented Villonodular Details
LY-3022855 IMC-CS4; LY-3022855 Phase 2 Clinical Eli Lilly And Company Solid tumours; Neoplasm Metastasis; Melanoma Details
PMI-04 Phase 1 Clinical Precision Molecular Nerve Degeneration Details
BC-006 monoclonal antibody BC-006; BC006 Phase 1 Clinical Dragonboat Biopharmaceutical Giant Cell Tumor of Tendon Sheath; Solid tumours Details
SYHA-1817 SYHA-1817 Phase 1 Clinical CSPC Pharmaceutical Group Ltd Biliary Tract Neoplasms; Stomach Neoplasms; Carcinoma, Squamous Cell Details
Cabiralizumab FPA-008; ONO-4687; BMS-986227 Phase 2 Clinical Five Prime Therapeutics Giant Cell Tumor of Tendon Sheath; Lymphoma, T-Cell, Peripheral; Biliary Tract Neoplasms; Ovarian Neoplasms; Head and Neck Neoplasms; Solid tumours; Synovitis, Pigmented Villonodular; Carcinoma, Renal Cell; Arthritis, Rheumatoid; Pancreatic Neoplasms; Glioma; Melanoma; Carcinoma, Non-Small-Cell Lung Details
TT-00420 TT-00420 Phase 2 Clinical Yaojie Ankang (Nanjing) Technology Co Ltd Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Sarcoma; Cholangiocarcinoma; Breast Neoplasms; Prostatic Neoplasms; Gallbladder Neoplasms; Thyroid Neoplasms Details
Derazantinib ARQ-087; BAL-087; ARQ-087.2HCl; AQ-14741087 Phase 2 Clinical Arqule Solid tumours; Biliary Tract Neoplasms; Stomach Neoplasms; Carcinoma, Transitional Cell; Cholangiocarcinoma; Urogenital Neoplasms; Carcinoma, Hepatocellular Details
Elzovantinib TPX-0022 Phase 1 Clinical Turning Point Therapeutics Inc Solid tumours Details
EI-1071 EI-1071 Phase 1 Clinical Elixiron Immunotherapeutics Inc Giant Cell Tumor of Tendon Sheath; Alzheimer Disease Details
TT-00420/Atezolizumab Phase 1 Clinical Yaojie Ankang (Nanjing) Technology Co Ltd Gastrointestinal Neoplasms Details
NMS-03592088 NMS-P088; NMS-03592088 Phase 2 Clinical Nerviano Medical Sciences Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
ABSK-021 ABSK-021 Phase 1 Clinical Abbisko Therapeutics Solid tumours; Giant Cell Tumor of Tendon Sheath; Pancreatic Neoplasms; Graft vs Host Disease; Triple Negative Breast Neoplasms; Sarcoma; Lung Neoplasms; Amyotrophic Lateral Sclerosis Details
Q-702 Q-702 Phase 1 Clinical Qurient Co Ltd Solid tumours; Neoplasm Metastasis Details
HMPL-653 HMPL-653 Phase 1 Clinical Hutchison Huangpu Medicine (Shanghai) Co Ltd Solid tumours; Giant Cell Tumor of Tendon Sheath Details
Axatilimab SNDX-6352; UCB-6352 Phase 2 Clinical Ucb, Incyte Corp Cytokine Release Syndrome; Solid tumours; Graft vs Host Disease; Respiratory Distress Syndrome, Adult; Coronavirus Infections; Neoplasm Metastasis Details
APL-102 APL-102; CBT-102 Phase 1 Clinical Apollomics Solid tumours Details
Recombinant human GM-CSF oncolytic herpes simplex virus type 2 (OH2) BS-001; OH-2 Phase 2 Clinical Wuhan Binhui Biotechnology Co Ltd Solid tumours; Head and Neck Neoplasms; Carcinoma, Renal Cell; Esophageal Neoplasms; Pancreatic Neoplasms; Central Nervous System Neoplasms; Urinary Bladder Neoplasms; Digestive System Neoplasms; Breast Neoplasms; Sarcoma; Colorectal Neoplasms; Lymphoma; Lung Neoplasms; Melanoma Details

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