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Your Position: Home > M-CSF R

M-CSF R

Brief Information

Name:Colony stimulating factor 1 receptor
Target Synonym:CSFR,CD115 Antigen,FMS Proto-Oncogene,EC 2.7.10.1,CSF1R,Proto-Oncogene C-Fms,Macrophage Colony-Stimulating Factor 1 Receptor,FIM2,McDonough Feline Sarcoma Viral (V-Fms) Oncogene Homolog,CSF-1R,C-FMS,Macrophage Colony Stimulating Factor I Receptor,CD115,HDLS,EC:2.7.10.1,EC 2.7.10,CSF-1-R,CSF-1 Receptor,FMS,BANDDOS,M-CSF-R,Colony Stimulating Factor 1 Receptor
Number of Launched Drugs:6
Number of Drugs in Clinical Trials:23
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CSR-H5255 Human Human M-CSF R / CSF1R / CD115 Protein, Mouse IgG2a Fc Tag (MALS verified)
CSR-H5255-structure
CSR-H5255-sds
CSR-R82H5 Rabbit Rabbit M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-R82H5-structure
CSR-R82H5-sds
CSR-C82H3 Canine Canine M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-C82H3-structure
CSR-C82H3-sds
CSR-M82E8 Mouse Biotinylated Mouse M-CSF R / CSF1R / CD115 Protein, Avitag™,His Tag
CSR-M82E8-structure
CSR-M82E8-sds
CSR-H82E0 Human Biotinylated Human M-CSF R / CSF1R / CD115 Protein, Avitag™,His Tag
CSR-H82E0-structure
CSR-H82E0-sds
CSR-C5252 Cynomolgus Cynomolgus M-CSF R / CSF1R / CD115 Protein, Fc Tag
CSR-C5252-structure
CSR-C5252-sds
CSR-C52E1 Cynomolgus Cynomolgus M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-C52E1-structure
CSR-C52E1-sds
CSR-M5256 Mouse Mouse M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin
CSR-M5256-structure
CSR-M5256-sds
CSR-M52E7 Mouse Mouse M-CSF R / CSF1R / CD115 Protein, His Tag
CSR-M52E7-structure
CSR-M52E7-sds
CSR-H5258 Human Human M-CSF R / CSF1R / CD115 Protein, Fc Tag, low endotoxin
CSR-H5258-structure
CSR-H5258-sds
CSR-H5228 Human Human M-CSF R / CSF1R / CD115 Protein, His Tag (HPLC verified)
CSR-H5228-structure
CSR-H5228-sds
CSR-H5228-hplc

Part of Bioactivity data

CSR-H5258-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human M-CSF, His Tag (Cat. No. MCF-H5247) captured on CM5 Chip via anti-His antibody can bind Human M-CSF R, Fc Tag, low endotoxin (Cat. No. CSR-H5258) with an affinity constant of 1.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Protocol
CSR-H5228-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) immobilized on SA Chip can bind Human M-CSF R, His Tag (Cat. No. CSR-H5228) with an affinity constant of 0.309 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR

Background

Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR,  FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

Clinical and Translational Updates

Related Molecule

M-CSF

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Mirimostim P-100; CSF-HU Approved Jcr Pharmaceuticals Costilate, Leukoprol Japan Neutropenia Jcr Pharmaceuticals Co Ltd 1991-01-01 Neutropenia Details
Pazopanib Hydrochloride GSK-786034; GW-786034B; SB-786034; GW-786034 Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Votrient, Patorma Mainland China Carcinoma, Renal Cell Novartis Pharma Schweiz Ag 2009-10-19 Urogenital Neoplasms; Prostatic Neoplasms; Osteosarcoma; Peritoneal Neoplasms; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Carcinoma, Small Cell; Leukemia, Myeloid, Acute; Sarcoma, Alveolar Soft Part; Fallopian Tube Neoplasms; Thyroid Neoplasms; Lung Neoplasms; Breast Neoplasms; Glioma; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms; Uterine Cervical Neoplasms; Macular Degeneration; Melanoma; Neoplasm Metastasis; Carcinoma, Hepatocellular; Thyroid Cancer, Papillary; Neoplasms, Germ Cell and Embryonal; Neoplasms; Ovarian Neoplasms; Solid tumours; Chondrosarcoma; Epistaxis; Telangiectasia, Hereditary Hemorrhagic; Leiomyosarcoma; Carcinoma, Renal Cell; Hemangiosarcoma; Squamous Cell Carcinoma of Head and Neck; Thoracic Neoplasms; Head and Neck Neoplasms; Small Cell Lung Carcinoma; Glioblastoma; Pancreatic Neoplasms; Dermatofibrosarcoma; Central Nervous System Neoplasms; Lymphedema; Liposarcoma; Adenocarcinoma, Follicular; Soft Tissue Neoplasms; Sarcoma Details
Pexidartinib PLX-3397 Approved Daiichi Sankyo Co Ltd Turalio United States Giant Cell Tumor of Tendon Sheath Daiichi Sankyo Inc 2019-08-02 Giant Cell Tumor of Tendon Sheath; Solid tumours; Synovitis, Pigmented Villonodular; Hodgkin Disease; Glioblastoma; Neoplasms; Giant Cell Tumors; Prostatic Neoplasms; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute; Melanoma Details
Regorafenib DAST; BAY-73-4506 Approved Bayer AG Stivarga, Resihance Mainland China Gastrointestinal Stromal Tumors Bayer Pharma Ag 2012-09-27 Leukemia, Myeloid, Acute; Sarcoma; Gastrinoma; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Bile Duct Neoplasms; Peritoneal Neoplasms; Lymphoma, Non-Hodgkin; Lung Neoplasms; Carcinoma, Adenoid Cystic; Thyroid Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Hepatocellular; Melanoma; Neoplasm Metastasis; Gastrointestinal Neoplasms; Somatostatinoma; Solid tumours; Glucagonoma; Multiple Myeloma; Pancreatic Neoplasms; Carcinoma, Ovarian Epithelial; Carcinoma, Transitional Cell; Neoplasms; Glioblastoma; Colonic Neoplasms; Hemangiosarcoma; Carcinoma, Islet Cell; Insulinoma; Carcinoid Tumor; Rectal Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms Details
Nintedanib Esylate BIBF-1120 Approved C.H. Boehringer Sohn Ag & Co. Kg Ofev, Vargatef EU systemic sclerosis-associated interstitial lung disease Boehringer Ingelheim International Gmbh 2014-10-15 Genital Neoplasms, Female; Sarcoma; Prostatic Neoplasms; systemic sclerosis-associated interstitial lung disease; Breast Neoplasms; Adenocarcinoma, Clear Cell; Peritoneal Neoplasms; Colorectal Neoplasms; Astrocytoma; Hepatic Insufficiency; Oligodendroglioma; Bronchitis; Silicosis; Gliosarcoma; Appendiceal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Idiopathic Pulmonary Fibrosis; Head and Neck Neoplasms; Telangiectasia, Hereditary Hemorrhagic; Bronchiolitis Obliterans; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Rejection of lung transplantation; Carcinoma, Renal Cell; Scleroderma, Systemic; Ovarian Neoplasms; Neoplasms; Carcinoma, Transitional Cell; Glioblastoma; Small Cell Lung Carcinoma; Pulmonary Fibrosis; Lung Diseases, Interstitial; Multiple Myeloma; Asbestosis Details
Surufatinib HMPL-012 Approved Hutchison Medipharma Ltd 苏泰达, SULANDA Mainland China Neuroendocrine Tumors Hutchison Huangpu Medicine (Shanghai) Co Ltd 2020-12-29 Neuroendocrine Tumors; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Appendiceal Neoplasms; Thyroid Neoplasms; Colorectal Neoplasms; Bile Duct Neoplasms; Hepatic Insufficiency; Nasopharyngeal Carcinoma; Sarcoma; Solid tumours; Pancreatic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Kidney Diseases; Neoplasms; Small Cell Lung Carcinoma; Hematologic Neoplasms; Intestinal Neoplasms; Head and Neck Neoplasms; Biliary Tract Neoplasms Details
Pacritinib SB-1518; ONX-0803 Approved Syncore Biotechnology Co Ltd, Concert VONJO United States Primary Myelofibrosis Cti Biopharma Corp 2022-02-28 Breast Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Thrombocythemia, Essential; Lymphoma, T-Cell; Waldenstrom Macroglobulinemia; Thrombocytopenia; Lymphoma, T-Cell, Cutaneous; Lymphoma, Non-Hodgkin; Lymphoma; Leukemia, Myeloid, Acute; Lymphoproliferative Disorders; Colorectal Neoplasms; Primary Myelofibrosis; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Coronavirus Infections; Lymphoma, Mantle-Cell; Coronavirus Disease 2019 (COVID-19); Leukemia, Myelomonocytic, Chronic; Hodgkin Disease; Myeloproliferative Disorders; Myelodysplastic Syndromes; Polycythemia Vera; Lymphoma, T-Cell, Peripheral; Leukemia; Lymphoma, B-Cell Details
Sunitinib Malate PHA-290940; SU-010398; SU-11248; PNU-290940AD; PHA-290940AD; GB-102; PNU-290940; SU-011248-L-malate salt Approved Pfizer Pharmaceuticals Ltd (China) 索坦, Sutent Japan Pancreatic neuroendocrine tumors (pNET) Pfizer Inc 2006-01-26 Diabetic macular oedema; Thyroid Neoplasms; Lung Neoplasms; Lymphoma, Non-Hodgkin; Peritoneal Neoplasms; Astrocytoma; Thymus Neoplasms; Urologic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Thymoma; Neurofibroma, Plexiform; Cholangiocarcinoma; Medullary thyroid cancer (MTC); Brain Neoplasms; Urethral Neoplasms; Prostatic Neoplasms; Sarcoma; Breast Neoplasms; Adrenocortical Carcinoma; Adenocarcinoma; Paraganglioma; Melanoma; Thyroid Cancer, Papillary; Retinal Vein Occlusion; Meningioma; von Hippel-Lindau Disease; Neoplasm Metastasis; Macular Degeneration; Carcinoma, Hepatocellular; Adenocarcinoma, Follicular; Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Neoplasms, Gonadal Tissue; Nervous System Neoplasms; Germinoma; Brain metastases; Hemangiopericytoma; Urogenital Neoplasms; Hemangioblastoma; Glioblastoma; Pheochromocytoma; Pelvic Neoplasms; Thoracic Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Carcinoma, Islet Cell; Histiocytom Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
TT-00420/Atezolizumab Phase 1 Clinical Gastrointestinal Neoplasms Details
C-019199 C019199 Phase 1 Clinical Fujian Haixi New Pharmaceutical Co Ltd Solid tumours Details
PMI-04 Phase 1 Clinical Nerve Degeneration Details
AGX-0073 AGX-0073 Phase 1 Clinical Shanghai Aojian Biological Technology Co Ltd Solid tumours Details
JDB-383 JDB-383 Phase 1 Clinical Shanghai Jiabao Yaoyin Pharmaceutical Technology Co Ltd Giant Cell Tumor of Tendon Sheath Details
SYHA-1817 SYHA-1817 Phase 1 Clinical CSPC Pharmaceutical Group Ltd Biliary Tract Neoplasms; Stomach Neoplasms; Carcinoma, Squamous Cell Details
BC-006 BC-006; BC006 Phase 1 Clinical Dragonboat Biopharmaceutical Giant Cell Tumor of Tendon Sheath; Solid tumours Details
EI-1071 EI-1071 Phase 1 Clinical Elixiron Immunotherapeutics Inc Giant Cell Tumor of Tendon Sheath; Alzheimer Disease Details
Elzovantinib TPX-0022 Phase 2 Clinical Turning Point Therapeutics Inc Solid tumours; Stomach Neoplasms; Carcinoma, Non-Small-Cell Lung Details
BLZ-945 BLZ-945 Novartis Pharma Ag, Celgene Corp Details
HMPL-653 HMPL-653 Phase 1 Clinical Hutchison Huangpu Medicine (Shanghai) Co Ltd Giant Cell Tumor of Tendon Sheath; Solid tumours Details
Axatilimab SNDX-6352; UCB-6352 Ucb, Incyte Corp Details
Edicotinib JNJ-244; JNJ-527; PRV-6527; JNJ-40346527 Johnson & Johnson Details
Derazantinib ARQ-087.2HCl; AQ-14741087; ARQ-087; BAL-087 Phase 1 Clinical Arqule Inc Biliary Tract Neoplasms; Carcinoma, Transitional Cell; Cholangiocarcinoma; Urogenital Neoplasms Details
APL-102 APL-102; CBT-102 Phase 1 Clinical Apollomics Solid tumours Details
AMG-820 AMG-820 Amgen Inc Details
ARRY-382 ARRY-382 Celgene Corp, Array Biopharma Details
Simmitinib hydrochloride SOMCL-15-290 Phase 1 Clinical Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Solid tumours Details
LY-3022855 IMC-CS4; LY-3022855 Eli Lilly And Company Details
Q-702 Q-702 Phase 2 Clinical Qurient Co Ltd Liver Neoplasms; Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Neoplasms; Uterine Cervical Neoplasms; Neoplasm Metastasis Details
Tinengotinib TT-00420 Phase 2 Clinical TransThera Sciences (Nanjing) Inc Solid tumours; Biliary Tract Neoplasms; Stomach Neoplasms; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Sarcoma; Cholangiocarcinoma; Prostatic Neoplasms; Breast Neoplasms; Thyroid Neoplasms; Gallbladder Neoplasms Details
Recombinant human GM-CSF oncolytic herpes simplex virus type 2 (OH2) OH-2; BS-001; oHSV-2 Phase 2 Clinical Wuhan Binhui Biotechnology Co Ltd Respiratory Distress Syndrome, Adult; Melanoma; Lung Neoplasms; Fallopian Tube Neoplasms; Lymphoma; Gliosarcoma; Peritoneal Neoplasms; Colorectal Neoplasms; Sarcoma; Osteosarcoma; Breast Neoplasms; Prostatic Neoplasms; Urinary Bladder Neoplasms; Digestive System Neoplasms; Central Nervous System Neoplasms; Leukemia; Uveal melanoma; Neoplasms; Colonic Neoplasms; Glioblastoma; Pancreatic Neoplasms; Rectal Neoplasms; Esophageal Neoplasms; Carcinoma, Renal Cell; Solid tumours; Head and Neck Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Hematologic Diseases; Ovarian Neoplasms Details
AC-708 AC-708; PLX-73086 Daiichi Sankyo Co Ltd Details
PLX-7486 PLX-7486; PLX7486-TsOH Daiichi Sankyo Co Ltd Details
Vimseltinib DCC-3014 Phase 3 Clinical Deciphera Giant Cell Tumor of Tendon Sheath; Synovitis, Pigmented Villonodular; Neoplasms Details
Cilmostim CSF-1 Phase 3 Clinical Pfizer Pharmaceuticals Ltd (China) Presbyopia Details
NMS-03592088 NMS-P088; NMS-03592088 Phase 2 Clinical Nerviano Medical Sciences Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
Cabiralizumab FPA-008; ONO-4687; BMS-986227 Phase 2 Clinical Five Prime Therapeutics Inc Giant Cell Tumor of Tendon Sheath; Ovarian Neoplasms; Head and Neck Neoplasms; Solid tumours; Biliary Tract Neoplasms; Lymphoma, T-Cell, Peripheral; Synovitis, Pigmented Villonodular; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Arthritis, Rheumatoid; Glioma; Carcinoma, Non-Small-Cell Lung; Melanoma Details
ABSK-021 ABSK-021 Phase 1 Clinical ABbisko Therapeutics Co Ltd Giant Cell Tumor of Tendon Sheath; Solid tumours; Triple Negative Breast Neoplasms; Graft vs Host Disease; Pancreatic Neoplasms; Neoplasms; Sarcoma; Lung Neoplasms; Amyotrophic Lateral Sclerosis Details
AMB-05X AMB-05X Phase 2 Clinical Amgen Inc Giant Cell Tumor of Tendon Sheath; Synovitis, Pigmented Villonodular; Idiopathic Pulmonary Fibrosis; Testicular Neoplasms Details
Chiauranib CS-2164 Phase 3 Clinical Shenzhen Chipscreen Biosciences Co Ltd Ovarian Neoplasms; Solid tumours; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Neoplasms; Sarcoma; Lymphoma, Non-Hodgkin; Carcinoma, Hepatocellular Details
Emactuzumab RG-7155; 6FY6EI1X8R; RO-5509554 Phase 3 Clinical F. Hoffmann-La Roche Ltd Head and Neck Neoplasms; Solid tumours; Carcinoma; Neoplasms; Prostatic Neoplasms; Testicular Neoplasms; Carcinoma, Squamous Cell; Lymphoma, Non-Hodgkin Details

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