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Rabbit Angiopoietin-2 Protein, His Tag (Cat. No. AN2-R52H4) captured on CM5 chip via anti-His antibody can bind Human TIE2, Fc Tag (Cat. No. TI2-H5255) with an affinity constant of 43.9 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
| Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
|---|---|---|---|---|---|---|---|---|---|---|
| Faricimab | RO-6867461; RG-7716 | Approved | F. Hoffmann-La Roche Ltd, Genentech Inc | Vabysmo, 罗视佳 | United States | Wet Macular Degeneration; Diabetic macular oedema | Genentech Inc | 2022-01-28 | Polypoidal choroidal vasculopathy; Choroid Diseases; Macular Edema; Vision Disorders; Retinal Diseases; Wet Macular Degeneration; Diabetic macular oedema; Diabetes Complications; Choroidal Neovascularization; Myopia; Retinal Vein Occlusion; Macular Degeneration; Diabetes Mellitus; Diabetic Retinopathy | Details |
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| XMVA09 | XMVA-09; XMVA-09 (AAV载体基因治疗药物) | Phase 3 Clinical | Starry Gene | Retinal Dysplasia; Wet Macular Degeneration; Diabetic macular oedema | Details |
| Trebananib | AMG-386; 20060439 | Phase 2 Clinical | Amgen Inc, Takeda Pharmaceutical Co Ltd | Fallopian Tube Neoplasms; Carcinoma, Adenosquamous; Sarcoma; Breast Neoplasms; Brain Neoplasms; Prostatic Neoplasms; Peritoneal Neoplasms; Gliosarcoma; Genital Neoplasms, Female; Colorectal Neoplasms; Endometrial Neoplasms; Adenocarcinoma, Clear Cell; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Lung Neoplasms; Uterine Neoplasms; Carcinoma, Endometrioid; Neoplasm Metastasis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms; Glioblastoma; Ovarian Neoplasms; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Carcinoma, Renal Cell; Renal Insufficiency; Hemangiosarcoma; Rectal Neoplasms; Carcinoma; Leukemia, Myelomonocytic, Acute; Solid tumours; Carcinoma, Transitional Cell; Neoplasms; Colonic Neoplasms; Kidney Diseases; Sarcoma, Endometrial Stromal; Leukemia, Megakaryoblastic, Acute; Oligodendroglioma; Central Nervous System Neoplasms; Neuroendocrine Tumors | Details |
| EXG102-031 | EXG102-031; EXG102-031 (rAAV-based gene therapy) | Phase 2 Clinical | Hangzhou Jiayin Biotechnology Co Ltd | Wet Macular Degeneration; Macular Degeneration | Details |
| Y-400 | Y-400 | Phase 2 Clinical | Wuhan Yzy Biopharma Co Ltd | Wet Macular Degeneration; Diabetic macular oedema; Macular Degeneration | Details |
| Zifibancimig | RO-7250284 | Phase 2 Clinical | F. Hoffmann-La Roche Ltd | Macular Degeneration | Details |
| BI-836880 | BI-836880 | Phase 2 Clinical | Ablynx Nv, C.H. Boehringer Sohn Ag & Co. Kg | Squamous Cell Carcinoma of Head and Neck; Neoplasms; Wet Macular Degeneration; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular | Details |
| Vanucizumab | RG-7221; RO-5520985; B800Z06O8K (UNII code) | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Solid tumours; Neoplasms; Colorectal Neoplasms | Details |
| Zansecimab | LY-3127804 | Phase 1 Clinical | Eli Lilly And Company | Solid tumours; Pneumonia; Coronavirus Disease 2019 (COVID-19) | Details |
| MEDI-3617 | ANG-2-mAb; MEDI-3617; Anti-ANG-2-mAb | Phase 1 Clinical | Medimmune | Ovarian Neoplasms; Solid tumours; Melanoma | Details |
| IBI-324 | IBI-324 | Phase 1 Clinical | Innovent Biologics (Usa), Inc | Diabetic macular oedema | Details |
| EB-105 | EB-105 | Phase 1 Clinical | Eluminex Biosciences (Suzhou) Ltd | Diabetic macular oedema; Diabetic Retinopathy | Details |
| ASKG-712 | ASKG-712; AM-712 | Phase 1 Clinical | Askgene Pharma | Wet Macular Degeneration; Diabetic macular oedema; Macular Degeneration | Details |
| RG-6120 | RG-6120 | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Macular Degeneration | Details |
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