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Rabbit Angiopoietin-2 Protein, His Tag (Cat. No. AN2-R52H4) captured on CM5 chip via anti-His antibody can bind Human TIE2, Fc Tag (Cat. No. TI2-H5255) with an affinity constant of 43.9 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
---|---|---|---|---|---|---|---|---|---|---|
Faricimab | RO-6867461; RG-7716 | Approved | F. Hoffmann-La Roche Ltd, Genentech Inc | Vabysmo, 罗视佳 | United States | Diabetic macular oedema; Wet Macular Degeneration | Genentech Inc | 2022-01-28 | Polypoidal choroidal vasculopathy; Macular Edema; Choroid Diseases; Vision Disorders; Retinal Diseases; Diabetic macular oedema; Wet Macular Degeneration; Diabetes Complications; Macular Degeneration; Diabetes Mellitus; Retinal Vein Occlusion; Diabetic Retinopathy; Choroidal Neovascularization | Details |
Faricimab | RO-6867461; RG-7716 | Approved | F. Hoffmann-La Roche Ltd, Genentech Inc | Vabysmo, 罗视佳 | United States | Diabetic macular oedema; Wet Macular Degeneration | Genentech Inc | 2022-01-28 | Polypoidal choroidal vasculopathy; Macular Edema; Choroid Diseases; Vision Disorders; Retinal Diseases; Diabetic macular oedema; Wet Macular Degeneration; Diabetes Complications; Macular Degeneration; Diabetes Mellitus; Retinal Vein Occlusion; Diabetic Retinopathy; Choroidal Neovascularization | Details |
Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
---|---|---|---|---|---|
Trebananib | AMG-386; 20060439 | Phase 2 Clinical | Amgen Inc, Takeda Pharmaceutical Co Ltd | Lung Neoplasms; Prostatic Neoplasms; Brain Neoplasms; Sarcoma; Carcinoma, Adenosquamous; Peritoneal Neoplasms; Colorectal Neoplasms; Genital Neoplasms, Female; Gliosarcoma; Fallopian Tube Neoplasms; Breast Neoplasms; Uterine Neoplasms; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Endometrial Neoplasms; Neoplasm Metastasis; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Colonic Neoplasms; Solid tumours; Leukemia, Myeloid; Leukemia, Erythroblastic, Acute; Carcinoma; Rectal Neoplasms; Carcinoma, Renal Cell; Hemangiosarcoma; Neoplasms; Ovarian Neoplasms; Kidney Diseases; Glioblastoma; Leukemia, Myelomonocytic, Acute; Central Nervous System Neoplasms; Neuroendocrine Tumors; Leukemia, Megakaryoblastic, Acute; Oligodendroglioma; Sarcoma, Endometrial Stromal | Details |
EXG102-031 | EXG102-031; EXG102-031 (rAAV-based gene therapy) | Phase 2 Clinical | Hangzhou Jiayin Biotechnology Co Ltd | Wet Macular Degeneration; Macular Degeneration | Details |
XMVA09 | XMVA-09; XMVA-09 (AAV载体基因治疗药物) | Phase 2 Clinical | Starry Gene | Wet Macular Degeneration | Details |
Y-400 | Y-400 | Phase 2 Clinical | Wuhan Yzy Biopharma Co Ltd | Wet Macular Degeneration; Diabetic macular oedema; Macular Degeneration | Details |
BI-836880 | BI-836880 | Phase 2 Clinical | Ablynx Nv | Neoplasms; Wet Macular Degeneration | Details |
Vanucizumab | RG-7221; RO-5520985; B800Z06O8K (UNII code) | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Solid tumours; Neoplasms; Colorectal Neoplasms | Details |
Zansecimab | LY-3127804 | Phase 1 Clinical | Eli Lilly And Company | Solid tumours; Pneumonia; Coronavirus Disease 2019 (COVID-19) | Details |
MEDI-3617 | ANG-2-mAb; MEDI-3617; Anti-ANG-2-mAb | Phase 1 Clinical | Medimmune | Ovarian Neoplasms; Solid tumours; Melanoma | Details |
IBI-324 | IBI-324 | Phase 1 Clinical | Innovent Biologics (Usa), Inc | Diabetic macular oedema | Details |
ASKG-712 | ASKG-712; AM-712 | Phase 1 Clinical | Askgene Pharma | Diabetic macular oedema; Wet Macular Degeneration; Macular Degeneration | Details |
RG-6120 | RG-6120 | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Macular Degeneration | Details |
Zifibancimig | RO-7250284 | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Macular Degeneration | Details |
Trebananib | AMG-386; 20060439 | Phase 2 Clinical | Amgen Inc, Takeda Pharmaceutical Co Ltd | Lung Neoplasms; Prostatic Neoplasms; Brain Neoplasms; Sarcoma; Carcinoma, Adenosquamous; Peritoneal Neoplasms; Colorectal Neoplasms; Genital Neoplasms, Female; Gliosarcoma; Fallopian Tube Neoplasms; Breast Neoplasms; Uterine Neoplasms; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Endometrial Neoplasms; Neoplasm Metastasis; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Colonic Neoplasms; Solid tumours; Leukemia, Myeloid; Leukemia, Erythroblastic, Acute; Carcinoma; Rectal Neoplasms; Carcinoma, Renal Cell; Hemangiosarcoma; Neoplasms; Ovarian Neoplasms; Kidney Diseases; Glioblastoma; Leukemia, Myelomonocytic, Acute; Central Nervous System Neoplasms; Neuroendocrine Tumors; Leukemia, Megakaryoblastic, Acute; Oligodendroglioma; Sarcoma, Endometrial Stromal | Details |
EXG102-031 | EXG102-031; EXG102-031 (rAAV-based gene therapy) | Phase 2 Clinical | Hangzhou Jiayin Biotechnology Co Ltd | Wet Macular Degeneration; Macular Degeneration | Details |
XMVA09 | XMVA-09; XMVA-09 (AAV载体基因治疗药物) | Phase 2 Clinical | Starry Gene | Wet Macular Degeneration | Details |
Y-400 | Y-400 | Phase 2 Clinical | Wuhan Yzy Biopharma Co Ltd | Wet Macular Degeneration; Diabetic macular oedema; Macular Degeneration | Details |
BI-836880 | BI-836880 | Phase 2 Clinical | Ablynx Nv | Neoplasms; Wet Macular Degeneration | Details |
Vanucizumab | RG-7221; RO-5520985; B800Z06O8K (UNII code) | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Solid tumours; Neoplasms; Colorectal Neoplasms | Details |
Zansecimab | LY-3127804 | Phase 1 Clinical | Eli Lilly And Company | Solid tumours; Pneumonia; Coronavirus Disease 2019 (COVID-19) | Details |
MEDI-3617 | ANG-2-mAb; MEDI-3617; Anti-ANG-2-mAb | Phase 1 Clinical | Medimmune | Ovarian Neoplasms; Solid tumours; Melanoma | Details |
IBI-324 | IBI-324 | Phase 1 Clinical | Innovent Biologics (Usa), Inc | Diabetic macular oedema | Details |
ASKG-712 | ASKG-712; AM-712 | Phase 1 Clinical | Askgene Pharma | Diabetic macular oedema; Wet Macular Degeneration; Macular Degeneration | Details |
RG-6120 | RG-6120 | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Macular Degeneration | Details |
Zifibancimig | RO-7250284 | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Macular Degeneration | Details |
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