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Your Position: Home > Angiopoietin-2


Brief Information

Target Synonym:ANGPT2,Angiopoietin 2,ANG-2,Angiopoietin-2B,Angiopoietin-2a,Angiopoietin-2,Tie2-Ligand,AGPT2,ANG2
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Approved

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Part of Bioactivity data

 Angiopoietin-2 SPR

Rabbit Angiopoietin-2 Protein, His Tag (Cat. No. AN2-R52H4) captured on CM5 chip via anti-His antibody can bind Human TIE2, Fc Tag (Cat. No. TI2-H5255) with an affinity constant of 43.9 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

 Angiopoietin-2 ELISA

Immobilized Human TIE2, Fc Tag (Cat. No. TI2-H5255) at 5 μg/mL (100 μL/well) can bind Biotinylated Human Angiopoietin-2 Protein, His,Avitag (Cat. No. AN2-H82E9) with a linear range of 0.005-0.156 μg/mL (QC tested).

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Synonym Name



Angiopoietin-2 is also known as ANGPT2, AGPT2, ANG2, and is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Ang2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. It is particularly abundant in vascular endothelial cells (EC) where it is stored in intracellular Weibel Palade bodies. Both Ang2 and the related Angiopoietin1 (Ang1) are ligands for the receptor tyrosine kinase Tie 2. Ang2 functions as a proangiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. Ang2 is required for postnatal vascular remodeling, and it cooperates with Ang1 during lymphatic vessel development. It mediates the upregulation of ICAM1 and VCAM1 on EC, which facilitates the adhesion of leukocytes during inflammation. Ang2 competitively inhibit Ang1-induced endothelial cell responses mediated by Tie2, and reduces vascular integrity. But the role of Ang2 is controversial since the opposite outcomes has been reported in other studies. Over-expression of Ang2 disrupts the vascular remodeling, induce endothelial cell apoptosis, and may play an important regulating role in tumor angiogenesis. Ang2 also promotes the neuronal differentiation and migration of subventricular zone progenitor cells.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Faricimab RG-7716; RO-6867461 Approved F. Hoffmann-La Roche Ltd, Genentech Inc Vabysmo United States Diabetic macular oedema; Wet Macular Degeneration Genentech Inc 2022-01-28 Macular Edema; Choroid Diseases; Diabetic macular oedema; Wet Macular Degeneration; Diabetes Complications; Diabetic Retinopathy; Diabetes Mellitus; Retinal Vein Occlusion; Macular Degeneration; Choroidal Neovascularization Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
RG-6120 RG-6120 Phase 1 Clinical F. Hoffmann-La Roche Ltd Macular Degeneration Details
BI-836880 BI-836880 Phase 2 Clinical Ablynx Nv Neoplasms; Wet Macular Degeneration Details
MEDI-3617 ANG-2-mAb; MEDI-3617; Anti-ANG-2-mAb Phase 1 Clinical Medimmune Ovarian Neoplasms; Solid tumours; Melanoma Details
IBI-324 IBI-324 Phase 1 Clinical Innovent Biologics (Usa), Inc Diabetic macular oedema Details
RO-7250284 RO-7250284 Phase 1 Clinical F. Hoffmann-La Roche Ltd Macular Degeneration Details
Trebananib AMG-386; 20060439 Phase 2 Clinical Amgen Inc, Takeda Pharmaceutical Co Ltd Fallopian Tube Neoplasms; Breast Neoplasms; Brain Neoplasms; Prostatic Neoplasms; Sarcoma; Peritoneal Neoplasms; Colorectal Neoplasms; Genital Neoplasms, Female; Gliosarcoma; Endometrial Neoplasms; Carcinoma, Adenosquamous; Lung Neoplasms; Uterine Neoplasms; Leukemia, Myeloid, Acute; Leukemia, Monocytic, Acute; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Gastrointestinal Neoplasms; Neoplasms; Solid tumours; Leukemia, Myeloid; Leukemia, Erythroblastic, Acute; Carcinoma, Renal Cell; Carcinoma; Rectal Neoplasms; Hemangiosarcoma; Colonic Neoplasms; Ovarian Neoplasms; Kidney Diseases; Leukemia, Myelomonocytic, Acute; Glioblastoma; Sarcoma, Endometrial Stromal; Central Nervous System Neoplasms; Neuroendocrine Tumors; Leukemia, Megakaryoblastic, Acute; Oligodendroglioma Details
Vanucizumab RG-7221; RO-5520985; B800Z06O8K (UNII code) Phase 1 Clinical F. Hoffmann-La Roche Ltd Solid tumours; Neoplasms; Colorectal Neoplasms Details
EXG102-031 EXG102-031; EXG102-031 (rAAV-based gene therapy) Phase 1 Clinical Macular Degeneration Details
XMVA09 XMVA-09 (AAV载体基因治疗药物); XMVA-09 Phase 1 Clinical Starry Gene Wet Macular Degeneration Details
ASKG-712 AM-712; ASKG-712 Phase 1 Clinical Askgene Pharma Wet Macular Degeneration; Macular Degeneration Details

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