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Your Position: Home > Cathepsin S

Cathepsin S

Brief Information

Name:Cathepsin S
Target Synonym:EC:3.4.22.27,Cathepsin S,CTSS,EC 3.4.22,EC 3.4.22.27
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Cat. No. Species Product Description Structure Purity Feature
CTS-H52H9 Human Human Cathepsin S / CTSS Protein, His Tag (active enzyme, MALS verified)
CTS-H52H9-structure
CTS-H52H9-sds

Part of Bioactivity data

CTS-H52H9-MALS-HPLC
Human Cathepsin S, His Tag (Cat. No. ) MALS images

The purity of Human Cathepsin S, His Tag (Cat. No. CTS-H52H9) is more than 90% and the molecular weight of this protein is around 70-92 kDa verified by SEC-MALS.

Bioactivity

Measured by its ability to cleave the fluorogenic peptide substrate, Mca­RPKPVE­Nval­WRK(Dnp)­NH2. The specific activity is >1200 pmol/min/µg, as measured under the described conditions (QC tested).

Synonym Name

CTSS,Cathepsin S

Background

Cathepsin S is also known as CTSS, which is a member of the peptidase C1 family. Cathepsin S is a lysosomal cysteine protease that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. Cathepsin S can function as an elastase over a broad pH range in alveolar macrophages. The catalytic activity of cathepsin S is similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.

Clinical and Translational Updates

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