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Cathepsin S

Cathepsin S Molecule Information

Name:Cathepsin S
Target Synonym:CTSS;Cathepsin S
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:13
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
CTS-H5224 Human Human Cathepsin S / CTSS Protein, His Tag

Cathepsin S Molecule Synonym Name

CTSS,Cathepsin S

Cathepsin S Molecule Background

Cathepsin S is also known as CTSS, which is a member of the peptidase C1 family. Cathepsin S is a lysosomal cysteine protease that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. Cathepsin S can function as an elastase over a broad pH range in alveolar macrophages. The catalytic activity of cathepsin S is similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.

Cathepsin S References

Cathepsin S Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
VBY-036 VBY-036,VBY036 Phase Ⅰ ViroBay Neuropathic pain, Crohn's disease Details
RWJ-445380 RWJ-445380 Phase Ⅱ Johnson & Johnson Plaque psoriasis, Rheumatoid arthritis (RA) Details
AM-3840 AM-3840 Preclinical Amura Therapeutics Neuropathic pain, Rheumatoid arthritis (RA) Details
Cz-007 Preclinical Merck Trypanosoma cruzi infection Details
VBY-825 VBY-106; VBY-285; VBY-825 Preclinical ViroBay Neuropathic pain, Bone cancer, Autoimmune diseases, Alzheimer's disease (AD) Details
VBY-129 VBY-129,VBY129 Phase Ⅰ ViroBay Neuropathic pain, Crohn's disease Details
SAR-114137 SAR 114137; SAR114137 Phase Ⅰ Sanofi Neuropathic pain, Pain Details
VBY-891 VBY-891,VBY891 Phase Ⅰ ViroBay, Leo Pharma Neuropathic pain, Psoriasis Details
Petesicatib RG-7625; RO-5459072 Phase Ⅱ Roche Psoriasis, Sjoegren's syndrome Details
LY-3000328 LY-3000328,LY3000328 Phase Ⅰ Lilly Abdominal aortic aneurysm Details
MIV-247 MIV-247,MIV 247,MIV247 Preclinical Medivir Neuropathic pain, Autoimmune diseases, Multiple sclerosis (MS), Rheumatoid arthritis (RA) Details
CRA-028129 CRA-028129 Phase Ⅰ Celera, Bayer Psoriasis Details
RG-7236 RG7236; RG 7236 Phase Ⅰ Roche Cardiovascular disorders Details

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