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Fas Ligand

Fas Ligand Molecule Information

Name:Soluble Fas ligand
Target Synonym:TNFSF6;Fas antigen ligand;CD_antigen=CD178;Apoptosis antigen ligand;sFasL;APT1LG1 ;FASLG;Tumor necrosis factor ligand superfamily member 6;CD95-L;FasL intracellular domain;CD95 ligand;Soluble Fas ligand;Receptor-binding FasL ectodomain;Fas ligand;CD95L;Fa
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
FAL-H5241 Human Human Fas Ligand / TNFSF6 Protein, His Tag
FAL-H5241-structure
FAL-H5241-sds
FAL-H5241-elisa_1

Fas Ligand Molecule Synonym Name

FASLG,ALPS1B,APT1LG1,CD178,CD95L,FASL,TNFSF6

Fas Ligand Molecule Background

Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.

Fas Ligand References

Fas Ligand Related Molecule

Fas

Fas Ligand Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Fasaret AP-300 Phase Ⅲ ApopLogic Solid tumours Details
Asunercept CAN-008; APG-101,CAN008; APG101 Phase Ⅱ Apogenix, CANbridge Life Sciences Myelodysplastic syndrome (MDS), Glioblastoma Details

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