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Your Position: Home > Fas Ligand

Fas Ligand

Brief Information

Name:Soluble Fas ligand
Target Synonym:CD95L,Fas ligand,SPA,FASLG,Soluble Fas ligand,sFasL,Receptor-binding FasL ectodomain,FasL ICD,TNFSF6,Apoptosis antigen ligand,Tumor necrosis factor ligand superfamily member 6,APL,CD178,Fas Ligand (TNF Superfamily, Member 6),Fas Antigen Ligand,CD95 Ligand
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
FAL-H5241 Human Human Fas Ligand / TNFSF6 Protein, His Tag, active trimer (MALS verified)
FAL-H5241-structure
FAL-H5241-sds
FAL-H5241-elisa_1

Part of Bioactivity data

FAL-H5241-MALS-HPLC
Human Fas Ligand, His Tag, active trimer (Cat. No. ) MALS images

The purity of Human Fas Ligand, His Tag, active trimer (Cat. No. FAL-H5241) was more than 90% and the molecular weight of this protein is around 70-80 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human Fas Ligand, His Tag, active trimerHuman Fas Ligand, His Tag, active trimer (Cat. No. FAL-H5241) ELISA bioactivity

Immobilized Human Fas Ligand, His Tag, active trimer (Cat. No. FAL-H5241) at 2 μg/mL (100 μL/well) can bind Human Fas Protein, Fc Tag (MALS verified) (Cat. No. FAS-H5252) with a linear range of 0.3-5 ng/mL (QC tested).

FAL-H5241-ELISA
Human Fas Ligand, His Tag, active trimerHuman Fas Ligand, His Tag, active trimer (Cat. No. FAL-H5241) ELISA bioactivity

Immobilized Human Fas Ligand, His Tag, active trimer (Cat. No. FAL-H5241) at 2 μg/mL (100 μL/well) can bind Human Fas Protein, Fc Tag (MALS verified) (Cat. No. FAS-H5252) with a linear range of 0.3-5 ng/mL (QC tested).

Synonym Name

FASLG,ALPS1B,APT1LG1,CD178,CD95L,FASL,TNFSF6

Background

Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.

Clinical and Translational Updates

Related Molecule

Fas

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Asunercept CAN-008; APG-101 Phase 2 Clinical Apogenix Glioblastoma; Myelodysplastic Syndromes; Coronavirus Disease 2019 (COVID-19) Details

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