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FGF basic

Brief Information

Name:Fibroblast growth factor 2
Target Synonym:FGF-2,Heparin-binding growth factor 2,Basic fibroblast growth factor,FGFB,bFGF,HBGF-2,FGF2,Fibroblast Growth Factor 2 (Basic),Basic Fibroblast Growth Factor BFGF,Prostatropin,Fibroblast Growth Factor 2
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
FGC-H81E3 Human Biotinylated Human FGF basic Protein, Avitag™,His Tag (MALS verified)
FGC-H81E3-structure
FGC-H81E3-sds
FGC-H81E3-elisa_1
BFF-H4117 Human Human FGF basic Protein, Tag Free
BFF-H4117-structure
BFF-H4117-sds
BFF-H4117-elisa_1
BFF-H4117-elisa_2

Part of Bioactivity data

BFF-H4117-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human FGF basic, Tag Free (Cat. No. BFF-H4117) stimulates proliferation of HUVEC in the range of 0-20 ng/mL. The EC50 for this effect is 0.416-0.630 ng/mL (Routinely tested).

BFF-H4117-SPR
Human_FcRn_Heterodimer_Protein_SPR

Immobilized Human FGF basic, Tag Free (Cat. No. BFF-H4117) on CM5 Chip can bind Heparin with an affinity constant of 8.37 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

BFF-H4117-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Heparin on SA Biosensor, can bind Human FGF basic, Tag Free (Cat. No. BFF-H4117) with an affinity constant of 6.27 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

FGF2,BFGF,FGFB,FGF basic,HBGF-2

Background

FGF basic is a member of the FGF family of at least 23 related mitogenic proteins which show 35-60% amino acid conservation. FGF acidic and basic, unlike the other members of the family, lack signal peptides and are apparently secreted by mechanisms other than the classical protein secretion pathway. FGF basic has been isolated from a number of sources, including neural tissue, pituitary, adrenal cortex, corpus luteum, and placenta. This factor contains four cysteine residues, but reduced FGF basic retains full biological activity, indicating that disulfide bonds are not required for this activity. bFGF is a critical component of human embryonic stem cell culture medium; the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. It has been demonstrated to induce gremlin expression which in turn is known to inhibit the induction of differentiation by bone morphogenetic proteins. It is necessary in mouse-feeder cell dependent culture systems, as well as in feeder and serum-free culture systems.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Pentosan Polysulfate Sodium PPS; PZ-68; SP-54; AK-150 Approved Ivax, Teva Elmiron, Zilosul EU Cystitis, Interstitial Bene-Arzneimittel Gmbh 1996-09-26 Pain; Cystitis, Interstitial; Prostatitis; Osteoarthritis, Knee Details
Thalidomide NSC-66847; NSC-527179; K-17; VP-02 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Japan Leprosy, Lepromatous Fujimoto Pharmaceutical 1982-01-01 HIV Infections; Spondylitis, Ankylosing; Myelodysplastic Syndromes; Idiopathic Pulmonary Fibrosis; Multiple Myeloma; HIV Wasting Syndrome; Erythema Nodosum; Leprosy, Lepromatous; Carcinoma, Hepatocellular Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
RBM-007 RBM-007; ID3 (21); APT-F2 Phase 2 Clinical Ribomic Macular Degeneration Details
Fibroblast growth factor 2 gene therapy (ID Pharma) SEV-10101; DVC-10101 Phase 2 Clinical Dnavec Ischemia; Peripheral Arterial Disease Details
Muparfostat sodium PI-88 Phase 3 Clinical Australian National University Liver Neoplasms; Solid tumours; Prostatic Neoplasms; Lung Neoplasms; Carcinoma, Hepatocellular; Melanoma; Carcinoma, Non-Small-Cell Lung Details

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