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FGF basic

FGF basic Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
BFF-H4117 Human Human FGF basic Protein, Tag Free
BFF-H4117-structure
BFF-H4117-sds
BFF-H4117-elisa_1
BFF-H4117-elisa_2

FGF basic Part of Bioactivity data

BFF-H4117-SPR
Human_FcRn_Heterodimer_Protein_SPR

Immobilized Human FGF basic, Tag Free (Cat. No. BFF-H4117) on CM5 Chip can bind Heparin with an affinity constant of 8.37 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

BFF-H4117-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Heparin on SA Biosensor, can bind Human FGF basic, Tag Free (Cat. No. BFF-H4117) with an affinity constant of 1.88 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

FGF basic Molecule Synonym Name

FGF2,BFGF,FGFB,FGF basic,HBGF-2

FGF basic Molecule Background

FGF basic is a member of the FGF family of at least 23 related mitogenic proteins which show 35-60% amino acid conservation. FGF acidic and basic, unlike the other members of the family, lack signal peptides and are apparently secreted by mechanisms other than the classical protein secretion pathway. FGF basic has been isolated from a number of sources, including neural tissue, pituitary, adrenal cortex, corpus luteum, and placenta. This factor contains four cysteine residues, but reduced FGF basic retains full biological activity, indicating that disulfide bonds are not required for this activity. bFGF is a critical component of human embryonic stem cell culture medium; the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. It has been demonstrated to induce gremlin expression which in turn is known to inhibit the induction of differentiation by bone morphogenetic proteins. It is necessary in mouse-feeder cell dependent culture systems, as well as in feeder and serum-free culture systems.

FGF basic References

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