Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Flt-3 Ligand

Flt-3 Ligand

Brief Information

Name:Fms-related tyrosine kinase 3 ligand
Target Synonym:Flt3L,SL cytokine,FLT3LG
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

Product ListCompare or Buy

ACRO Quality

Part of Bioactivity data

GMP-FLLH28-Cell-based assay
 Flt-3 Ligand CELL

GMP Human Flt-3 Ligand Protein (Cat. No. GMP-FLLH28) stimulates proliferation of OCI-AML5 cells. The specific activity of GMP Human Flt-3 Ligand Protein is > 5.00 x 10^5 IU/mg, which is calibrated against WHO Reference Reagent FMS-LIKE TYROSINE KINASE 3 LIGAND (NIBSC code: 96/532) (QC tested).

FLL-H5218-Cell-based assay
 Flt-3 Ligand CELL

Human Flt-3 Ligand, premium grade (Cat. No. FLL-H5218) stimulates proliferation of OCI-AML5 cell. The specific activity of Human Flt-3 Ligand, premium grade is > 5.00×10^5 IU/mg, which is calibrated against human WHO-Flt3 Ligand International Standard (NIBSC code: 96/532) (QC tested).

 Flt-3 Ligand ELISA

Immobilized Human Flt-3, Fc Tag (Cat. No. FL3-H5258) at 2 μg/mL (100 μL/well) can bind Biotinylated Human Flt-3 Ligand, His,Avitag (Cat. No. FLL-H82E6) with a linear range of 0.1-4 ng/mL (QC tested).

Flt-3 Ligand MALS images

The purity of Dog Flt-3 Ligand Protein, His Tag (Cat. No. FLD-D52H3) is more than 85% and the molecular weight of this protein is around 46-58 kDa verified by SEC-MALS.

Synonym Name

FLT3LG,FL,FLT3L,Flt3 ligand


FMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is also known as FL, Flt3L and FLT3LG, is an α-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of  N- and O- linked carbohydrates. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation. Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation. FLT3LG is crucial for steady-state pDC and cDC development.  A lack of FLT3L results in low levels of DCs.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
VIB-1116 VIB-1116; AMG 329; HZN-1116 Phase 2 Clinical Viela Bio Inc Autoimmune Diseases; Sjogren's Syndrome Details

This web search service is supported by Google Inc.

Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
+1 888-377-6111
1 Innovation Way, Newark, DE 19711, USA

Leave a message