0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Flt-3 Ligand

Flt-3 Ligand

Flt-3 Ligand Protein Product ListCompare or Buy

By Product Status:
By Product Category:
By Species:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
FLL-M52H4 Mouse Mouse Flt-3 Ligand Protein, His Tag
FLL-M52H4-structure
FLL-M52H4-sds
FLL-M52H4-elisa_1
FLL-H55H7 Human Human Flt-3 Ligand Protein, His Tag
FLL-H55H7-structure
FLL-H55H7-sds
FLL-H55H7-elisa_1
FLL-H5218 Human ActiveMax® Human Flt-3 Ligand Protein, Tag Free
FLL-H5218-structure
FLL-H5218-sds
FLL-H5218-elisa_1
FLL-H5223 Human Human Flt-3 Ligand Protein, His Tag
FLL-H5223-structure
FLL-H5223-sds
FLL-H5223-elisa_1

Flt-3 Ligand Molecule Synonym Name

FLT3LG,FL,FLT3L,Flt3 ligand

Flt-3 Ligand Molecule Background

FMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is also known as FL, Flt3L and FLT3LG, is an ¦Á-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O- linked carbohydrates. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation. Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation. FLT3LG is crucial for steady-state pDC and cDC development. A lack of FLT3L results in low levels of DCs.

Flt-3 Ligand References

This web search service is supported by Google Inc.

totop