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Brief Information

Name:Folate receptor beta
Target Synonym:FOLR1,FRbeta,Folate Receptor Alpha,FBP,Placental folate-binding protein,Folate receptor, fetal/placental,FOLR2,Folate receptor beta,Folate Receptor 2 (Fetal),Folate-Binding Protein, Fetal/Placental,BETA-HFR,FBP/PL-1,FR-Beta,FR-P3,Folate Receptor 2,FRβ
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data


Immobilized Folic acid-BSA on CM5 Chip can bind Biotinylated Human FOLR2, His,Avitag (Cat. No. FO2-H82E8) with an affinity constant of 4.61 nM as determined in a SPR assay (Biacore T200) (Routinely tested).


Immobilized Folic acid-BSA on CM5 Chip can bind Cynomolgus FOLR2 Protein, His Tag (Cat. No. FO2-C52H8) with an affinity constant of 1.5 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name



Folate receptor beta is also known as Folate receptor 2, FBP, FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, and is a member of the folate receptor (FOLR) family. and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is predominantly expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells.  It is upregulated on myeloid leukemias, head and neck squamous cell carcinomas, and several nonepithelial cancers. It is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma.  FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Arfolitixorin ISO-901; 6R-MTHF Phase 3 Clinical Isofol Medical Ab Rectal Neoplasms; Colonic Neoplasms; Osteosarcoma; Colorectal Neoplasms Details
UB-TT170 UB-TT170; UB-TT-170; UB_TT170; UB_TT-170 Phase 1 Clinical Umoja BioPharma Inc Osteosarcoma Details

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