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Brief Information

Name:AXL receptor tyrosine kinase
Target Synonym:AXL Oncogene,EC,JTK11,Tyro7,ARK,Tyrosine-protein kinase receptor UFO,AXL,AXL Receptor Tyrosine Kinase,EC 2.7.10,EC:,UFO,AXL Transforming Sequence/Gene
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:18
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
AXL-H5253 Human Human Axl Protein, Fc Tag
AXL-C52H3 Cynomolgus Cynomolgus Axl Protein, His Tag
AXL-H5226 Human Human Axl Protein, His Tag

Synonym Name



AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Gilteritinib Fumarate ASP-2215 hemifumarate; ASP-2215; 66D-92MGC8M (UNII code) Approved Astellas Pharma Inc Xospata Mainland China Leukemia, Myeloid, Acute Astellas Pharmaceutical (China) Co Ltd 2018-09-21 Solid tumours; Renal Insufficiency; Hepatic Insufficiency; Leukemia, Myeloid, Acute Details
Cabozantinib S-malate BMS-907351; XL-184 Approved Exelixis Inc Cometriq, Cabometyx Japan Carcinoma, Renal Cell Takeda 2012-11-29 Solid tumours; Pain; Stomach Neoplasms; Carcinoma, Renal Cell; Esophageal Neoplasms; Glioblastoma; Kidney Diseases; Prostatic Neoplasms; Colorectal Neoplasms; Astrocytoma; Hepatic Insufficiency; Thyroid Neoplasms; Carcinoma, Neuroendocrine; Lymphoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
NP-01 (Shijiazhuang No.4 Pharmaceutical/Nanjing Nadingfei Medical Technology) NP-01 Phase 1 Clinical Shijiazhuang No.4 Pharmaceutical Co Ltd, Nanjing Nadingfei Pharmaceutical Technology Co Ltd Liver Neoplasms; Stomach Neoplasms; Lung Neoplasms Details
Q-702 Phase 1 Clinical Qurient Co Ltd Solid tumours; Neoplasm Metastasis Details
Dubermatinib TP-0903 Phase 2 Clinical Sumitomo Dainippon Ovarian Neoplasms; Colorectal Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Melanoma; Carcinoma, Non-Small-Cell Lung Details
SLC-391 SLC-391 Phase 1 Clinical Signalchem Lifesciences Neoplasms Details
Glesatinib MG-90265; MGCD-265; MG-90265X; 7Q29OXD98N; MG-90265H9; MG-90265gly Phase 2 Clinical Mirati Therapeutics Carcinoma, Non-Small-Cell Lung Details
Enapotamab vedotin (Genmab) AXL-107-MMAE Phase 2 Clinical Seattle Genetics Inc, Genmab Ovarian Neoplasms; Sarcoma; Endometrial Neoplasms; Thyroid Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Melanoma Details
ONO-7475 ONO-7475 Phase 2 Clinical Ono Pharmaceutical Co Ltd Leukemia; Myelodysplastic Syndromes; Neoplasms; Leukemia, Myeloid, Acute Details
DS-1205 (Daiichi Sankyo Company) DS-1205; DS-1205b; DS-1205c Phase 1 Clinical Daiichi Sankyo Co Ltd Carcinoma, Non-Small-Cell Lung Details
RXDX-106 RXDX-106 Phase 1 Clinical Teva, Daiichi Sankyo Co Ltd Solid tumours; Neoplasms Details
INCB-081776 INCB-81776; INCB-081776 Phase 1 Clinical Incyte Corp Solid tumours Details
BPI-9016 BPI-9016; BPI-9016M Phase 1 Clinical Betta Pharmaceuticals Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details
BA-3011 BA-3011 Phase 2 Clinical Bioatla Leiomyosarcoma; Solid tumours; Pancreatic Neoplasms; Liposarcoma; Sarcoma, Synovial; Osteosarcoma; Sarcoma, Ewing; Sarcoma; Melanoma; Carcinoma, Non-Small-Cell Lung Details
HH-30134 Phase 1 Clinical Solid tumours; Neoplasms Details
Bemcentinib R-428; BGB-324 Phase 2 Clinical Rigel Pharmaceuticals Inc Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Non-alcoholic Fatty Liver Disease; Coronavirus Disease 2019 (COVID-19); Inflammatory Breast Neoplasms; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Idiopathic Pulmonary Fibrosis; Myelodysplastic Syndromes; Adenocarcinoma of Lung; Breast Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details
BGB-149 BGB-149 Phase 1 Clinical Bergenbio Ovarian Neoplasms; Neoplasms Details
Butylidenephthalide BDPH; HK-001; NSC-325307 Phase 2 Clinical Everfront Biotech Co Ltd Glioma; Amyotrophic Lateral Sclerosis Details
PF-07265807 PF-07265807 Phase 1 Clinical Neoplasm Metastasis Details
ADCT-601 ADCT-601 Phase 1 Clinical Adc Therapeutics Solid tumours; Neoplasms Details
S-49076 S-49076 Phase 2 Clinical Servier Glioblastoma; Carcinoma, Non-Small-Cell Lung Details
cancer therapeutics (BerGenBio) BGB-001; BGB-003; BGB-101; BGB-109; BGB-601 Phase 1 Clinical Bergenbio Pancreatic Neoplasms Details
Ningetinib Tosylate CT-053; CT-053-PTSA Phase 2 Clinical Hec Pharm Co Ltd Solid tumours; Intestinal Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Leukemia, Myeloid, Acute; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details

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