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Axl

Axl

Axl Overview

Molecule Name
AXL receptor tyrosine kinase
Synonyms
AXL,UFO
Drug Development Progress
Drugs in Clinical Trials27
Approved Drugs2
Highest Development StageApproved
Target Synonym
EC:2.7.10.1，EC 2.7.10，UFO，AXL Transforming Sequence/Gene，AXL Oncogene，EC 2.7.10.1，JTK11，Tyro7，ARK，Tyrosine-protein kinase receptor UFO，AXL，AXL Receptor Tyrosine Kinase
Background
AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.

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Project Cooperation

Project NameDrug TypeTherapeutic AreaIndicationStageRights Area
AXL inhibitorSmall moleculeOncology/CancerSTK11_mut NSCLC,other cancersPhase IGlobal
Project Name
AXL inhibitor
Drug Type
Small molecule
Therapeutic Area
Oncology/Cancer
Indication
STK11_mut NSCLC,other cancers
Stage
Phase I
Rights Area
Global