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Your Position: Home > HMGB1

HMGB1

HMGB1 Protein Product ListCompare or Buy

Product> Filter Results

Cat. No.	Species	Product Description
HM1-M52H6	Mouse	Mouse HMGB1 Protein, His Tag
HM1-H5255	Human	Human HMGB1 Protein, Mouse IgG2a Fc Tag, low endotoxin
HM1-H5220	Human	Human HMGB1 Protein, His Tag

HMGB1 Part of Bioactivity data

HM1-H5255-Cell-based assay

Human FcRn Heterodimer Protein Cell_Base

Human HMGB1, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. HM1-H5255) stimulates production of TNF-α in Raw-246.7 cells. The EC50 for this effect is 13.18 μg/mL (Routinely tested).

Protocol

HM1-H5220-ELISA

Immobilized Human HMGB1, His Tag (Cat. No. HM1-H5220) at 5 μg/mL (100 μL/well) can bind Human RAGE, Fc Tag (Cat. No. AGR-H5253) with a linear range of 0.078-2.5 μg/mL (QC tested).

Protocol

HMGB1 Molecule Synonym Name

HMGB1,HMG1,HMG3,SBP-1

HMGB1 Molecule Background

High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.