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IDH1

Brief Information

Name:Isocitrate dehydrogenase [NADP] cytoplasmic
Target Synonym:Isocitrate Dehydrogenase [NADP] Cytoplasmic,IDH,EC 1.1.1.42,HEL-216,HEL-S-26,IDH1,Cytosolic NADP-Isocitrate Dehydrogenase,NADP(+)-Specific ICDH,IDP,Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic,IDCD,PICD,Isocitrate Dehydrogenase 1 (NADP+), Soluble,Isoci
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
ID1-H51H6 Human Human IDH1 Protein, His Tag (active enzyme, MALS verified)
ID1-H51H6-structure
ID1-H51H6-sds

Part of Bioactivity data

ID1-H51H6-ELISA
Human IDH1, His Tag (Cat. No. ) MALS images

The purity of Human IDH1, His Tag (Cat. No. ID1-H51H6) was more than 85% and the molecular weight of this protein is around 90-100 kDa verified by SEC-MALS.

Bioactivity

Measured by the ability to oxidatively decarboxylate isocitrate to 2-oxoglutarate. The specific activity is >10000 pmol/min/μg, as measured under the described conditions (QC tested).

Synonym Name

IDH1,PICD,IDP

Background

Isocitrate dehydrogenase 1 (IDH1) is also known as Cytosolic NADP-isocitrate dehydrogenase (NADP(+)-specific ICDH), Oxalosuccinate decarboxylase and PICD, which is one of the Isocitrate dehydrogenases that can catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD+ as the electron acceptor and the other NADP+. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.

Clinical and Translational Updates

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