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Your Position: Home > IDH1

IDH1

IDH1 Molecule Information

Name:Isocitrate dehydrogenase [NADP] cytoplasmic
Target Synonym:Oxalosuccinate decarboxylase;Isocitrate dehydrogenase [NADP] cytoplasmic;IDP;Cytosolic NADP-isocitrate dehydrogenase;IDH1;PICD;NADP(+)-specific ICDH;IDH

Number of Launched Drugs:1
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Approved

IDH1 Protein Product ListCompare or Buy

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Cat. No.	Species	Product Description	Structure	Purity	Feature
ID1-H5120	Human	Human IDH1 Protein, His Tag

IDH1 Molecule Synonym Name

IDH1,PICD,IDP

IDH1 Molecule Background

Isocitrate dehydrogenase 1 (IDH1) is also known as Cytosolic NADP-isocitrate dehydrogenase (NADP(+)-specific ICDH), Oxalosuccinate decarboxylase and PICD, which is one of the Isocitrate dehydrogenases that can catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD+ as the electron acceptor and the other NADP+. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.

IDH1 References

IDH1 Public Drug Information

Name	Research Code	Research Phase	Company	First Brand Name	First Approved Country	First Indication	First Approved Company	First Approved Date	Indications	Clinical Trials
Ivosidenib	AG-120,AG120	Approved	Agios Pharmaceuticals, Celgene, CStone Pharmaceuticals	TIBSOVO	fda		AGIOS PHARMS INC	2018-07-20	Acute myeloid Leukemia (AML)	Details

IDH1 Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
BAY-1436032	BAY-1436032	Phase Ⅰ	Bayer	Solid tumours, Acute myeloid Leukemia (AML)	Details
IDH1 peptide vaccine (German Cancer Research Center)		Phase Ⅰ	German cancer research center	Glioma	Details
IDH-305	IDH-305,IDH305	Phase Ⅱ	Novartis	Glioma, Acute myeloid Leukemia (AML), Malignancies	Details
Vorasidenib	AG-881,AG881	Phase Ⅰ	Agios Pharmaceuticals, Celgene	Glioma, Solid tumours, Hematological cancer	Details
DS-1001	DS-1001; DS-1001b	Phase Ⅰ	Daiichi Sankyo	Glioma	Details
Olutasidenib	FT-2102,FT 2102	Phase Ⅱ	FORMA Therapeutics	Myelodysplastic syndrome (MDS), Acute myeloid Leukemia (AML)	Details
HMPL-306	HMPL-306	Phase Ⅰ	Hutchison Medipharma	Solid tumours, Hematological cancer	Details