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Your Position: Home > IDH1

IDH1

IDH1 Molecule Information

Name:Isocitrate dehydrogenase [NADP] cytoplasmic
Target Synonym:Isocitrate Dehydrogenase [NADP] Cytoplasmic,IDH,EC 1.1.1.42,HEL-216,HEL-S-26,IDH1,Cytosolic NADP-Isocitrate Dehydrogenase,NADP(+)-Specific ICDH,IDP,Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic,IDCD,PICD,Isocitrate Dehydrogenase 1 (NADP+), Soluble,Isoci

Number of Launched Drugs:1
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Approved

IDH1 Molecule Synonym Name

IDH1,PICD,IDP

IDH1 Molecule Background

Isocitrate dehydrogenase 1 (IDH1) is also known as Cytosolic NADP-isocitrate dehydrogenase (NADP(+)-specific ICDH), Oxalosuccinate decarboxylase and PICD, which is one of the Isocitrate dehydrogenases that can catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD+ as the electron acceptor and the other NADP+. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.

IDH1 References

IDH1 Public Drug Information

Name	Research Code	Research Phase	Company	First Brand Name	First Approved Country	First Indication	First Approved Company	First Approved Date	Indications	Clinical Trials
Ivosidenib	AG-120; CS-3010	Approved	Celgene Corp, Agios Pharmaceuticals	Tibsovo	United States	Leukemia, Myeloid, Acute	s:25:"Agios Pharmaceuticals Inc";	2018-07-20	Leukemia; Chondrosarcoma; Biliary Tract Neoplasms; Leukemia, Myeloid; Myelodysplastic Syndromes; Cholangiocarcinoma; Hepatic Insufficiency; Bile Duct Neoplasms; Leukemia, Myeloid, Acute; Glioma	Details

IDH1 Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
IDH-305	IDH-305	Phase 2 Clinical	Novartis Pharma Ag	Neoplasms; Leukemia, Myeloid, Acute; Glioma	Details
BAY-1436032	BAY-1436032	Phase 1 Clinical	Bayer Ag	Neoplasms; Leukemia, Myeloid, Acute	Details
IDH1 peptide vaccine (German Cancer Research Center)		Phase 1 Clinical	Deutsches Krebsforschungszentrum, Dkfz	Glioma	Details
DS-1001	DS-1001b; DS-1001	Phase 2 Clinical	Daiichi Sankyo Co Ltd	Glioma	Details
Olutasidenib	FT-2102	Phase 2 Clinical	Forma Therapeutics	Chondrosarcoma; Irritable Bowel Syndrome; Clostridium Infections; Myelodysplastic Syndromes; Glioblastoma; Diarrhea; Leukemia, Myeloid, Acute; Glioma	Details
Vorasidenib	AG-881	Phase 3 Clinical	Celgene Corp, Agios Pharmaceuticals	Hematologic Neoplasms; Biliary Tract Neoplasms; Myelodysplastic Syndromes; Sarcoma; Leukemia, Myeloid, Acute; Glioma	Details
HMPL-306	HMPL-306	Phase 1 Clinical	Hutchison Medipharma Ltd	Hematologic Neoplasms; Solid tumours; Leukemia, Myeloid, Acute	Details
HH-2301		Phase 1 Clinical		Chondrosarcoma; Biliary Tract Neoplasms; Solid tumours; Glioma	Details
LY-3410738	LY-3410738	Phase 1 Clinical	Eli Lilly And Company	Chondrosarcoma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Leukemia, Myelomonocytic, Chronic; Cholangiocarcinoma; Leukemia, Myeloid, Acute; Glioma	Details
TQB-3455	TQB-3455	Phase 1 Clinical	Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd, Lianyungang Runzhong Pharmaceutical Co Ltd, Beijing Sailintai Medicine Technology Co Ltd	Solid tumours; Hematologic Neoplasms; Leukemia, Myeloid, Acute	Details