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Brief Information

Name:Insulin-like growth factor I receptor
Target Synonym:IGF-I receptor,IGF1R,Insulin Like Growth Factor 1 Receptor,Insulin-Like Growth Factor 1 Receptor,Insulin-Like Growth Factor I Receptor,Soluble IGF1R Variant 1,Soluble IGF1R Variant 2,CD221 Antigen,CD221,IGFIR,JTK13,IGFR,Receptor, IGF Type 1,MGC18216
Number of Launched Drugs:6
Number of Drugs in Clinical Trials:17
Lastest Research Phase:Approved

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Part of Bioactivity data


Biotinylated Human IGF-I R, His,Avitag (Cat. No. IGR-H82E3) immobilized on CM5 Chip can bind Human IGF-I, His Tag (Cat. No. IG1-H5245) with an affinity constant of 33.9 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).


Human IGF-I R, His Tag (Cat. No. IGR-H5229) immobilized on CM5 Chip can bind Biotinylated Human IGF-I, His,Avitag (Cat. No.IG1-H82Q6) with an affinity constant of 68 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Synonym Name



The Insulin-like Growth Factor 1 Receptor (IGF1) is also known as CD221, JTK13. and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF1R is make up of two alpha subunits and two beta subunits ,the Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain.The α chains are located extracellularly while the β subunit spans the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R have a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is a 60% homology between IGF1R and the insulin receptor. In response to ligand binding, the α chains induce the tyrosine autophosphorylation of the β chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
IGF-1 (Biogen/Pharmacia & Upjohn) Approved Biogen Inc, Pharmacia & Upjohn Igef Sweden Dwarfism null 1994-01-01 Dwarfism Details
Mecasermin (Astellas/OrphanPacific) Approved Astellas Pharma Inc Somazon Japan Dwarfism; Diabetes Mellitus, Lipoatrophic; Growth hormone deficiency null 1994-10-05 HIV Infections; Diabetes Mellitus, Lipoatrophic; Heart Failure; Myocardial Infarction; Multiple Sclerosis; Lipodystrophy; Dwarfism; Growth hormone deficiency Details
Mecasermin (Ipsen) IGF-1; FK-780; MKN-031 Approved Ipsen Increlex United States Laron Syndrome Ipsen Pharma 2005-08-30 Failure to Thrive; Autism Spectrum Disorder; X-Linked Combined Immunodeficiency Diseases; Phelan-McDermid syndrome; Growth Disorders; Muscular Dystrophy, Duchenne; Laron Syndrome Details
Brigatinib AP-26113 Approved Ariad, Takeda Pharmaceutical Co Ltd Alunbrig United States Carcinoma, Non-Small-Cell Lung Takeda Pharmaceuticals U.S.A. Inc 2017-04-28 Ependymoma; Solid tumours; Carcinoma; Neoplasms; Neurofibromatosis 2; Myofibroma; Lung Neoplasms; Lymphoma, Large-Cell, Anaplastic; Brain metastases; Granuloma, Plasma Cell; Carcinoma, Non-Small-Cell Lung; Meningioma; Neurilemmoma; Neuroma, Acoustic; Sarcoma, Kaposi Details
Ceritinib LDK-378; NVP-LDK378; NVP-LDK378-NX Approved Novartis Pharma Ag 赞可达, Zykadia EU Carcinoma, Non-Small-Cell Lung Novartis Europharm Ltd 2014-04-29 Hepatic Insufficiency; Melanoma; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Brain metastases; Esophageal adenocarcinoma; Granuloma, Plasma Cell; Lymphoma, Large-Cell, Anaplastic; Hematologic Neoplasms; Colorectal Neoplasms; Cholangiocarcinoma; Thyroid Carcinoma, Anaplastic; Neoplasms; Pancreatic Neoplasms; Glioblastoma; Stomach Neoplasms Details
Teprotumumab R-1507; RG-1507; RO-4858696; HZN-001 Approved Genmab A/S, F. Hoffmann-La Roche Ltd Tepezza United States Graves Ophthalmopathy Horizon Therapeutics Ireland 2020-01-21 Neoplasms; Graves Ophthalmopathy; Sarcoma; Breast Neoplasms; Diabetic macular oedema; Scleroderma, Diffuse; Carcinoma, Non-Small-Cell Lung Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
FPI-1434 [225Ac]-FPI-1434; FPX-01 Phase 2 Clinical Fusion Pharma Ovarian Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Neoplasms; Uveal melanoma; Adrenocortical Carcinoma; Breast Neoplasms; Endometrial Neoplasms; Uterine Cervical Neoplasms Details
Picropodophyllin PPP; AXL-1717; NSC-36407 Phase 2 Clinical Axelar Ab Astrocytoma; Carcinoma, Non-Small-Cell Lung Details
124I-CPD-1023-figitumumab 124I-CPD-1028; 125I-CPD-1028; CPD-1028-[124I]; CPD-1028-[125I]; FPX-1028 Phase 1 Clinical Fusion Pharma Neoplasms Details
Teprotumumab biosimilar(Innovent) IBI-311 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Graves Ophthalmopathy Details
lonigutamab ugodotin W-0101 Phase 2 Clinical Pierre Fabre Group Solid tumours Details
Cixutumumab A-12; IMC-A12; LY-3012217; NSC-742460 Phase 2 Clinical Eli Lilly And Company Osteosarcoma; Gliosarcoma; Adenocarcinoma, Bronchiolo-Alveolar; Colorectal Neoplasms; Medullary thyroid cancer (MTC); Neuroblastoma; Gastrinoma; Neurofibrosarcoma; Retinoblastoma; Brain Stem Neoplasms; Breast Neoplasms; Prostatic Neoplasms; Sarcoma; Sarcoma, Ewing; Lymphoma, Mantle-Cell; Liposarcoma; Glucagonoma; Esophageal adenocarcinoma; Neuroectodermal Tumors, Primitive, Peripheral; Adenocarcinoma; Paraganglioma; Melanoma; Breast Neoplasms, Male; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Sarcoma, Alveolar Soft Part; Adrenocortical Carcinoma; Glioma; Rhabdomyosarcoma, Alveolar; Esophageal Squamous Cell Carcinoma; Hemangiopericytoma; Carcinoma, Neuroendocrine; Lung Neoplasms; Pinealoma; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Merkel Cell; Insulinoma; Hemangiosarcoma; Mesenchymoma; Hepatoblastoma; Stomach Neoplasms; Esophageal Neoplasms; Carcinoma; Desmoplastic Small Round Cell Tumor; Kidney Neoplasms; Fibrosarcoma; Chondrosarcoma; Liver Neoplasms; Head and Neck Neoplasms; Leiomy Details
Linsitinib OSI-906; ASP-7487; OSI-906AA Phase 3 Clinical Astellas Pharma Inc, National Cancer Institute Endocrine System Diseases; Paraganglioma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Eye Diseases; Orbital Diseases; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Breast Neoplasms; Prostatic Neoplasms; Sarcoma, Ewing; Graves Ophthalmopathy; Solid tumours; Multiple Myeloma; Adrenocortical Carcinoma; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Skin Neoplasms; Neoplasms; Hashimoto Disease; Carney Complex; Liver Neoplasms; Chondrosarcoma; Thyroid Diseases; Ovarian Neoplasms Details
IGF-1 receptor oligodeoxynucleotide-based immunotherapy (Thomas Jefferson University) Phase 1 Clinical Sidney Kimmel Cancer Center Glioma Details
PHP-1003 PHP-1003; PHP1003 Phase 1 Clinical Suzhou Pulekang Pharmaceutical Technology Co Ltd Graves Ophthalmopathy Details
Lonigutamab VB-421 Phase 2 Clinical Pierre Fabre Group Graves Ophthalmopathy Details
Insulin-Like Growth Factor 1 (Wright State Physicians) Phase 1 Clinical Wright State Physicians Nasolabial fold wrinkles; Burns; Sunburn Details
Humanized IgG1κ monoclonal antibody(Viridian) ZB-001; AVE-1642; VRDN-001 Phase 3 Clinical Viridian Therapeutics Inc Solid tumours; Graves Ophthalmopathy; Multiple Myeloma; Breast Neoplasms Details
Ganitumab AMG-479 Phase 3 Clinical Amgen Inc Prostatic Neoplasms; Neuroectodermal Tumors, Primitive, Peripheral; Gastrointestinal Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Rhabdomyosarcoma, Alveolar; Lymphoma; Lung Neoplasms; Neuroectodermal Tumors, Primitive; Colorectal Neoplasms; Sarcoma, Ewing; Breast Neoplasms; Sarcoma; Solid tumours; Pancreatic Neoplasms; Colonic Neoplasms; Small Cell Lung Carcinoma; Neoplasms; Rhabdomyosarcoma, Embryonal; Rectal Neoplasms; Carcinoid Tumor; Ovarian Neoplasms; Rhabdomyosarcoma; Bone metastases; Intestinal Neoplasms Details
VRDN-002 VRDN-002 Phase 1 Clinical Viridian Therapeutics Inc Graves Ophthalmopathy Details
Mecasermin Rinfabate OHB-607; SHP-607; HGT-ROP-001; rhIGF-I/rhIGFBP-3; TAK-607 Phase 2 Clinical Insmed Noonan Syndrome; Failure to Thrive; Cerebral Intraventricular Hemorrhage; Bronchopulmonary Dysplasia; Myotonic Dystrophy; Retinopathy of Prematurity; Muscular Dystrophies; Laron Syndrome Details
CT-102 CT-102 Phase 2 Clinical Hangzhou Tianlong Pharmaceutical Co Ltd, Institute Of Radiation And Radiation Medicine, Chinese Academy Of Military Medical Sciences Liver Neoplasms; Carcinoma, Hepatocellular Details
Conteltinib CT-707; SY-707 Phase 3 Clinical Shouyao Holding (Beijing) Co Ltd, Beijing Centaurus Biopharma Co Ltd Pancreatic Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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