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Brief Information

Name:V-set domain-containing T-cell activation inhibitor 1
Target Synonym:V-Set Domain-Containing T-Cell Activation Inhibitor 1,Immune costimulatory protein B7-H4,B7h.5,B7 homolog 4,T-cell costimulatory molecule B7x,V-Set Domain Containing T Cell Activation Inhibitor 1,B7X,B7 Family Member, H4,T Cell Costimulatory Molecule B7x,B7S1,B7 Superfamily Member 1,VCTN1,PRO1291,FLJ22418,B7H4,B7-H4,Protein B7S1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:11
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

CHEK-ATP126-Cell-based assay

Expression analysis of human B7-H4 on HEK293/Human B7-H4 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human B7-H4 Stable Cell Line or negative control cell using PE-labeled anti-human B7-H4 antibody.

 B7-H4 SPR

Anti-B7-H4 antibody, Human IgG1 captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Canine B7-H4, His Tag (Cat. No. B74-C52H8) with an affinity constant of 8.59 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).


Immobilized Rat B7-H4, His Tag (Cat. No. B74-R52H9) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Human B7-H4 Antibody, Human IgG1 with a linear range of 0.1-8 ng/mL (QC tested).

Customer Reviews

Synonym Name



V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
GEN-1047 GEN-1047 Phase 2 Clinical Genmab A/S Carcinoma, Non-Small-Cell Lung Details
AZD-8205 AZD-8205 Phase 2 Clinical Astrazeneca Plc Ovarian Neoplasms; Biliary Tract Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Cholangiocarcinoma; Breast Neoplasms; Endometrial Neoplasms; Neoplasm Metastasis Details
HS-20089 HS-20089 Phase 2 Clinical Shanghai Hansoh Biomedical Co Ltd Ovarian Neoplasms; Solid tumours; Peritoneal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms Details
Alsevalimab FPA-150 Phase 1 Clinical Five Prime Therapeutics Inc Ovarian Neoplasms; Solid tumours; Breast Neoplasms; Endometrial Neoplasms Details
ABL-103 ABL-103 Phase 1 Clinical Abl Bio Inc, Handok Inc Solid tumours Details
GSK-5733584 GSK5733584; GSK-5733584 Phase 1 Clinical Glaxosmithkline Plc Genital Neoplasms, Female Details
DB-1312 BG-C9074; DB-1312 Phase 1 Clinical Duality Biologics Co Ltd Solid tumours Details
XKH-002 XKH-002; XKH002 Phase 1 Clinical Beijing Kanova Biomedical Technology Co Ltd, Suzhou Kanova Biopharmaceutical Co Ltd Solid tumours; Neoplasms Details
SGN-B7H4V SGN-B7H4V; SGN-B-7H-4V; SGNB-7H4V; SGNB-7H-4V Phase 1 Clinical Seagen Inc Ovarian Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Adenoid Cystic; Breast Neoplasms; Cholangiocarcinoma; Peritoneal Neoplasms; Endometrial Neoplasms; Gallbladder Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung Details
XMT-1660 XMT-1660 Phase 1 Clinical Mersana Therapeutics Inc Ovarian Neoplasms; Abdominal Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Carcinoma, Adenoid Cystic; Breast Neoplasms; Fallopian Tube Neoplasms; Endometrial Neoplasms Details
HBM-7008 HBM7008; HBM-7008; R-7008 Phase 1 Clinical Harbour Biomed Solid tumours Details

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