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B7-H4

B7-H4 Part of Bioactivity data

B74-H82E2-ELISA
Biotinylated Human B7-H4, Avitag,His Tag (recommended for biopanning)Biotinylated Human B7-H4, Avitag,His Tag (recommended for biopanning) (Cat. No. B74-H82E2) ELISA bioactivity

Immobilized Anti-Human B7-H4 MAb, Human IgG1 at 2 μg/mL (100 μL/well) can bind Biotinylated Human B7-H4, Avitag,His Tag (recommended for biopanning) (Cat. No. B74-H82E2) with a linear range of 3-48 ng/mL (QC tested).

B74-H5256-ELISA
Human B7-H4, Fc Tag, low endotoxinHuman B7-H4, Fc Tag, low endotoxin (Cat. No. B74-H5256) ELISA bioactivity

Immobilized Human B7-H4, Fc Tag, low endotoxin (Cat. No. B74-H5256) at 0.5 μg/mL (100 μL/well) can bind Anti-B7-H4 MAb (Human IgG1) with a linear range of 0.2-8 ng/mL (QC tested).

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B7-H4 Molecule Synonym Name

B7-H4,VTCN1,B7S1,B7h.5

B7-H4 Molecule Background

V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

B7-H4 References

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