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Your Position: Home > B7-H4

B7-H4

Brief Information

Name:V-set domain-containing T-cell activation inhibitor 1
Target Synonym:V-Set Domain-Containing T-Cell Activation Inhibitor 1,Immune costimulatory protein B7-H4,B7h.5,B7 homolog 4,T-cell costimulatory molecule B7x,V-Set Domain Containing T Cell Activation Inhibitor 1,B7X,B7 Family Member, H4,T Cell Costimulatory Molecule B7x,B7S1,B7 Superfamily Member 1,VCTN1,PRO1291,FLJ22418,B7H4,B7-H4,Protein B7S1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CHEK-ATP126 Human HEK293/Human B7-H4 Stable Cell Line
B74-M52H7 Mouse Azide-labeled Mouse B7-H4 Protein, His Tag (MALS verified)
B74-M52H7-structure
B74-M52H7-sds
B74-C52H8 Canine Canine B7-H4 Protein, His Tag (MALS verified)
B74-C52H8-structure
B74-C52H8-sds
B74-R52H9 Rat Rat B7-H4 Protein, His Tag
B74-R52H9-structure
B74-R52H9-sds
B74-C52H9 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque B7-H4 Protein, His Tag
B74-C52H9-structure
B74-C52H9-sds
B74-M52H9 Mouse Mouse B7-H4 Protein, His Tag
B74-M52H9-structure
B74-M52H9-sds
B74-H5256 Human Human B7-H4 Protein, Fc Tag, low endotoxin
B74-H5256-structure
B74-H5256-sds
B74-H82E2 Human Biotinylated Human B7-H4 Protein, Avitag™,His Tag (recommended for biopanning)
B74-H82E2-structure
B74-H82E2-sds
B74-H8222 Human Biotinylated Human B7-H4 Protein, His Tag, ultra sensitivity (primary amine labeling)
B74-H8222-structure
B74-H8222-sds
B74-H5222 Human Human B7-H4 Protein, His Tag (MALS verified)
B74-H5222-structure
B74-H5222-sds
ACRO Quality

Part of Bioactivity data

CHEK-ATP126-Cell-based assay
B7-H4 FACS

Expression analysis of human B7-H4 on HEK293/Human B7-H4 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human B7-H4 Stable Cell Line or negative control cell using PE-labeled anti-human B7-H4 antibody.

Protocol
B74-C52H8-SPR
B7-H4 SPR

Anti-B7-H4 antibody, Human IgG1 captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Canine B7-H4, His Tag (Cat. No. B74-C52H8) with an affinity constant of 8.59 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
B74-R52H9-ELISA
B7-H4 ELISA

Immobilized Rat B7-H4, His Tag (Cat. No. B74-R52H9) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Human B7-H4 Antibody, Human IgG1 with a linear range of 0.1-8 ng/mL (QC tested).

Protocol

Customer Reviews

Synonym Name

B7-H4,VTCN1,B7S1,B7h.5

Background

V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Alsevalimab FPA-150 Phase 1 Clinical Five Prime Therapeutics Inc Solid tumours; Ovarian Neoplasms; Neoplasms; Breast Neoplasms; Endometrial Neoplasms Details
AZD-8205 AZD-8205 Phase 2 Clinical Astrazeneca Plc Ovarian Neoplasms; Cholangiocarcinoma; Breast Neoplasms; Endometrial Neoplasms Details
GEN-1047 GEN-1047 Phase 2 Clinical Genmab A/S Ovarian Neoplasms; Breast Neoplasms; Uterine Neoplasms; Carcinoma, Non-Small-Cell Lung Details
NC-762 NC-762 Phase 2 Clinical Nextcure Inc Ovarian Neoplasms; Solid tumours; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
HS-20089 HS-20089 Phase 1 Clinical Shanghai Hansoh Biomedical Co Ltd Solid tumours Details
PF-07260437(Pfizer) PF-07260437 Phase 1 Clinical Pfizer Inc Ovarian Neoplasms; Breast Neoplasms; Endometrial Neoplasms Details
XMT-1660 XMT-1660 Phase 1 Clinical Mersana Therapeutics Inc Ovarian Neoplasms; Abdominal Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Breast Neoplasms; Fallopian Tube Neoplasms; Endometrial Neoplasms Details
SGN-B7H4V SGN-B-7H-4V; SGNB-7H4V; SGNB-7H-4V; SGN-B7H4V Phase 1 Clinical Seagen Inc Ovarian Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Adenoid Cystic; Cholangiocarcinoma; Breast Neoplasms; Peritoneal Neoplasms; Endometrial Neoplasms; Gallbladder Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung Details
XKH-002 XKH-002; XKH002 Phase 1 Clinical Beijing Kanova Biomedical Technology Co Ltd, Suzhou Kanova Biomedical Technology Co Ltd Neoplasms Details
HBM-7008 HBM7008; HBM-7008; R-7008 Phase 1 Clinical Harbour Biomed Solid tumours Details

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