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IL-12B

Brief Information

Name:Interleukin-12 subunit beta
Target Synonym:IL-12B,NK cell stimulatory factor chain 2,IL12B,Interleukin 12B,Interleukin 12B (Natural Killer Cell Stimulatory Factor 2, Cytotoxic Lymphocyte Maturation Factor 2, P40),Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit,Interleukin-12 Beta Chain,Interleukin 12, P40,IL12, Subunit P40,CLMF P40,NKSF2,Cytotoxic Lymphocyte Maturation Factor 2, P40,Interleukin-12 Subunit Beta,CLMF2,IMD28,IMD29,CLMF,NKSF,Interleukin-12 Subunit p40,Natural Killer Cell Stimulatory Factor, 40 KD Subunit,IL-12 Subunit
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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Part of Bioactivity data

NK2-H52H7-BLI
 IL-12B BLI

Loaded Human IL-12 R beta 1, Fc Tag (Cat. No. ILB-H5255) on Protein A Biosensor, can bind Human IL-12B, His Tag (Cat. No. NK2-H52H7) with an affinity constant of 3.78 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

NK2-H52H7-BLI
 IL-12B BLI

Loaded Anti-IL23A & IL12B MAb (P40 domain) on Protein A Biosensor, can bind Human IL-12B, His Tag (Cat. No. NK2-H52H7) with an affinity constant of 0.279 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

IL12B,CLMF,CLMF2,NKSF,NKSF2,p40

Background

Interleukin-12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF) , is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.Interleukin-12 subunit beta (IL12B) also known as NKSF2, CLMF2 and P40. Interleukin-12 subunit beta has been shown to interact with IL23. A large excess of monomeric IL12B is also secreted by the cells producing IL12, and exhibits no demonstrable biological activity. Overexpression of IL12B gene has been shown to be associated with the pathogenesis of multiple sclerosis. In addition, studies have revealed that the promoter polymorphism of this gene is implicated in the severity of atopic and non-atopic asthma in children.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Ustekinumab CNTO-1275; C-340; AVT-04 Approved Janssen Global Services Llc 喜达诺, Stelara United States Plaque psoriasis Janssen Biotech Inc 2009-09-25 Multiple Sclerosis; Dermatitis, Atopic; Plaque psoriasis; Crohn Disease; Common Variable Immunodeficiency; Uveitis; Hidradenitis Suppurativa; Arthritis, Psoriatic; Colitis, Ulcerative; Lupus Erythematosus, Systemic; Takayasu Arteritis; Psoriasis; Liver Cirrhosis, Biliary; Arthritis, Juvenile; Ichthyosis; Sjogren's Syndrome; Pouchitis; Inflammatory Bowel Diseases; Type I Leukocyte Adhesion Defect; Dermatomyositis; Non-radiographic axial spondyloarthritis; Polymyositis; Diabetes Mellitus, Type 1 Details
Ustekinumab biosimilar(Amgen) ABP-654 Approved Amgen Inc Wezlana, WEZLANA United States Arthritis, Psoriatic; Plaque psoriasis; Colitis, Ulcerative; Crohn Disease Amgen Inc 2023-10-31 Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Plaque psoriasis; Crohn Disease Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SAR-441000 SAR441000; SAR-441000; BNT-131 Phase 1 Clinical Biontech Se, Sanofi Neoplasm Metastasis Details
Ustekinumab biosimilar (Samsung Bioepis) SB-17; SB17 Phase 3 Clinical Samsung Bioepis Co Ltd Psoriasis; Plaque psoriasis Details

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