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IL-12B Molecule Information

Name:Interleukin-12 subunit beta
Target Synonym:NKSF2;IL-12B;Interleukin-12 subunit beta;CLMF p40;IL-12 subunit p40;IL12B;NK cell stimulatory factor chain 2;Cytotoxic lymphocyte maturation factor 40 kDa subunit
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase ?

IL-12B Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
NK2-H5258 Human Human IL-12B / NKSF2 / p40 Protein, Fc Tag
NK2-H52H7 Human Human IL-12B / NKSF2 / p40 Protein, His Tag

IL-12B Part of Bioactivity data


Loaded Human IL-12 R beta 1, Fc Tag (Cat. No. ILB-H5255) on Protein A Biosensor, can bind Human IL-12B, His Tag (Cat. No. NK2-H52H7) with an affinity constant of 3.78 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).


Loaded Anti-IL23A & IL12B MAb (P40 domain) on Protein A Biosensor, can bind Human IL-12B, His Tag (Cat. No. NK2-H52H7) with an affinity constant of 0.279 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).


IL-12B Molecule Background

Interleukin-12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF) , is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels. Interleukin-12 subunit beta (IL12B) also known as NKSF2, CLMF2 and P40. Interleukin-12 subunit beta has been shown to interact with IL23. A large excess of monomeric IL12B is also secreted by the cells producing IL12, and exhibits no demonstrable biological activity. Overexpression of IL12B gene has been shown to be associated with the pathogenesis of multiple sclerosis. In addition, studies have revealed that the promoter polymorphism of this gene is implicated in the severity of atopic and non-atopic asthma in children.

IL-12B References

IL-12B Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Esonarimod KE-298 Phase Ⅲ Taisho Pharmaceutical Rheumatoid arthritis (RA) Details
HP-228 HP-228; ILP-228 Phase Ⅱ Sygnis Obesity, Type 2 diabetes, Postoperative pain, Inflammation Details
Y-25510 Y-25510 Phase Ⅰ Mitsubishi Tanabe Pharma Leucopenia, Thrombocytopenia Details

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