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Brief Information

Name:V-domain Ig suppressor of T-cell activation
Target Synonym:Dies1,VSIR,V-Set Domain-Containing Immunoregulatory Receptor,DD1alpha,B7-H5,PD-1H,B7H5,GI24,Stress-induced secreted protein-1,PP2135,SISP1,UNQ730/PRO1412,V-type immunoglobulin domain-containing suppressor of T-cell activation,V-Set Immunoregulatory Receptor,V-Domain Ig Suppressor Of T Cell Activation,PDCD1 Homolog,C10orf54,Sisp-1,VISTA,Chromosome 10 Open Reading Frame 54,Stress Induced Secreted Protein 1,Platelet Receptor Gi24,Death Domain1alpha
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

 B7-H5 SPR

Human B7-H5 Protein, Mouse IgG2a Fc Tag (Cat. No. B75-H5258) Captured on CM5 chip via anti-mouse antibodies surface can bind Human VSIG3, Fc Tag (Cat. No. VS3-H5258) with an affinity constant of 8.87 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

 B7-H5 SPR

Human PSGL-1, His Tag (Cat. No. PS1-H52H9) immobilized on CM5 Chip can bind Human B7-H5, Fc Tag (Cat. No. B75-H5259) with an affinity constant of 0.213 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name



Platelet receptor Gi24, also known as B7-H5 and stress-induced secreted protein-1 (Sisp-1), is a protein that in humans is encoded by the C10orf54 gene, which contains 1 Ig-like (immunoglobulin-like) domain. As for C10orf54 gene, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state on ESCs. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SNS-101 (Sensei-Biotherapeutics) Phase 2 Clinical Sensei Biotherapeutics, Inc Solid tumours Details
KVA-12123 KVA-12123; KVA-12.1 Phase 2 Clinical GigaGen Inc Neoplasms; Melanoma; Lung Neoplasms; Thyroid Neoplasms; Uterine Neoplasms; Colorectal Neoplasms; Sarcoma; Breast Neoplasms; Prostatic Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma; Solid tumours; Kidney Neoplasms; Head and Neck Neoplasms Details
Onvatilimab CI-8993; JNJ-61610588 Phase 1 Clinical Johnson & Johnson Innovative Medicine, Immunext Inc Solid tumours; Neoplasms Details
HMBD-002 HMBD-002 Phase 1 Clinical Hummingbird Bioscience Solid tumours; Triple Negative Breast Neoplasms; Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
PMC-309 PMC-309 Phase 1 Clinical Pharmabcine Solid tumours; Neoplasms Details
CA-170 CA-170; AUPM-170 Phase 1 Clinical Aurigene Solid tumours Details

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