Login Register
icon_bulk_orderBulk order Acrobiosystems for English
0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > IL-15

IL-15

Brief Information

Name:Interleukin-15
Target Synonym:IL-15,Interleukin-15,IL15,Interleukin 15,MGC9721
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase 2 Clinical

Product ListCompare or Buy

Part of Bioactivity data

GMP-L15H13-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

GMP Human IL-15 (Cat. No. GMP-L15H13) stimulates proliferation of CTLL-2 cells. The EC50 for this effect is 1.004 ng/mL, corresponding to a specific activity of > 0.8ⅹ10^7 IU/mg, which is calibrated against human IL- 15 WHO International Standard (NIBSC code: 95/554) (QC tested).

IL5-M82F3-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Biotinylated Mouse IL-15, Fc,Avitag (Cat. No. IL5-M82F3) stimulates proliferation of CTLL-2 cells. The ED50 for this effect is 0.531-1.999 μg/mL (Routinely tested).

IL5-H4117-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-2 R beta, Fc Tag (SPR verified) (Cat. No. ILB-H5253) captured on CM5 chip via anti-human IgG Fc antibody, can bind Human IL-15, Tag Free (Cat. No. IL5-H4117) with an affinity constant of 9.5 nM as determined in a SPR assay (Biacore T200) (QC tested).

IL5-H4117-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-2 R beta, Fc Tag (SPR verified) (Cat. No. ILB-H5253) on Protein A Biosensor, can bind Human IL-15, Tag Free (Cat. No. IL5-H4117) with an affinity constant of 10.2 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

IL-15,Interleukin-15,MGC9721

Background

Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CALY-002 Phase 1 Clinical Calypso Biotech Bv Celiac Disease; Eosinophilic Esophagitis Details
CAR-5/IL-15-transduced CB-NK cell therapy Phase 2 Clinical The University Of Texas MD Anderson Cancer Center Hematologic Neoplasms Details
Ordesekimab AMG-714; HuMab-IL15; PRV-015 Phase 2 Clinical Genmab, Provention Bio, Amgen Inc Arthritis, Rheumatoid; Celiac Disease; Psoriasis Details
XmAb24306 XmAb-24306; RG-6323; RO-7310729; XmAb-306 Phase 1 Clinical Genentech Inc, Xencor Solid tumours Details
FT-536 FT-536 Phase 1 Clinical Fate Therapeutics Inc Solid tumours Details
Recombinant Human IL12/15-PDL1B Herpes Simplex Type I Oncolytic Virus(CNBG) VG-161 Phase 2 Clinical China Bio Fu Nuojian Biotechnology (Shanghai) Co Ltd Liver Neoplasms; Solid tumours; Biliary Tract Neoplasms; Cholangiocarcinoma; Carcinoma, Hepatocellular Details
RTX-240 RTX-240 Phase 2 Clinical Rubius Therapeutics Leukemia, Promyelocytic, Acute Details
Heterodimeric interleukin 15(Novartis Pharma) NIZ-985 Phase 1 Clinical Novartis Pharma Ag Solid tumours; Lymphoma; Melanoma Details
SAR-441000 SAR441000; SAR-441000; BNT-131 Phase 1 Clinical Biontech Se, Sanofi Neoplasm Metastasis Details
BNZ-2 BNZ-2 Phase 1 Clinical Bioniz Celiac Disease Details

This web search service is supported by Google Inc.

totop
Call us
Call us
North America: +1 800-810-0816 (Toll Free)
Asia & Pacific: +86 400-682-2521
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA

Leave a message