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Your Position: Home > IL-15

IL-15

Brief Information

Name:Interleukin-15
Target Synonym:IL-15,Interleukin-15,IL15,Interleukin 15,MGC9721
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase 2 Clinical

Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
CRS-A009 Human Human Interleukin-15(IL-15) ELISA Kit
GMP-L15H13 Human GMP Human IL-15 DMF Filed
GMP-L15H13-structure
GMP-L15H13-sds
IL5-H82E3 Human Biotinylated Human IL-15 Protein, His,Avitag™
IL5-H82E3-structure
IL5-H82E3-sds
IL5-C52H4 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque IL-15 Protein, His Tag
IL5-C52H4-structure
IL5-C52H4-sds
IL5-H52H8 Human Human IL-15 Protein, His Tag (MALS verified)
IL5-H52H8-structure
IL5-H52H8-sds
IL5-M5255 Mouse Mouse IL-15 Protein, Fc Tag
IL5-M5255-structure
IL5-M5255-sds
IL5-H82F3 Human Biotinylated Human IL-15 Protein, Fc,Avitag™ (MALS verified)
IL5-H82F3-structure
IL5-H82F3-sds
IL5-M82F3 Mouse Biotinylated Mouse IL-15 Protein, Fc,Avitag™
IL5-M82F3-structure
IL5-M82F3-sds
IL5-H4117 Human Human IL-15 Protein, premium grade
IL5-H4117-structure
IL5-H4117-sds

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Part of Bioactivity data

GMP-L15H13-Cell-based assay
 IL-15 CELL

GMP Human IL-15 (Cat. No. GMP-L15H13) stimulates proliferation of CTLL-2 cells. The specific activity of GMP Human IL-15 is > 0.8ⅹ10^7 IU/mg, which is calibrated against human IL- 15 WHO International Standard (NIBSC code: 95/554) (QC tested).

IL5-M82F3-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Biotinylated Mouse IL-15, Fc,Avitag (Cat. No. IL5-M82F3) stimulates proliferation of CTLL-2 cells. The ED50 for this effect is 0.531-1.999 μg/mL (Routinely tested).

IL5-H4117-SPR
 IL-15 SPR

Human IL-2 R beta, Fc Tag (Cat. No. ILB-H5253) captured on CM5 chip via anti-human IgG Fc antibody, can bind Human IL-15, premium grade (Cat. No. IL5-H4117) with an affinity constant of 9.5 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

IL5-H4117-BLI
 IL-15 BLI

Loaded Human IL-2 R beta, Fc Tag (Cat. No. ILB-H5253) on Protein A Biosensor, can bind Human IL-15, premium grade (Cat. No. IL5-H4117) with an affinity constant of 10.2 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Customer Reviews

Synonym Name

IL-15,Interleukin-15,MGC9721

Background

Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
VG-201 VG-201 Phase 1 Clinical ViroGin Biotech Ltd Esophageal Neoplasms; Stomach Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Recombinant Human IL12/15-PDL1B Herpes Simplex Type I Oncolytic Virus(CNBG) VG-161 Phase 2 Clinical Liver Neoplasms; Solid tumours; Biliary Tract Neoplasms; Esophageal Neoplasms; Neoplasms Details
CALY-002 Phase 1 Clinical Calypso Biotech Bv Eosinophilic Esophagitis; Celiac Disease Details
Heterodimeric interleukin 15(Novartis Pharma) NIZ-985 Novartis Pharma Ag Details
RTX-240 RTX-240 Rubius Therapeutics Details
Ordesekimab HuMab-IL15; AMG-714; PRV-015 Provention Bio, Genmab, Amgen Inc Details
SAR-441000 SAR441000; SAR-441000; BNT-131 Biontech Se, Sanofi Details
CAR-5/IL-15-transduced CB-NK cell therapy Phase 2 Clinical MD Anderson Cancer Center Hematologic Neoplasms Details
XmAb24306 XmAb-24306; RG-6323; RO-7310729; XmAb-306 Phase 1 Clinical Genentech Inc, Xencor Solid tumours; Neoplasms; Multiple Myeloma Details
CYTO-102 CYTO-NK-102; CYTO-102 Phase 1 Clinical CytoImmune Therapeutics Inc Carcinoma, Non-Small-Cell Lung Details
HCW-9218 HCW-9218 Phase 2 Clinical HCW Biologics Inc Solid tumours; Pancreatic Neoplasms; Pulmonary Fibrosis Details

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