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IL-15

Brief Information

Name:Interleukin-15
Target Synonym:IL-15,Interleukin-15,IL15,Interleukin 15,MGC9721
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

IL5-M82F3-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Biotinylated Mouse IL-15, Fc,Avitag (Cat. No. IL5-M82F3) stimulates proliferation of CTLL-2 cells. The ED50 for this effect is 0.531-1.999 μg/mL (Routinely tested).

IL5-H4117-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL-15, Tag Free (Cat. No. IL5-H4117) stimulates proliferation of CTLL-2 cells. The ED50 for this effect is 0.097-0.19 ng/mL (Routinely tested).

IL5-H4117-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-2 R beta, Fc Tag (SPR verified) (Cat. No. ILB-H5253) captured on CM5 chip via anti-human IgG Fc antibody, can bind Human IL-15, Tag Free (Cat. No. IL5-H4117) with an affinity constant of 9.5 nM as determined in a SPR assay (Biacore T200) (QC tested).

IL5-H4117-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-2 R beta, Fc Tag (SPR verified) (Cat. No. ILB-H5253) on Protein A Biosensor, can bind Human IL-15, Tag Free (Cat. No. IL5-H4117) with an affinity constant of 10.2 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

IL-15,Interleukin-15,MGC9721

Background

Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
BJ-001 BJ-001 Phase 1 Clinical Boji Biomedical Technology (Hangzhou) Co Ltd Communicable Diseases; Neoplasms Details
Recombinant human interleukin 15(Beijing Kawin) Phase 1 Clinical Beijing Kawin Technology Share-Holding Co Ltd Solid tumours Details
OXS-3550 OXS-3550-TriKE; GTB-3550; OXS-3550; OXIS-3550; 161533-TriKE; 161533 TriKE Phase 2 Clinical University Of Minnesota, Oxis Biotech Mastocytosis, Systemic; Myelodysplastic Syndromes; Leukemia, Mast-Cell; Leukemia, Myeloid, Acute Details
XmAb24306 XmAb-24306; RG-6323; RO-7310729 Phase 1 Clinical Xencor Solid tumours Details
CALY-002 Phase 1 Clinical Calypso Biotech Bv Celiac Disease; Eosinophilic Esophagitis Details
AMG-714 AMG-714; PRV-015; HuMab-IL15 Phase 2 Clinical Genmab Arthritis, Rheumatoid; Psoriasis; Celiac Disease Details

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