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IL-15

IL-15 Molecule Information

Name:Interleukin-15
Target Synonym:Interleukin-15;IL15;IL-15
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase ?

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IL-15 Part of Bioactivity data

IL5-M82F3-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Biotinylated Mouse IL-15, Fc,Avitag (Cat. No. IL5-M82F3) stimulates proliferation of CTLL-2 cells. The ED50 for this effect is 0.531-1.999 μg/mL (Routinely tested).

IL5-H4117-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL-15, Tag Free (Cat. No. IL5-H4117) stimulates proliferation of CTLL-2 cells. The ED50 for this effect is 0.097-0.19 ng/mL (Routinely tested).

IL5-H4117-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-2 R beta, Fc Tag (SPR verified) (Cat. No. ILB-H5253) captured on CM5 chip via anti-human IgG Fc antibody, can bind Human IL-15, Tag Free (Cat. No. IL5-H4117) with an affinity constant of 9.5 nM as determined in a SPR assay (Biacore T200) (QC tested).

IL5-H4117-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-2 R beta, Fc Tag (SPR verified) (Cat. No. ILB-H5253) on Protein A Biosensor, can bind Human IL-15, Tag Free (Cat. No. IL5-H4117) with an affinity constant of 10.2 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

IL-15 Molecule Synonym Name

IL-15,Interleukin-15,MGC9721

IL-15 Molecule Background

Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.

IL-15 References

IL-15 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
OXS-C3550 OXS-3350; OXS-C3550 Preclinical University of Minnesota, GT Biopharma Acute myeloid Leukemia (AML) Details
Humanized mik-beta-1 mAb (National Cancer Institute) Hu-mik-beta-1 Phase Ⅰ National Cancer Institute Celiac disease Details
BJ-001 BJ-001 Phase Ⅰ BJ Bioscience Solid tumours, Infectious disease Details
SHR-1501 SHR-1501,SHR1501 Phase Ⅰ Jiangsu Hengrui Medicine Malignancies Details
Anti-interleukin-15-vaccine (CIGB) CIGB-50 Phase Ⅰ Center for Genetic Engineering and Biotechnology, Heber Biotech Rheumatoid arthritis (RA) Details
AMG-714 AMG-714; HuMab-IL15; PRV-015 Phase Ⅱ Genmab, Amgen, Celimmune, Provention Bio Celiac disease Details
XmAb24306 XmAb-24306,XmAb24306 Phase Ⅰ Xencor, Roche Solid tumors Details

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