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Your Position: Home > IL-15


Brief Information

Target Synonym:IL-15,Interleukin-15,IL15,Interleukin 15,MGC9721
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

IL5-H5257-Cell-based assay

Human IL-15 Protein, Fc Tag, premium grade (Cat. No. IL5-H5257) stimulates proliferation of CTLL-2 cells. The typically EC50 for this effect is 2.483 ng/mL(QC tested).

IL5-H5215-Cell-based assay

Human IL-15, premium grade (Cat. No. IL5-H5215) stimulates proliferation of CTLL-2 cells. The typically EC50 for this effect is 0.6068 ng/mL, corresponding to a specific activity of > 0.8ⅹ10^7 IU/mg, which is calibrated against human IL- 15 WHO International Standard (NIBSC code: 95/554) (QC tested).

 IL-15 SPR

Biotinylated Human IL-15 R alpha, Fc,Avitag (Cat. No. ILA-H82F4) immobilized on CM5 Chip can bind Human IL-15 Protein, Fc Tag, premium grade (Cat. No. IL5-H5257) with an affinity constant of 27.7 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).

 IL-15 SPR

Human IL-2 R beta, Fc Tag (Cat. No. ILB-H5253) captured on CM5 chip via anti-human IgG Fc antibody, can bind Human IL-15, premium grade (Cat. No. IL5-H4117) with an affinity constant of 9.5 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name



Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
VG-201 VG-201 Phase 1 Clinical ViroGin Biotech Ltd Esophageal Neoplasms; Stomach Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
SAR-441000 SAR441000; SAR-441000; BNT-131 Phase 1 Clinical Biontech Se, Sanofi Neoplasm Metastasis Details
CAR-5/IL-15-transduced CB-NK cell therapy Phase 2 Clinical MD Anderson Cancer Center Hematologic Neoplasms Details
HCW-9218 HCW-9218 Phase 2 Clinical HCW Biologics Inc Solid tumours; Pancreatic Neoplasms; Pulmonary Fibrosis Details
Heterodimeric interleukin 15(Novartis Pharma) NIZ-985 Phase 1 Clinical Novartis Pharma Ag Solid tumours; Lymphoma Details
Ordesekimab HuMab-IL15; AMG-714; PRV-015 Phase 2 Clinical Provention Bio Inc, Genmab A/S, Amgen Inc Arthritis, Rheumatoid; Psoriasis; Celiac Disease; Vitiligo Details
CALY-002 Phase 1 Clinical Calypso Biotech Bv Celiac Disease; Eosinophilic Esophagitis Details
CYTO-102 CYTO-NK-102; CYTO-102; COH06 Phase 1 Clinical CytoImmune Therapeutics Inc Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
XmAb24306 XmAb-24306; RG-6323; RO-7310729; XmAb-306 Phase 1 Clinical Genentech Inc, Xencor Inc Solid tumours; Neoplasms; Multiple Myeloma Details
EQ101 EQ101 Phase 2 Clinical Equillium Inc Alopecia; Alopecia Areata Details
Recombinant Human IL12/15-PDL1B Herpes Simplex Type I Oncolytic Virus(CNBG) VG-161 Phase 2 Clinical Cnbg-Virogin Biotech (Shanghai) Ltd Liver Neoplasms; Solid tumours; Biliary Tract Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms; Neoplasms; Cholangiocarcinoma; Carcinoma, Hepatocellular Details
SIM-0237 SIM-0237 Phase 1 Clinical Simcere Pharmaceutical Group Ltd Solid tumours Details

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