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IL-17 RA

IL-17 RA Molecule Information

Name:Interleukin-17 receptor A
Target Synonym:IL-17 receptor A,IL17R,IL17RA,Interleukin 17 Receptor A,IL-17RA,Interleukin 17 Receptor,CD217 Antigen,HIL-17R,CANDF5,CD217,IMD51,CDw217,Interleukin-17 receptor A
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

IL-17 RA Protein Product ListCompare or Buy

IL-17 RA Part of Bioactivity data

ILA-H82F1-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human IL-17 RA, Fc,Avitag (Cat. No. ILA-H82F1) on SA Biosensor, can bind Human IL17A, Tag Free (Cat. No. ILA-H5118) with an affinity constant of 1.29 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

ILA-H5257-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-17 RA, Fc Tag (Cat. No. ILA-H5257) on Protein A Biosensor, can bind Human IL17A, Tag Free (Cat. No. ILA-H5118) with an affinity constant of 0.21 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

IL-17 RA Molecule Synonym Name

CD217,CDw217,IL-17RA,IL17R,CANDF5,hIL-17R

IL-17 RA Molecule Background

Interleukin 17 receptor A (IL17RA) is also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes, belong to ubiquitous type I membrane glycoprotein, and binds with low affinity to interleukin 17A (IL17A). IL 17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested . IL 17RA associates with IL 17RC to form a signaling receptor complex for IL 17 and IL 17F . Ligand and IL 17RA ligation promotes T cell activation and the production of IL - 6, G-CSF, SCF, and multiple pro-inflammatory chemokines. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5).

IL-17 RA References

IL-17 RA Related Molecule

IL-17 RA Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Brodalumab IL-17R mAb; MEDI-6365; KHK-4827; AMG-827 Approved Amgen Inc Siliq, Lumicef, Kyntheum, 立美芙 Mainland China Plaque psoriasis s:11:"Kyowa Kirin"; 2016-07-04 Spondylitis, Ankylosing; Scleroderma, Systemic; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Asthma; Plaque psoriasis; Crohn Disease Details

IL-17 RA Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
XCUR-17 XCUR-17 Phase 1 Clinical Exicure Psoriasis Details
LY-3114062 LY3114062; LY-3114062 Phase 1 Clinical Eli Lilly And Company Arthritis Details

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