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Your Position: Home > IL-4 R alpha

IL-4 R alpha

IL-4 R alpha Molecule Information

Name:Interleukin-4 receptor subunit alpha
Target Synonym:IL-4R-alpha,Soluble IL-4 receptor subunit alpha,582J2.1,Soluble IL-4R-alpha,IL-4RA,IL4-BP,sIL4Ralpha/prot,CD124,Interleukin 4 Receptor,IL-4 Receptor Subunit Alpha,IL4RA,Interleukin-4 Receptor Subunit Alpha,Interleukin-4 Receptor Alpha Chain,IL4R Nirs Vari
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
ILR-H5253 Human Human IL-4 R alpha / CD124 Protein, Fc Tag
ILR-H5253-structure
ILR-H5253-sds
ILR-H5253-elisa_1
ILR-H82E9 Human Biotinylated Human IL-4 R alpha / CD124 Protein, Avitag™,His Tag
ILR-H82E9-structure
ILR-H82E9-sds
ILR-H82E9-elisa_1
ILR-M5252 Mouse Mouse IL-4 R alpha / CD124 Protein, Fc Tag
ILR-M5252-structure
ILR-M5252-sds
ILR-M5252-elisa_1
ILR-M52H1 Mouse Mouse IL-4 R alpha / CD124 Protein, His Tag
ILR-M52H1-structure
ILR-M52H1-sds
ILR-M52H1-elisa_1
ILR-C52H8 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque IL-4 R alpha / CD124 Protein, His Tag
ILR-C52H8-structure
ILR-C52H8-sds
ILR-C52H8-elisa_1
ILR-C5258 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque IL-4 R alpha / CD124 Protein, Fc Tag
ILR-C5258-structure
ILR-C5258-sds
ILR-C5258-elisa_1
ILR-H5221 Human Human IL-4 R alpha / CD124 Protein, His Tag
ILR-H5221-structure
ILR-H5221-sds
ILR-H5221-elisa_1

IL-4 R alpha Part of Bioactivity data

ILR-H82E9-ELISA
Biotinylated Human IL-4 R alpha, Avitag,His TagBiotinylated Human IL-4 R alpha, Avitag,His Tag (Cat. No. ILR-H82E9) ELISA bioactivity

Immobilized Human IL-4, Tag Free (Cat. No. IL4-H4218) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-4 R alpha, Avitag,His Tag (Cat. No. ILR-H82E9) with a linear range of 0.005-0.078 μg/mL (QC tested).

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ILR-H5253-ELISA
Human IL-4 R alpha, Fc TagHuman IL-4 R alpha, Fc Tag (Cat. No. ILR-H5253) ELISA bioactivity

Immobilized Human IL-4, Tag Free (Cat. No. IL4-H4218) at 5 μg/mL (100 μL/well)can bind Human IL-4 R alpha, Fc Tag (Cat. No. ILR-H5253) with a linear range of 1-20 ng/mL (QC tested).

Protocol

IL-4 R alpha Molecule Synonym Name

IL4R,CD124,IL4RA

IL-4 R alpha Molecule Background

IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4R¦Á (CD124)subunit and the 70 kDa common cytokine ¦Ãc chain (CD132). Interleukin

IL-4 R alpha Related Molecule

IL-4

IL-4 R alpha Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Dupilumab SAR-231893; REGN-668 Approved Sanofi, Regeneron Pharmaceuticals Inc Dupixent Mainland China Dermatitis, Atopic s:20:"Sanofi-Aventis Group"; 2017-03-28 Pemphigoid, Bullous; Hypersensitivity; Dermatitis, Atopic; Keratoconjunctivitis; Peanut Hypersensitivity; Hypersensitivity, Immediate; Pulmonary Disease, Chronic Obstructive; Sinusitis; Urticaria; Prurigo; Aspergillosis, Allergic Bronchopulmonary; Neurodermatitis; Asthma; Rhinitis, Allergic; Eosinophilic Esophagitis; Genetic Diseases, Inborn; Skin Diseases; Skin Diseases, Eczematous; Dermatitis; Chronic Urticaria Details

IL-4 R alpha Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AK120 (Akeso Biopharma) AK120 (Akeso Biopharma) Phase 1 Clinical Zhongshan Akeso Biopharma Co Ltd Dermatitis, Atopic Details
Recombinant anti-IL-4Rα humanized monoclonal antibody (Sansheng Guojian) 611 Phase 1 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd Dermatitis, Atopic Details
QX-005N QX-005N Phase 1 Clinical Jiangsu Quanxin Biomedical Co Ltd Dermatitis, Atopic Details
MG-K10 MG-K10; MG-010 Phase 1 Clinical Shanghai Mabgeek Biotechnology Co Ltd, Dragonboat Biopharmaceutical Asthma Details
Interleukin-4(38-37)-PE38KDEL MDNA-55; IL4-PE; NBI-3001; PRX-321 Phase 2 Clinical Neurocrine Biosciences, National Institute of Health, Islamabad Kidney Neoplasms; Glioblastoma; Central Nervous System Neoplasms; Brain Neoplasms; Breast Neoplasms; Glioma; Lung Neoplasms Details
SHR-1819 SHR-1819 Phase 1 Clinical Atridia Pty Ltd Asthma Details
CBP-201 CBP-201 Phase 2 Clinical Suzhou Conrad Biomedicine Co Ltd Nose Diseases; Asthma; Dermatitis, Atopic Details
PRS-060 PRS-060; AZD-1402 Phase 2 Clinical University Of Melbourne, Pieris Pharmaceuticals Asthma Details
Recombinant humannized monoclonal antibody (Conmed Biosciences) CM-310 Phase 2 Clinical Connaught Biomedical Technology (Chengdu) Co Ltd Nasal Polyps; Asthma; Sinusitis; Dermatitis, Atopic Details

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