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IL-7

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Cat. No. Species Product Description Structure Purity Feature
GMP-L07H24 Human GMP Human IL-7
GMP-L07H24-structure
GMP-L07H24-sds
IL7-H5253 Human Human IL-7 Protein, Fc Tag (MALS verified)
IL7-H5253-structure
IL7-H5253-sds
IL7-H4219 Human ActiveMax® Human IL-7 Protein, Tag Free, Ultra-low endotoxin (MALS verified)
IL7-H4219-structure
IL7-H4219-sds

Part of Bioactivity data

GMP-L07H24-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

GMP Human IL-7 (Cat. No. GMP-L07H24) stimulates proliferation of PHA-P-activated human peripheral blood mononuclear cell (PBMC). The EC50 for this effect is 3.821 ng/mL, corresponding to a specific activity of > 1.0 ⅹ10^8 IU/mg, which is calibrated against human IL-7 WHO International Standard (NIBSC code: 90/530) (QC tested).

IL7-H4219-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

ActiveMax Human IL-7, Tag Free (Cat. No. IL7-H4219) stimulates proliferation of PHA-P-activated human peripheral blood mononuclear cell (PBMC). The EC50 for this effect is 1.565 ng/mL, corresponding to a specific activity of > 1.0 ⅹ10^8 IU/mg, which is calibrated against human IL-7 WHO International Standard (NIBSC code: 90/530) (QC tested).

IL7-H4219-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-7 R alpha, Fc Tag (Cat. No. ILA-H5258) on Protein A Biosensor, can bind IL-7, Tag Free (Cat. No. IL7-H4219) with an affinity constant of 0.21 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

IL7-H5253-MALS-HPLC
Human IL-7, Fc Tag (Cat. No. ) MALS images

The purity of Human IL-7, Fc Tag (Cat. No. IL7-H5253) is more than 85% and the molecular weight of this protein is around 107-120 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human IL-7, Fc TagHuman IL-7, Fc Tag (Cat. No. IL7-H5253) ELISA bioactivity

Immobilized Human IL-7 R alpha, Mouse IgG2a Fc Tag (Cat. No. IL7-H5258) at 2 μg/mL (100 μL/well) can bind Human IL-7, Fc Tag (Cat. No. IL7-H5253) with a linear range of 0.3-5 ng/mL (QC tested).

Synonym Name

IL7,Interleukin-7

Background

Interleukin 7 is also known as IL7, IL-7, and is a hematopoietic growth factor secreted by stromal cells in the red marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, but is not produced by lymphocytes. IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells, It also stimulates proliferation of all cells in the lymphoid lineage (B cells, T cells and NK cells). It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis. IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL-7 binds to the IL-7 receptor, a heterodimer consisting of Interleukin-7 receptor alpha and common gamma chain receptor. Il-7 promotes hematological malignacies (acute lymphoblastic leukemia, T cell lymphoma). Elevated levels of IL-7 have also been detected in the plasma of HIV-infected patients. IL-7 as an immunotherapy agent has been examined in many pre-clinical animal studies and more recently in human clinical trials for various malignancies and during HIV infection. IL-7 could also be beneficial in improving immune recovery after allogenic stem cell transplant.

Clinical and Translational Updates

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