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Your Position: Home > IL-7 R alpha

IL-7 R alpha

Brief Information

Name:Interleukin-7 receptor subunit alpha
Target Synonym:Interleukin-7 receptor subunit alpha,Interleukin 7 Receptor Isoform H5-6,CDw127,IL-7R subunit alpha,IL-7RA,IL-7 receptor subunit alpha,CD127 Antigen,IL-7R-Alpha,Interleukin 7 Receptor Alpha Chain,CD127,IL7RA,ILRA,Interleukin-7 Receptor alpha Subunit
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase 2 Clinical

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Synonym Name

IL7Ra,CD127

Background

Interleukin-7 receptor subunit alpha (IL7Ra) is also known as CD antigen CD127, which belongs to the type I cytokine receptor family and type 4 subfamily. IL7Ra /CD127 contains 1 fibronectin type-III domain. IL7Ra /CD127 is expressed on various cell types, including naive and memory T cells and many others. IL7Ra /CD127 is receptor for interleukin-7 and also acts as a receptor for thymic stromal lymphopoietin (TSLP). The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Interleukin-7 (Revimmune SAS) rhIL-7; CYT-107; CYT-99-007 Phase 2 Clinical Cytheris Urinary Bladder Neoplasms; Catheter-Related Infections; Neuroectodermal Tumors, Primitive, Peripheral; Melanoma; T-Lymphocytopenia, Idiopathic CD4-Positive; Leukemia, Myeloid, Acute; Urologic Neoplasms; Ureteral Neoplasms; Hepatitis C; Lymphopenia; Urethral Neoplasms; Prostatic Neoplasms; Sarcoma; Neuroblastoma; Shock, Septic; Prostatic Neoplasms, Castration-Resistant; Carcinoma, Transitional Cell; Sepsis; Myeloproliferative Disorders; Coronavirus Disease 2019 (COVID-19); Mycobacterium Infections, Nontuberculous; Myelodysplastic Syndromes; Carcinoma, Renal Cell; Hepatitis B, Chronic; Rhabdoid Tumor; Leukemia, Myelogenous, Chronic; Kidney Neoplasms; HIV Infections Details
MDK-703 MDK-703 Phase 2 Clinical Medikine Inc Solid tumours Details
GSK-3888130-B GSK-3888130-B; GSK3888130B Phase 1 Clinical Glaxosmithkline Plc Multiple Sclerosis Details
PF-06342674 RN-168; PF-6342674; PF-06342674; ZB-168 Phase 1 Clinical Pfizer Inc Diabetes Mellitus, Type 1; Multiple Sclerosis Details
Efineptakin alfa NT-I7; GX-I7; TJ-107 Phase 2 Clinical Genexine Inc Pancreatic Neoplasms; Carcinoma, Non-Small-Cell Lung; Sarcoma, Kaposi; Melanoma; Leukoencephalopathy, Progressive Multifocal; Carcinoma, Squamous Cell; Lymphopenia; Colorectal Neoplasms; Breast Neoplasms; Urinary Bladder Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Triple Negative Breast Neoplasms; Papillomavirus Infections; Glioblastoma; Coronavirus Disease 2019 (COVID-19); Squamous Cell Carcinoma of Head and Neck; Carcinoma, Merkel Cell; Esophageal Neoplasms; HIV Infections; Ovarian Neoplasms Details
BNT-152 BNT-152 Phase 1 Clinical Biontech Se Solid tumours Details
Lusvertikimab OSE-127; S-95011; Effi-7; OSE-217 Phase 2 Clinical Effimune Sjogren's Syndrome; Colitis, Ulcerative Details
ASP-9801 ASP-9801 Phase 1 Clinical Astellas Pharma Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details

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