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Your Position: Home > IL-7 R alpha

IL-7 R alpha

Brief Information

Name:Interleukin-7 receptor subunit alpha
Target Synonym:Interleukin-7 receptor subunit alpha,Interleukin 7 Receptor Isoform H5-6,CDw127,IL-7R subunit alpha,IL-7RA,IL-7 receptor subunit alpha,CD127 Antigen,IL-7R-Alpha,Interleukin 7 Receptor Alpha Chain,CD127,IL7RA,ILRA,Interleukin-7 Receptor alpha Subunit
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

IL7-H5258-SPR
 IL-7 R alpha SPR

Captured Human IL-7 R alpha, Mouse IgG2a Fc Tag (Cat. No. IL7-H5258) on CM5 chip via anti-mouse antibodies surface can bind ActiveMax® Human IL-7, Tag Free (Cat. No. IL7-H4219) with an affinity constant of 13.3 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

IL7-H5258-ELISA
 IL-7 R alpha ELISA

Immobilized ActiveMax® Human IL-7, Tag Free (Cat. No. IL7-H4219) at 2 μg/mL (100 μL/well) can bind Human IL-7 R alpha, Mouse IgG2a Fc Tag (Cat. No. IL7-H5258) with a linear range of 4-31 ng/mL (QC tested).

Synonym Name

IL7Ra,CD127

Background

Interleukin-7 receptor subunit alpha (IL7Ra) is also known as CD antigen CD127, which belongs to the type I cytokine receptor family and type 4 subfamily. IL7Ra /CD127 contains 1 fibronectin type-III domain. IL7Ra /CD127 is expressed on various cell types, including naive and memory T cells and many others. IL7Ra /CD127 is receptor for interleukin-7 and also acts as a receptor for thymic stromal lymphopoietin (TSLP). The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PF-06342674 RN-168; PF-6342674; PF-06342674 Pfizer Inc Details
ASP-9801 ASP-9801 Phase 1 Clinical Astellas Pharma Inc Solid tumours Details
Efineptakin alfa NT-I7; GX-I7; TJ-107 Phase 2 Clinical Genexine Inc Pancreatic Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Laryngeal Neoplasms; Carcinoma, Squamous Cell; Glioma; Oropharyngeal Neoplasms; Lymphopenia; Colorectal Neoplasms; Leukopenia; Breast Neoplasms; Urinary Bladder Neoplasms; Ovarian Neoplasms; Triple Negative Breast Neoplasms; Hypopharyngeal Neoplasms; Small Cell Lung Carcinoma; Papillomavirus Infections; Glioblastoma; Coronavirus Disease 2019 (COVID-19); Carcinoma, Merkel Cell; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Solid tumours Details
Lusvertikimab OSE-127; S-95011 Phase 2 Clinical Effimune Sjogren's Syndrome; Colitis, Ulcerative Details
Interleukin-7 (Revimmune SAS) rhIL-7; CYT-107; CYT-99-007 Phase 2 Clinical Cytheris HIV Infections; Kidney Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Shock, Septic; Hepatitis B, Chronic; Coronavirus Disease 2019 (COVID-19); Sepsis; Mycobacterium Infections, Nontuberculous; Myeloproliferative Disorders; Breast Neoplasms; Lymphopenia; Hepatitis C; Leukemia, Myeloid, Acute; Melanoma Details
MDK-703 MDK-703 Phase 1 Clinical Details

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