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Your Position: Home > IL-7 R alpha

IL-7 R alpha

Brief Information

Name:Interleukin-7 receptor subunit alpha
Target Synonym:Interleukin-7 receptor subunit alpha,Interleukin 7 Receptor Isoform H5-6,CDw127,IL-7R subunit alpha,IL-7RA,IL-7 receptor subunit alpha,CD127 Antigen,IL-7R-Alpha,Interleukin 7 Receptor Alpha Chain,CD127,IL7RA,ILRA,Interleukin-7 Receptor alpha Subunit
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

IL7-H5258-SPR
 IL-7 R alpha SPR

Captured Human IL-7 R alpha, Mouse IgG2a Fc Tag (Cat. No. IL7-H5258) on CM5 chip via anti-mouse antibodies surface can bind ActiveMax® Human IL-7, Tag Free (Cat. No. IL7-H4219) with an affinity constant of 13.3 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

IL7-H82F9-ELISA
 IL-7 R alpha ELISA

Immobilized Human IL-7, Fc Tag (Cat. No. IL7-H5253) at 2 μg/mL (100 μL/well) can bind Biotinylated Human IL-7 R alpha Protein, Fc,Avitag (Cat. No. IL7-H82F9) with a linear range of 1-20 ng/mL (QC tested).

Synonym Name

IL7Ra,CD127

Background

Interleukin-7 receptor subunit alpha (IL7Ra) is also known as CD antigen CD127, which belongs to the type I cytokine receptor family and type 4 subfamily. IL7Ra /CD127 contains 1 fibronectin type-III domain. IL7Ra /CD127 is expressed on various cell types, including naive and memory T cells and many others. IL7Ra /CD127 is receptor for interleukin-7 and also acts as a receptor for thymic stromal lymphopoietin (TSLP). The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Interleukin-7 (Revimmune SAS) rhIL-7; CYT-107; CYT-99-007 Phase 2 Clinical Revimmune Inc Prostatic Neoplasms, Castration-Resistant; Neuroectodermal Tumors, Primitive, Peripheral; Catheter-Related Infections; Rhabdomyosarcoma, Alveolar; T-Lymphocytopenia, Idiopathic CD4-Positive; Leukemia, Myeloid, Acute; Metastatic breast cancer; Hepatitis C; Ureteral Neoplasms; Urologic Neoplasms; Lymphopenia; Sarcoma; Neuroblastoma; Prostatic Neoplasms; Urethral Neoplasms; Multiple Myeloma; HIV Infections; Urinary Bladder Neoplasms; Myeloproliferative Disorders; Sepsis; Carcinoma, Transitional Cell; Coronavirus Disease 2019 (COVID-19); Mycobacterium Infections, Nontuberculous; Myelodysplastic Syndromes; Rhabdomyosarcoma, Embryonal; Hepatitis B, Chronic; Carcinoma, Renal Cell; Leukemia, Myelogenous, Chronic; Kidney Neoplasms; Skin Melanoma; Shock, Septic Details
Lusvertikimab S-95011; Effi-7; OSE-217; OSE-127 Phase 2 Clinical Effimune Sjogren's Syndrome; Colitis, Ulcerative Details
Efineptakin alfa TJ-107; GX-I7; NT-I7 Phase 2 Clinical Genexine Inc Urinary Bladder Neoplasms; Sarcoma, Kaposi; Melanoma; Carcinoma, Non-Small-Cell Lung; Laryngeal Neoplasms; Leukoencephalopathy, Progressive Multifocal; Carcinoma, Squamous Cell; Glioma; Oropharyngeal Neoplasms; Gliosarcoma; Lymphopenia; Astrocytoma; Colorectal Neoplasms; Plasmablastic Lymphoma; Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Solid tumours; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Papillomavirus Infections; Hypopharyngeal Neoplasms; Lymphoma, Large B-Cell, Diffuse; Glioblastoma; Triple Negative Breast Neoplasms; Coronavirus Disease 2019 (COVID-19); Carcinoma, Merkel Cell; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; HIV Infections; Ovarian Neoplasms; Lymphoma, B-Cell Details
ASP-9801 ASP-9801 Phase 1 Clinical Astellas Pharma Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details
PF-06342674 RN-168; PF-6342674; PF-06342674; ZB-168 Phase 1 Clinical Pfizer Inc Diabetes Mellitus, Type 1; Multiple Sclerosis Details
Loco-regional B7H3 IL-7Ra CAR T Cell therapy(Chulalongkorn University) Phase 1 Clinical Chulalongkorn University, King Chulalongkorn Memorial Hospital Solid tumours; Neoplasms; Brain Neoplasms; Diffuse Intrinsic Pontine Glioma Details
MDK-703 MDK-703 Phase 1 Clinical Medikine Inc Solid tumours Details

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