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LDL R Molecule Information

Name:LDL receptor
Target Synonym:LDLR;LDL receptor;Low-density lipoprotein receptor
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase ?

LDL R Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
LDR-R5255 Rabbit Rabbit LDL R Protein, Fc Tag
LDR-H82E7 Human Biotinylated Human LDL R Protein, His,Avitag™
LDR-C5222 Cynomolgus Cynomolgus LDL R Protein, His Tag
LDR-H5254 Human Human LDL R Protein, Fc Tag
LDR-M52H8 Mouse Mouse LDL R Protein, His Tag
LDR-H5224 Human Human LDL R Protein, His Tag

LDL R Part of Bioactivity data


Loaded Human PCSK9, Fc Tag (Cat. No. PC9-H5256) on Protein A Biosensor, can bind Cynomolgus LDL R, His Tag (Cat. No. LDR-C5222) with an affinity constant of 1.24 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).


Loaded Human LDL R, Fc Tag (Cat. No. LDR-H5254) on Protein A Biosensor, can bind Human PCSK9, His Tag (Cat. No. PC9-H5223) with an affinity constant of 4.39 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

LDL R Molecule Synonym Name


LDL R Molecule Background

Low-Density Lipoprotein (LDL) Receptor is also known  as LDLR, FH, FHC, LDLCQ2, and is a mosaic protein of ~840 amino acids (after removal of signal peptide) that mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). It belongs to the Low density lipoprotein receptor gene family. LDL receptor complexes are present in clathrin-coated pits (or buds) on the cell surface, which when bound to LDL-cholesterol via adaptin, are pinched off to form clathrin-coated vesicles inside the cell. This allows LDL-cholesterol to be bound and internalized in a process known as endocytosis and prevents the LDL just diffusing around the membrane surface. This occurs in all nucleated cells (not erythrocytes), but mainly in the liver which removes ~70% of LDL from the circulation. Synthesis of receptors in the cell is regulated by the level of free intracellular cholesterol; if it is in excess for the needs of the cell then the transcription of the receptor gene will be inhibited. LDL receptors are translated by ribosomes on the endoplasmic reticulum and are modified by the Golgi apparatus before travelling in vesicles to the cell surface. LDL is directly involved in the development of atherosclerosis, due to accumulation of LDL-cholesterol in the blood. Atherosclerosis is the process responsible for the majority of cardiovascular diseases.

LDL R References

LDL R Related Molecule

LDL R Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CP-230821 CP-230821 Preclinical Pfizer Atherosclerosis, Hypercholesterolemia Details
Phosphorylcholine monoclonal antibody PC-mAb Phase Ⅱ Dyax Pharma, Athera Cardiovascular disorders, Atherosclerosis Details
ANG-2008 (AngioChem) ANG-2008,ANG 2008,ANG2008 Preclinical AngioChem Parkinson's disease (PD) Details
Axitirome CGP-26214; CGS-26214; CGP 26214; CGS 26214 Phase Ⅰ Novartis Hyperlipidemia Details
Serpin Peptide 16 SP-16,SP16 Phase Ⅱ Serpin Pharma Inflammation, Myocardial infarction (MI) Details
LLG-783 (Novartis) LLG-783 Phase Ⅱ Novartis Intermittent claudication, Peripheral arterial disease (PAD) Details
CVI-LM001 C-8304; CVI-LM001 Phase Ⅱ CVI Pharmaceuticals Hyperlipidemia Details
Paclitaxel trevatide ANG-1005; GRN-1005; SNG-1005 Phase Ⅲ AngioChem, Xinogen Pharma Glioma, Breast cancer, Glioblastoma, Brain metastases Details

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