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Your Position: Home > LIF

LIF

Brief Information

Name:Leukemia inhibitory factor
Target Synonym:LIF Interleukin 6 Family Cytokine,D factor,Emfilermin,LIF,Differentiation-stimulating factor,LIF, Interleukin 6 Family Cytokine,Differentiation Inhibitory Activity,Cholinergic Differentiation Factor,Hepatocyte-Stimulating Factor III,Differentiation-Induci
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Part of Bioactivity data

LIF-H82E2-ELISA
Biotinylated Human LIF, His,AvitagBiotinylated Human LIF, His,Avitag (Cat. No. LIF-H82E2) ELISA bioactivity

Immobilized Biotinylated Human LIF, His,Avitag (Cat. No. LIF-H82E2) on SA-coated surface at 1 μg/mL (100 μL/well) can bind Human LIF R, Fc Tag (Cat. No. LIR-H4252) with a linear range of 1-31 ng/mL (QC tested).

LIF-H52H3-MALS-HPLC
Human LIF, His Tag (Cat. No. ) MALS images

The purity of Human LIF, His Tag (Cat. No. LIF-H52H3) was more than 85% and the molecular weight of this protein is around 28-42 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human LIF, His TagHuman LIF, His Tag (Cat. No. LIF-H52H3) ELISA bioactivity

Immobilized Human LIF, His Tag (Cat. No. LIF-H52H3) at 5 μg/mL (100 μL/well) can bind Human LIF R, Fc Tag (Cat. No. LIR-H4252) with a linear range of 1-20 ng/mL (QC tested).

Synonym Name

LIF,CDF,DIA,HILDA,MLPLI

Background

Leukemia inhibitory factor, or LIF, an interleukin 6 class cytokine, is a protein in cells that affects cell growth and development.Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Removal of LIF pushes stem cells toward differentiation, but they retain their proliferative potential or pluripotency. Therefore LIF is used in mouse embryonic stem cell culture. It is necessary to maintain the stem cells in an undifferentiated state, however genetic manipulation of embryonic stem cells allows for LIF independent growth, notably overexpression of the gene Nanog. LIF is not required for culture of human embryonic stem cells.

Clinical and Translational Updates

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