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Your Position: Home > LIF


Brief Information

Name:Leukemia inhibitory factor
Target Synonym:LIF Interleukin 6 Family Cytokine,D factor,Emfilermin,LIF,Differentiation-stimulating factor,LIF, Interleukin 6 Family Cytokine,Differentiation Inhibitory Activity,Cholinergic Differentiation Factor,Hepatocyte-Stimulating Factor III,Differentiation-Inducing Factor,Melanoma-Derived LPL Inhibitor,Human Interleukin In DA Cells,Leukemia Inhibitory Factor,HILDA,MLPLI,CDF,DIA
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

LIF-H521b-Cell-based assay

Human LIF Protein, premium grade (Cat. No. LIF-H521b) stimulates the proliferation of TF-1 cells. The EC50 for this effect is 0.678 ng/mL (Routinely tested).


Immobilized Biotinylated Human LIF, His,Avitag (Cat. No. LIF-H82E2) on SA-coated surface at 1 μg/mL (100 μL/well) can bind Human LIF R, Fc Tag (Cat. No. LIR-H4252) with a linear range of 1-31 ng/mL (QC tested).

LIF MALS images

The purity of Mouse LIF Protein, Tag Free (Cat. No. LIF-M5219) is more than 95% and the molecular weight of this protein is around 26-40 kDa verified by SEC-MALS.

Synonym Name



Leukemia inhibitory factor, or LIF, an interleukin 6 class cytokine, is a protein in cells that affects cell growth and development.Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Removal of LIF pushes stem cells toward differentiation, but they retain their proliferative potential or pluripotency. Therefore LIF is used in mouse embryonic stem cell culture. It is necessary to maintain the stem cells in an undifferentiated state, however genetic manipulation of embryonic stem cells allows for LIF independent growth, notably overexpression of the gene Nanog. LIF is not required for culture of human embryonic stem cells.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Falbikitug AZD-0171 Phase 2 Clinical Astrazeneca Plc Solid tumours Details
MSC-1 MSC-1 Phase 1 Clinical Northern Biologics Inc Ovarian Neoplasms; Solid tumours; Pancreatic Neoplasms; Carcinoma, Non-Small-Cell Lung Details
JAB-BX300 JAB-BX300 Phase 1 Clinical Jacobio Pharmaceuticals Co Ltd Solid tumours; Pancreatic Neoplasms Details

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