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LIF

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Cat. No. Species Product Description Structure Purity Feature
LIF-H82E2 Human Biotinylated Human LIF Protein, His,Avitag™
LIF-H82E2-structure
LIF-H82E2-sds
LIF-H82E2-elisa_1
LIF-M5227 Mouse Mouse LIF Protein, His Tag
LIF-M5227-structure
LIF-M5227-sds
LIF-H521b Human ActiveMax® Human LIF Protein, Tag Free
LIF-H521b-structure
LIF-H521b-sds
LIF-H521b-elisa_1

LIF Molecule Synonym Name

LIF,CDF,DIA,HILDA,MLPLI

LIF Molecule Background

Leukemia inhibitory factor, or LIF, an interleukin 6 class cytokine, is a protein in cells that affects cell growth and development.Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Removal of LIF pushes stem cells toward differentiation, but they retain their proliferative potential or pluripotency. Therefore LIF is used in mouse embryonic stem cell culture. It is necessary to maintain the stem cells in an undifferentiated state, however genetic manipulation of embryonic stem cells allows for LIF independent growth, notably overexpression of the gene Nanog. LIF is not required for culture of human embryonic stem cells.

LIF References

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