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Your Position: Home > LIF


Brief Information

Name:Leukemia inhibitory factor
Target Synonym:LIF Interleukin 6 Family Cytokine,D factor,Emfilermin,LIF,Differentiation-stimulating factor,LIF, Interleukin 6 Family Cytokine,Differentiation Inhibitory Activity,Cholinergic Differentiation Factor,Hepatocyte-Stimulating Factor III,Differentiation-Inducing Factor,Melanoma-Derived LPL Inhibitor,Human Interleukin In DA Cells,Leukemia Inhibitory Factor,HILDA,MLPLI,CDF,DIA
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

Biotinylated Human LIF, His,AvitagBiotinylated Human LIF, His,Avitag (Cat. No. LIF-H82E2) ELISA bioactivity

Immobilized Biotinylated Human LIF, His,Avitag (Cat. No. LIF-H82E2) on SA-coated surface at 1 μg/mL (100 μL/well) can bind Human LIF R, Fc Tag (Cat. No. LIR-H4252) with a linear range of 1-31 ng/mL (QC tested).

LIF MALS images

The purity of ActiveMax® Mouse LIF, Tag Free(Cat. No. LIF-M5219) is more than 95% and the molecular weight of this protein is around 26-40 kDa verified by SEC-MALS.

Synonym Name



Leukemia inhibitory factor, or LIF, an interleukin 6 class cytokine, is a protein in cells that affects cell growth and development.Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Removal of LIF pushes stem cells toward differentiation, but they retain their proliferative potential or pluripotency. Therefore LIF is used in mouse embryonic stem cell culture. It is necessary to maintain the stem cells in an undifferentiated state, however genetic manipulation of embryonic stem cells allows for LIF independent growth, notably overexpression of the gene Nanog. LIF is not required for culture of human embryonic stem cells.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AZD-0171 AZD-0171 Phase 2 Clinical Astrazeneca Plc Solid tumours Details

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