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LTBR

Brief Information

Name:Tumor necrosis factor receptor superfamily member 3
Target Synonym:Lymphotoxin-beta receptor,Tumor necrosis factor receptor type III,LTBR,Tumor necrosis factor receptor superfamily member 3,D12S370,TNFRSF3,TNFCR,TNFR3,TNFR Superfamily, Member 3,Lymphotoxin B Receptor,LT-BETA-R,TNF-R-III,TNFR2-RP,TNF-RIII,TNFR-III,TNFR-RP
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Discontinued

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Cat. No. Species Product Description Structure Purity Feature
LTR-H5251 Human Human LTBR / TNFRSF3 Protein, Fc Tag
LTR-H5251-structure
LTR-H5251-sds
LTR-H5251-elisa_1

Part of Bioactivity data

LTR-H5251-ELISA
Human LTBR, Fc TagHuman LTBR, Fc Tag (Cat. No. LTR-H5251) ELISA bioactivity

Immobilized Human LTBR, Fc Tag (Cat. No. LTR-H5251) at 5 μg/mL (100 μL/well) can bind Human LIGHT, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. LIT-H5256) with a linear range of 0.3-5 ng/mL (QC tested).

Synonym Name

LTBR,D12S370,TNFCR,TNFR3,TNFRSF3,TNFRIII

Background

Lymphotoxin-beta receptor (LTBR) is also known as Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), Tumor necrosis factor receptor type III (TNF-RIII), which is a single-pass type I membrane protein containing four TNFR-Cys repeat regions. Except for interacting with HCV core protein, LTBR can not only associate with itself, but also can associate with TRAF3, TRAF4 and TRAF5. As the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT, LTBR promotes apoptosis via TRAF3 and TRAF5. Furthermore, LTBR may play a role in the development of lymphoid organs.

Clinical and Translational Updates

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