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Your Position: Home > LTBR

LTBR

Brief Information

Name:Tumor necrosis factor receptor superfamily member 3
Target Synonym:Lymphotoxin-beta receptor,Tumor necrosis factor receptor type III,LTBR,Tumor necrosis factor receptor superfamily member 3,D12S370,TNFRSF3,TNFCR,TNFR3,TNFR Superfamily, Member 3,Lymphotoxin B Receptor,LT-BETA-R,TNF-R-III,TNFR2-RP,TNF-RIII,TNFR-III,TNFR-RP,Lymphotoxin beta Receptor,Tumor necrosis factor C receptor,Tumor Necrosis Factor Receptor 2-Related Protein,Lymphotoxin Beta Receptor (TNFR Superfamily, Member 3)
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Discontinued

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Cat. No. Species Product Description Structure Purity Feature
LTR-HP2H3 Human PE-Labeled Human LTBR / TNFRSF3 Protein, His Tag
LTR-HP2H3-structure
LTR-H5259 Human Human LTBR / TNFRSF3 Protein, Fc Tag
LTR-H5259-structure
LTR-H5259-sds
LTR-H82E9 Human Biotinylated Human LTBR / TNFRSF3 Protein, His,Avitag™ (MALS verified)
LTR-H82E9-structure
LTR-H82E9-sds
ACRO Quality

Part of Bioactivity data

LTR-H82E9-ELISA
LTBR ELISA

Immobilized Biotinylated Human LTBR, His,Avitag (Cat. No. LTR-H82E9) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Human LIGHT, Fc Tag (active trimer) (MALS verified) (Cat. No. LIT-H5269) with a linear range of 0.1-8 ng/mL (QC tested).

Protocol
LTR-H82E9-MALS-HPLC
LTBR MALS images

The purity of Biotinylated Human LTBR, His,Avitag (Cat. No. LTR-H82E9) is more than 95% and the molecular weight of this protein is around 26-38 kDa verified by SEC-MALS.

Synonym Name

LTBR,D12S370,TNFCR,TNFR3,TNFRSF3,TNFRIII

Background

Lymphotoxin-beta receptor (LTBR) is also known as Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), Tumor necrosis factor receptor type III (TNF-RIII), which is a single-pass type I membrane protein containing four TNFR-Cys repeat regions. Except for interacting with HCV core protein, LTBR can not only associate with itself, but also can associate with TRAF3, TRAF4 and TRAF5. As the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT, LTBR promotes apoptosis via TRAF3 and TRAF5. Furthermore, LTBR may play a role in the development of lymphoid organs.

Clinical and Translational Updates

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