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Your Position: Home > MICA

MICA

Brief Information

Name:MHC class I polypeptide-related sequence A
Target Synonym:
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
MIA-H5259 Human Human MICA Protein, IgG4 Fc Tag
MIA-H5259-structure
MIA-H5259-sds
MIA-H5256 Human Human MICA (24-202) Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified)
MIA-H5256-structure
MIA-H5256-sds
MIA-H52H7 Human Human MICA (24-202) Protein, His Tag (MALS verified)
MIA-H52H7-structure
MIA-H52H7-sds
MIA-C52H5 Cynomolgus Cynomolgus MICA Protein, His Tag (HPLC verified)
MIA-C52H5-structure
MIA-C52H5-sds
MIA-C52H5-hplc
MIA-H5255 Human Human MICA (24-202) Protein, Mouse IgG2a Fc Tag (MALS verified)
MIA-H5255-structure
MIA-H5255-sds
MIA-H5254 Human Human MICA (24-309) Protein, Fc Tag (MALS verified)
MIA-H5254-structure
MIA-H5254-sds
MIA-H82Q7 Human Biotinylated Human MICA (201-309) Protein, His,Avitag™
MIA-H82Q7-structure
MIA-H82Q7-sds
MIA-H82F6 Human Biotinylated Human MICA Protein, Fc,Avitag™ (MALS verified)
MIA-H82F6-structure
MIA-H82F6-sds
MIA-H82E4 Human Biotinylated Human MICA (201-309) Protein, His,Avitag™ (MALS verified)
MIA-H82E4-structure
MIA-H82E4-sds
MIA-H82E6 Human Biotinylated Human MICA Protein, His,Avitag™ (MALS verified)
MIA-H82E6-structure
MIA-H82E6-sds
MIA-H5253 Human Human MICA Protein, Fc Tag
MIA-H5253-structure
MIA-H5253-sds
MIA-H5221 Human Human MICA Protein, His Tag (MALS verified)
MIA-H5221-structure
MIA-H5221-sds
ACRO Quality

Part of Bioactivity data

MIA-H5256-ELISA
MICA ELISA

Immobilized Human NKG2D, His Tag (Cat. No. NKD-H5245) at 2 μg/mL (100 μL/well) can bind Human MICA (24-202) Protein, Llama IgG2b Fc Tag (Cat. No. MIA-H5256) with a linear range of 0.1-2 ng/mL (QC tested).

Protocol
MIA-H5256-MALS-HPLC
MICA MALS images

The purity of Human MICA (24-202) Protein, Llama IgG2b Fc Tag (Cat. No. MIA-H5256) is more than 85% and the molecular weight of this protein is around 100-125 kDa verified by SEC-MALS.

Synonym Name

MIC-A

Background

MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CLN-619 CLN-619 Phase 1 Clinical PDI Therapeutics Inc Solid tumours; Multiple Myeloma Details
FT-536 FT-536 Phase 1 Clinical Fate Therapeutics Inc Solid tumours; Ovarian Neoplasms; Abdominal Neoplasms; Genital Neoplasms, Female; Fallopian Tube Neoplasms Details
DM-919 DM-919; DM919 Phase 1 Clinical D2M Biotherapeutics Inc Solid tumours; Neoplasms Details

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