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Your Position: Home > Oncostatin M

Oncostatin M

Brief Information

Name:Oncostatin M
Target Synonym:Oncostatin-M,OSM,Oncostatin M,MGC20461
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

OSM-H5213-ELISA
ActiveMax® Human Oncostatin M, Tag FreeActiveMax® Human Oncostatin M, Tag Free (Cat. No. OSM-H5213) ELISA bioactivity

Immobilized ActiveMax® Human Oncostatin M, Tag Free (Cat. No. OSM-H5213) at 5 μg/mL (100 μL/well) can bind Human LIF R, Fc Tag (Cat. No. LIR-H4252) with a linear range of 0.01-0.156 μg/mL (QC tested).

OSM-H82Q8-ELISA
Biotinylated Human Oncostatin M, Avitag,His TagBiotinylated Human Oncostatin M, Avitag,His Tag (Cat. No. OSM-H82Q8) ELISA bioactivity

Immobilized Biotinylated Human Oncostatin M, Avitag,His Tag (Cat. No. OSM-H82Q8) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Human LIF R, Fc Tag (Cat. No. LIR-H4252) with a linear range of 0.02-1.25 μg/mL (QC tested).

Synonym Name

OSM,MGC20461,Oncostatin M

Background

Oncostatin M is also known as OSM, is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also associated with bone formation and destruction. OSM signals through cell surface receptors that contain the protein gp130. The type I receptor is composed of gp130 and LIFR, the type II receptor is composed of gp130 and OSMR. Oncostatin M (OSM) was previoustly identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. It also has been reported that OSM, like LIF, IL-6 and G-CSF, has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH2 and 11 and resistant to heating for one hour at 56 degree but is not stable at 90 degrees. The three dimensional structure of human OSM has been solved to atomic resolution, confirming the predicted long chain four helix bundle topology. Comparing this structure with the known structures of other known LC cytokines shows it to be most closely related to LIF.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
GSK-2330811 GSK-2330811 Phase 2 Clinical Glaxosmithkline Plc Scleroderma, Systemic; Crohn Disease Details

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