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Activin A

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Cat. No. Species Product Description Structure Purity Feature
ACA-H421b Human Human Activin A / INHBA Protein, premium grade
ACA-H421b-structure
ACA-H421b-sds
ACA-H424x Human Human Latent Activin A / INHBA Protein, His Tag
ACA-H424x-structure
ACA-H424x-sds

Part of Bioactivity data

ACA-H421b-Cell-based assay
 Activin A CELL

The bio-activity of Human Activin A, premium grade (Cat. No. ACA-H421b) was determined by dose-dependent inhibition of the proliferation of MPC-11 cells. The EC50 for this effect is typically ≤ 9.5 ng/mL (Routinely tested).

ACA-H424x-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

The bio-activity of Human Latent Activin A, His Tag (Cat. No. ACA-H424x) was determined by dose-dependent inhibition of the proliferation of MPC-11 cells. The EC50 for this effect is typically 47-66 ng/mL (Routinely tested).

ACA-H424x-ELISA
Human Latent Activin A, His TagHuman Latent Activin A, His Tag (Cat. No. ACA-H424x) ELISA bioactivity

Immobilized Human Latent Activin A, His Tag (Cat. No. ACA-H424x) at 10 μg/mL (100 μL/well) can bind Human ACVR2A, Fc Tag (Cat. No. ACA-H5269) with a linear range of 0.6-20 ng/mL (QC tested).

ACA-H421b-ELISA
 Activin A ELISA

Immobilized Human Activin A, premium grade (Cat. No. ACA-H421b) at 5 μg/mL (100 μL/well) can bind Human ACVR2A, Fc Tag (Cat. No. ACA-H5269) with a linear range of 0.4-25 ng/mL (QC tested).

Synonym Name

Activin A,INHBA

Background

Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.Activins are nonglycosylated homodimers or heterodimers of various ¦Â subunits (¦ÂA, ¦ÂB, ¦ÂC, and ¦ÂE in mammals), while Inhibins are heterodimers of a unique ¦Á subunit and one of the ¦Â subunits. Activin A is a widely expressed homodimer of two ¦ÂA chains. The ¦ÂA subunit can also heterodimerize with a ¦ÂB or ¦ÂC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human ¦ÂA chain shares 100% amino acid sequence identity with bovine, feline, mouse, porcine, and rat ¦ÂA.

Clinical and Translational Updates

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