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Brief Information

Name:Programmed death-ligand 2
Target Synonym:PDCD1LG2,PDL2,Programmed death ligand 2,CD273,Butyrophilin B7-DC,PD-1 ligand 2,B7-DC,BA574F11.2,PDCD1L2,CD273 Antigen,B7DC,Btdc,B7 Dendritic Cell Molecule,PD-1-Ligand 2,PDCD1 ligand 2,Programmed cell death 1 ligand 2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Part of Bioactivity data

PD2-H52A5-Cell-based assay

Flow Cytometry assay shows that Human PD-L2, Mouse IgG1 Fc Tag (Cat. No. PD2-H52A5) can bind to 293 cell overexpressing human PD-1. The concentration of PD-L2 used is 0.1 μg/mL (Routinely tested).

PD2-H52A5-Cell-based assay

FACS analysis shows that the binding of Human PD-L2, Mouse IgG1 Fc Tag (Cat. No. PD2-H52A5) to 293 overexpressing PD-1 was inhibited by increasing concentration of neutralizing Anti-PD-1 antibody. The concentration of PD-L2 used is 0.1 μg/mL. The IC50 is 1.3 μg/mL (Routinely tested).


Captured Human PD-L2 Protein, His Tag (Cat. No. PD2-H5220) on CM5 Chip via anti-His antibody can bind Human PD-1, Fc Tag (Cat. No. PD1-H5257) with an affinity constant of 24.9 nM as determined in SPR assay (Biacore T200) (QC tested).


Loaded Mouse PD-1, Fc Tag (Cat. No. PD1-M5259) on Protein A Biosensor, can bind Mouse PD-L2, His Tag (Cat. No. PD2-M52E3) with an affinity constant of 0.13 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

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Synonym Name

PDL2,PD-L2,Butyrophilin B7-DC,CD273,PDCD1 ligand 2,PDCD1L2,PDCD1LG2


Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
IMGS-001 IMGS-001 Phase 1 Clinical The University Of Texas MD Anderson Cancer Center Solid tumours; Neoplasms; Triple Negative Breast Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms Details

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