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Serpin D1

Serpin D1 Product List

Cat. No. Species Product Description Structure Purity Feature
HC2-H5224 Human Human Serpin D1 / Heparin Cofactor II Protein
HC2-H5224-structure
HC2-H5224-sds

Serpin D1 Molecule Synonym Name

SerpinD1,HCF2,HLS2,HC-II

Serpin D1 Molecule Background

Serpin D1 is also known as Heparin cofactor 2 (HCF2), Protease inhibitor leuserpin-2 (HLS2), Heparin cofactor II (HC-II), which belongs to the serpin family. HCF2 is expressed predominantly in liver. Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, SerpinD1 / HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). In a glycosaminoglycan-independent manner, serpinD1 / HC-II also inhibits chymotrypsin. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.

Serpin D1 References

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