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Sonic Hedgehog

Sonic Hedgehog Overview

English NameSonic Hedgehog HomologApproved Drugs0
Drugs in Clinical Trials4Target SynonymHHG-1，Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains，ShhNC，Shh N-terminal processed signaling domains，ShhNp，ShhN，Sonic hedgehog protein，Sonic hedgehog protein N-product，Sonic Hedgehog Signaling Molecule，Sonic Hedgehog (Drosophila) Homolog
Highest Development StagePhase 2 Clinical
English NameSonic Hedgehog Homolog
Target SynonymHHG-1，Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains，ShhNC，Shh N-terminal processed signaling domains，ShhNp，ShhN，Sonic hedgehog protein，Sonic hedgehog protein N-product，Sonic Hedgehog Signaling Molecule，Sonic Hedgehog (Drosophila) Homolog
Approved Drugs0
Drugs in Clinical Trials4
Highest Development StagePhase 2 Clinical

Sonic Hedgehog Product List

  • Product Category

    Protein (4)

  • Product Status

    Launched (4)

  • Species

    Human (4)

  • Tag

    His Tag (1)Tag Free (3)

  • Conjugate

    Unconjugated (4)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeature
GMP-SH7H13
Human
E. coli
GMP Human Sonic Hedgehog / Shh (C24II) Protein
SH7-H5116
Human
E. coli
Human Sonic Hedgehog / Shh (C24II) Protein, premium grade
SH7-H5117
Human
E. coli
Human Sonic Hedgehog / Shh (C24II) Protein, Research Grade
SH7-H5229
Human
HEK293
Human Sonic Hedgehog / Shh Protein, His Tag, premium grade
Total: 4
  • 1

Sonic Hedgehog Background

Sonic hedgehog protein (SHH) is also known as HHG-1, which belongs to the hedgehog family. SHH is expressed in fetal intestine, liver, lung, and kidney and not expressed in adult tissues. Sonic hedgehog protein can be cleavage into sonic hedgehog protein N-product and sonic hedgehog protein C-product by autolysis. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development. The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.

Sonic Hedgehog Synonyms

SHH,HHG-1,Sonic hedgehog,HLP3,HPE3,SMMCI,TPT,TPTPS

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
ACC-006ACC-006Phase 2 ClinicalChina Pharmaceutical University, Jiangsu Aidea Pharmaceutical Group Co LtdCarcinoma, Non-Small-Cell Lung; Solid tumours
Details
Sulforafan alfadexSFX-01; STP-2Phase 2 ClinicalEvgen Pharma, Lalilab, Pharmagra Labs IncAsthma; Autism Spectrum Disorder; Autistic Disorder; Breast Neoplasms; Carcinoma in Situ; Drug-Related Side Effects and Adverse Reactions; Head and Neck Neoplasms; Heart Diseases; Heart Failure, Diastolic; Hyperplasia; Kidney Diseases; Lung Neoplasms; Melanoma; Nasolabial fold wrinkles; Neoplasms; Neurodevelopmental Disorders; Parkinson Disease; Precancerous Conditions; Prostatic Neoplasms; Renal Insufficiency, Chronic; Schizophrenia; Squamous Cell Carcinoma of Head and Neck; Subarachnoid Hemorrhage; Ventricular Dysfunction, Left
Details
NLM-001NLM-001; TAK-441Phase 2 ClinicalMillennium Pharmaceuticals IncCarcinoma, Basal Cell; Carcinoma, Pancreatic Ductal; Neoplasms
Details
IMP5471-CAPhase 1 ClinicalShanghai Impact Pharmaceutical Co LtdHematologic Diseases
Details
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  • Clinical Drug Information
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