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Your Position: Home > Sonic Hedgehog

Sonic Hedgehog

Brief Information

Name:Sonic Hedgehog Homolog
Target Synonym:HHG-1,Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains,ShhNC,Shh N-terminal processed signaling domains,ShhNp,ShhN,Sonic hedgehog protein,Sonic hedgehog protein N-product,Sonic Hedgehog Signaling Molecule,Sonic Hedgehog (Drosophila) Homolog
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
SH7-H5229 Human Human Sonic Hedgehog / Shh Protein, His Tag

Synonym Name



Sonic hedgehog protein (SHH) is also known as HHG-1, which belongs to the hedgehog family. SHH is expressed in fetal intestine, liver, lung, and kidney and not expressed in adult tissues. Sonic hedgehog protein can be cleavage into sonic hedgehog protein N-product and sonic hedgehog protein C-product by autolysis. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development. The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
IMP5471-CA Phase 1 Clinical Shanghai Impact Pharmaceutical Co Ltd Hematologic Diseases Details
ACC-006 ACC-006 Phase 2 Clinical Jiangsu Aidea Pharmaceutical Co Ltd, China Pharmaceutical University Solid tumours; Carcinoma, Non-Small-Cell Lung Details

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