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Your Position: Home > TGF-beta RII

TGF-beta RII

Brief Information

Name:Transforming growth factor beta receptor 2
Target Synonym:NONHSAG034676,TGF-beta receptor type II,Transforming Growth Factor Beta Receptor 2,Transforming Growth Factor, Beta Receptor II Alpha,Transforming Growth Factor Beta Receptor Type IIC,Transforming growth factor-beta receptor type II,TbetaR-II,TGF-beta type II receptor,TGFBR2,Transforming Growth Factor, Beta Receptor II (70/80kDa),Transforming Growth Factor Beta Receptor II,TGFR-2,Transforming Growth Factor, Beta Receptor II Epsilon,Transforming Growth Factor, Beta Receptor II Delta,Transforming
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

TG2-H52H5-ELISA
Human TGF-beta RII, His TagHuman TGF-beta RII, His Tag (Cat. No. TG2-H52H5) ELISA bioactivity

Serial dilutions of Human TGF-beta RII, His Tag (Cat. No. TG2-H52H5) were added into Human Latent TGFB1, His Tag (Cat. No. TG1-H524x) : Biotinylated Human TGF-beta RII, His,Avitag (Cat. No. TG2-H82E4) binding reactions. The half maximal inhibitory concentration (IC50) is 0.39287 μg/mL (QC tested).

TG2-H82F6-MALS-HPLC
Biotinylated Human TGFBR2, Fc,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human TGFBR2, Fc,Avitag (Cat. No. TG2-H82F6) is more than 90% and the molecular weight of this protein is around 110-125 kDa verified by SEC-MALS.

Bioactivity-ELISA
Biotinylated Human TGFBR2, Fc,AvitagBiotinylated Human TGFBR2, Fc,Avitag (Cat. No. TG2-H82F6) ELISA bioactivity

Immobilized Human Latent TGFB1, His Tag (Cat. No. TG1-H524x) at 2 μg/mL (100 μL/well) can bind Biotinylated Human TGFBR2, Fc,Avitag (Cat. No. TG2-H82F6) with a linear range of 2-16 ng/mL (QC tested).

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Synonym Name

TGFBR2,TGFR2,TbetaR-II,TGFβR2

Background

TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I  receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
TASO-001 TASO-001; ATB-301 Details
IMC-TR1 IMC-TR1; LY-3022859 Eli Lilly And Company Details
Adoptive Cell Therapy (Oslo University Hospital) Oslo University Hospital Details
YH-14618 P2K; YH14618; Peniel 2K; Peniel-2000 Yuhan Corp Details
HCW-9218 HCW-9218 Phase 2 Clinical HCW Biologics Inc Solid tumours; Pancreatic Neoplasms; Pulmonary Fibrosis Details

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