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Your Position: Home > TGF-beta RII

TGF-beta RII

Brief Information

Name:Transforming growth factor beta receptor 2
Target Synonym:NONHSAG034676,TGF-beta receptor type II,Transforming Growth Factor Beta Receptor 2,Transforming Growth Factor, Beta Receptor II Alpha,Transforming Growth Factor Beta Receptor Type IIC,Transforming growth factor-beta receptor type II,TbetaR-II,TGF-beta type II receptor,TGFBR2,Transforming Growth Factor, Beta Receptor II (70/80kDa),Transforming Growth Factor Beta Receptor II,TGFR-2,Transforming Growth Factor, Beta Receptor II Epsilon,Transforming Growth Factor, Beta Receptor II Delta,Transforming
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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ACRO Quality

Part of Bioactivity data


Immobilized Human Latent TGFB1, His Tag (Cat. No. TG1-H524x) at 1 μg/mL (100 μL/well) can bind Biotinylated Mouse TGF-beta RII, His,Avitag (Cat. No. TG2-M82H5) with a linear range of 1-31 ng/mL (QC tested).

TGF-beta RII MALS images

The purity of Human TGF-beta RII Protein, Llama IgG2b Fc Tag (Cat. No. TG2-H5253) is more than 85% and the molecular weight of this protein is around 95-115 kDa verified by SEC-MALS.

Customer Reviews

Synonym Name



TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I  receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
HCW-9218 HCW-9218 Phase 2 Clinical HCW Biologics Inc Solid tumours; Pancreatic Neoplasms; Pulmonary Fibrosis Details
INCA33890 INCA33890; INCA-33890 Phase 1 Clinical Incyte Corp Solid tumours; Neoplasms; Neoplasm Metastasis Details
RG-6315 RG-6315 Phase 1 Clinical Genentech Inc Scleroderma, Systemic Details
TASO-001 TASO-001; ATB-301 Phase 1 Clinical Autotelicbio Co Ltd Solid tumours Details

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