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Your Position: Home > TGF-beta RII

TGF-beta RII

TGF-beta RII Molecule Information

Name:Transforming growth factor beta receptor 2
Target Synonym:EC:2.7.11.30,NONHSAG034676,Transforming growth factor-beta receptor type II,TbetaR-II,TGF-beta type II receptor,TGFBR2,Transforming Growth Factor, Beta Receptor II (70/80kDa),Transforming Growth Factor Beta Receptor II,TGFR-2,Transforming Growth Factor, B

Number of Launched Drugs:2
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

TGF-beta RII Protein Product ListCompare or Buy

Product> Filter Results

Cat. No.	Species	Product Description
TG2-M82H5	Mouse	Biotinylated Mouse TGF-beta RII / TGFBR2 Protein, His,Avitag™
TG2-H52H5	Human	Human TGF-beta RII / TGFBR2 Protein, His Tag (MALS verified)
TG2-H82E4	Human	Biotinylated Human TGF-beta RII / TGFBR2 Protein, His,Avitag™
TG2-H82F6	Human	Biotinylated Human TGF-beta RII / TGFBR2 Protein, Fc,Avitag™ (MALS verified)
TG2-H5252	Human	Human TGF-beta RII / TGFBR2 Protein, Fc Tag

TGF-beta RII Part of Bioactivity data

TG2-H52H5-ELISA

Serial dilutions of Human TGF-beta RII, His Tag (Cat. No. TG2-H52H5) were added into Human Latent TGFB1, His Tag (Cat. No. TG1-H524x) : Biotinylated Human TGF-beta RII, His,Avitag (Cat. No. TG2-H82E4) binding reactions. The half maximal inhibitory concentration (IC50) is 0.39287 μg/mL (QC tested).

Protocol

TG2-H82F6-MALS-HPLC

Biotinylated Human TGFBR2, Fc,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human TGFBR2, Fc,Avitag (Cat. No. TG2-H82F6) was more than 90% and the molecular weight of this protein is around 110-125 kDa verified by SEC-MALS.

Report

Bioactivity-ELISA

Biotinylated Human TGFBR2, Fc,AvitagBiotinylated Human TGFBR2, Fc,Avitag (Cat. No. TG2-H82F6) ELISA bioactivity

Immobilized Human Latent TGFB1, His Tag (Cat. No. TG1-H524x) at 2 μg/mL (100 μL/well) can bind Biotinylated Human TGFBR2, Fc,Avitag (Cat. No. TG2-H82F6) with a linear range of 2-16 ng/mL (QC tested).

TGF-beta RII Molecule Synonym Name

TGFBR2,TGFR2,TbetaR-II,TGFβR2

TGF-beta RII Molecule Background

TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.

TGF-beta RII References

TGF-beta RII Public Drug Information

Name	Research Code	Research Phase	Company	First Brand Name	First Approved Country	First Indication	First Approved Company	First Approved Date	Indications	Clinical Trials
Netarsudil Dimesylate	AR-13224; AR-13324	Approved	Aerie Pharmaceuticals	Rhopressa	EU	Ocular Hypertension; Glaucoma, Open-Angle	s:33:"Aerie Pharmaceuticals Ireland Ltd";	2017-12-18	Glaucoma, Open-Angle; Ocular Hypertension; Glaucoma; Corneal Edema; Fuchs' Endothelial Dystrophy	Details
Netarsudil mesylate/Latanoprost	PG-324	Approved	Aerie Pharmaceuticals Inc	Rocklatan, Roclanda	EU	Glaucoma, Open-Angle; Ocular Hypertension	s:33:"Aerie Pharmaceuticals Ireland Ltd";	2019-03-12	Glaucoma, Open-Angle; Ocular Hypertension	Details

TGF-beta RII Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
Adoptive Cell Therapy (Oslo University Hospital)		Phase 2 Clinical	Oslo University Hospital	Colorectal Neoplasms	Details
SHR-1701	SHR-1701	Phase 2 Clinical	Jiangsu Hengrui Medicine Co Ltd	Solid tumours; Squamous Cell Carcinoma of Head and Neck; Pancreatic Neoplasms; Nasopharyngeal Carcinoma; Prostatic Neoplasms; Carcinoma, Non-Small-Cell Lung	Details
Trabedersen	OT-101; OT-201; AP-2/09; AP-12009; AP-2/09-DS	Phase 3 Clinical	Isarna Therapeutics	Glioblastoma; Pancreatic Neoplasms; Coronavirus Disease 2019 (COVID-19); Colorectal Neoplasms; Astrocytoma; Melanoma	Details