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Brief Information

Name:Tumor necrosis factor receptor superfamily member 1B
Target Synonym:TNFR-II,TNFR80,TNF-RII,p80 TNF-alpha receptor,p75,Tumor necrosis factor receptor 2,Etanercept,TBP-2,Tumor necrosis factor receptor type II,TBPII,CD120b,TNF-R-II,CD120b Antigen,Tumor Necrosis Factor Beta Receptor,Soluble TNFR1B Variant 1,Tumor Necrosis Fac
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Part of Bioactivity data

Human TNFR2, His TagHuman TNFR2, His Tag (Cat. No. TN2-H5227) ELISA bioactivity

Immobilized ActiveMax® Human TNF-alpha, Tag Free, low endotoxin (Cat. No. TNA-H4211) at 5 μg/mL (100 μL/well) can bind Human TNFR2, His Tag (Cat. No. TN2-H5227) with a linear range of 5-39 ng/mL (QC tested).

Biotinylated Human TNFR2, His,Avitag™Biotinylated Human TNFR2, His,Avitag™ (Cat. No. TN2-H82E3) ELISA bioactivity

Immobilized Human TNF-alpha, His Tag (active trimer) (MALS verified) (Cat. No. TNA-H5228) at 5 μg/mL (100 μL/well) can bind Biotinylated Human TNFR2, His,Avitag™ (Cat. No. TN2-H82E3) with a linear range of 0.2-5 ng/mL (QC tested).

Synonym Name



TNF RI is also known as the p60 or p55 TNFR) and TNF RII (the p75 or p80 TNFR) are two distinct type I transmembrane glycoproteins that bind TNF with highaffinity.Both RI and RII are prototypic members of the TNF receptor superfamily and have been designated TNFRSF1A and TNFRSF1B, respectively. Human TNF RII cDNA encodes a 461 amino acid (aa) residue precursor protein with a 22 aa putative signal peptide, a 235 aa extracellular domain, a 20 aa transmembrane domain and a 174 aa cytoplasmic domain. TNFRII is expressed in fetal brain. The protein is produced naturally as a soluble form (sTNFRII). The soluble receptor inhibits TNFα action by competing with cell surface receptors in binding TNFα, thereby blocking its biologic effects. TNFRII is strongly expressed at the cartilage–pannus junction, and plays a major role in a subset of families with multiple cases of  rheumatoid arthritis (RA). Further, high plasma levels of sTNFRII were significantly associated with increased incidence of coronary heart disease, independent of established cardiovascular risk factors, and seems to be useful for monitoring the inflammatory activity of sarcoidosis.

Clinical and Translational Updates

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