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Osteoprotegerin

Osteoprotegerin Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
TNB-H5220 Human Human Osteoprotegerin / TNFRSF11B Protein, His Tag
TNB-H5220-structure
TNB-H5220-sds
TNB-H5220-elisa_1
TNB-H5259 Human Human Osteoprotegerin / TNFRSF11B Protein, Fc Tag
TNB-H5259-structure
TNB-H5259-sds
TNB-H5259-elisa_1

Osteoprotegerin Molecule Synonym Name

TNFRSF11B,OCIF,OPG,Osteoprotegerin

Osteoprotegerin Molecule Background

Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Osteoprotegerin References

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