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Your Position: Home > Carbonic Anhydrase IX

Carbonic Anhydrase IX

Brief Information

Name:Carbonic anhydrase IX
Target Synonym:EC:4.2.1.1,Renal cell carcinoma-associated antigen G250,P54/58N,CA9,Carbonic Anhydrase 9,RCC-Associated Protein G250,Carbonate Dehydratase IX,Carbonic Dehydratase,CA-IX,CAIX,PMW1,MN,EC 4.2.1.1,G250,Carbonic anhydrase IX,Membrane antigen MN,RCC-associated antigen G250
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

CA9-HP2H6-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

5e5 of anti-Carbonic Anhydrase IX CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human Carbonic Anhydrase IX (38-414), His Tag (Cat. No. CA9-HP2H6) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

CA9-H5253-ELISA
Human Carbonic Anhydrase IX (38-414), Fc TagHuman Carbonic Anhydrase IX (38-414), Fc Tag (Cat. No. CA9-H5253) ELISA bioactivity

Immobilized Human Carbonic Anhydrase IX / CA9 (38-414), Fc Tag (Cat. No. CA9-H5253) at 1 μg/mL (100 μL/well) can bind Anti-Carbonic Anhydrase IX Antibody, Human IgG1 with a linear range of 0.2-2 ng/mL (QC tested).

CA9-H82F5-MALS-HPLC
Biotinylated Human Carbonic Anhydrase IX (38-414), Fc,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human Carbonic Anhydrase IX (38-414), Fc,Avitag (Cat. No. CA9-H82F5) is more than 85% and the molecular weight of this protein is around 120-147 kDa verified by SEC-MALS.

Bioactivity-ELISA
Biotinylated Human Carbonic Anhydrase IX (38-414), Fc,AvitagBiotinylated Human Carbonic Anhydrase IX (38-414), Fc,Avitag (Cat. No. CA9-H82F5) ELISA bioactivity

Immobilized Biotinylated Human Carbonic Anhydrase IX (38-414), Fc,Avitag (Cat. No. CA9-H82F5) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-Carbonic Anhydrase IX Antibody, Human IgG1 with a linear range of 0.2-6 ng/mL (QC tested).

Synonym Name

CAIX,CA9,CA-IX,G250,MN,P54,58N,pMW1

Background

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes. CAs form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs rather slowly in the absence of a catalyst. One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. The active site of most carbonic anhydrases contains a zinc ion. There are at least five distinct CA families (α, β, γ, δ and ε). Carbonic anhydrase 9 (CA9 / CAIX) is also known as Membrane antigen MN (MN), Renal cell carcinoma-associated antigen G250, which belongs to the alpha-carbonic anhydrase family. CA9 / CAIX with an optimal activity at pH 6.49. Reversible hydration of carbon dioxide. CA IX participates in pH regulation. CA9 may be involved in the control of cell proliferation and transformation. CA-IX appears to be a novel specific biomarker for a cervical neoplasia.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Indium-111-DOTA-girentuximab-IRDye800CW (Radboud University) Phase 1 Clinical Radboud University Nijmegen Carcinoma, Renal Cell; Diagnostic agents Details
PMI-05 PMI-05 Phase 1 Clinical Precision Molecular Neoplasms Details
Sulfamide-nitroimidazole Clinical Dualtpharma Neoplasms Details
Lutetium-177 DOTA girentuximab TLX-250 Phase 2 Clinical Wilex, Heidelberg, Telix Pharmaceuticals Carcinoma, Renal Cell Details
Girentuximab-Zr-89 TLX250-CDx; 89Zr-TX250; TLX-250-CDx; 89Zr-TX-250 Phase 2 Clinical Wilex Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Urinary Bladder Neoplasms Details

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