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Carbonic Anhydrase IX

Carbonic Anhydrase IX Molecule Information

Name:Carbonic anhydrase IX
Target Synonym:Membrane antigen MN;CAIX;Carbonic anhydrase IX;P54/58N;pMW1;MN;Carbonate dehydratase IX;G250 ;Carbonic anhydrase 9;Renal cell carcinoma-associated antigen G250;RCC-associated antigen G250;CA9;CA-IX
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:11
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
CA9-H5220 Human Human Carbonic Anhydrase IX / CA9 (138-414) Protein, His Tag
CA9-H5226 Human Human Carbonic Anhydrase IX / CA9 (38-414) Protein, His Tag (active enzyme)

Carbonic Anhydrase IX Molecule Synonym Name


Carbonic Anhydrase IX Molecule Background

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes. CAs form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs rather slowly in the absence of a catalyst. One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. The active site of most carbonic anhydrases contains a zinc ion. There are at least five distinct CA families (¦Á, ¦Â, ¦Ã, ¦Ä and ¦Å). Carbonic anhydrase 9 (CA9 / CAIX) is also known as Membrane antigen MN (MN), Renal cell carcinoma-associated antigen G250, which belongs to the alpha-carbonic anhydrase family. CA9 / CAIX with an optimal activity at pH 6.49. Reversible hydration of carbon dioxide. CA IX participates in pH regulation. CA9 may be involved in the control of cell proliferation and transformation. CA-IX appears to be a novel specific biomarker for a cervical neoplasia.

Carbonic Anhydrase IX References

Carbonic Anhydrase IX Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PMI-05 PMI-05 Phase Ⅰ Precision Molecular Cancer Details
Monoclonal antibody G250RIT Phase Ⅱ Janssen, Wilex Renal carcinoma, Biliary cancer Details
Lutetium-177 DOTA girentuximab Phase Ⅱ Telix Pharmaceuticals, Wilex, Heidelberg Clear cell renal cell cancer (ccRCC) Details
Indium-111-DOTA-girentuximab-IRDye800CW (Radboud University) Phase Ⅰ Radboud University Renal cell carcinoma, Diagnostic agents Details
99mTc-MIP-1490 (Molecular Insight Pharmaceuticals) 99mTc-MIP-1490 Phase Not Specified Progenics Pharmaceutical Cancer Details
99mTc-MIP-1504 (Molecular Insight Pharmaceuticals) 99mTc-MIP-1504 Phase Not Specified Progenics Pharmaceutical Cancer Details
G250-scFV-transduced autologous T-lymphocyte cell therapy (Daniel den Hoed Cancer Center) Phase Ⅱ Erasmus University Renal cell carcinoma Details
[90Y]-DOTA-cG250 Phase Ⅰ Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center Renal carcinoma Details
Sulfamide-nitroimidazole Phase Not Specified DualTPharma Cancer Details
BAY 794620 Phase Ⅰ Bayer Solid tumours Details
DC-Ad-GMCAIX Phase Ⅰ University of California at Los Angeles, Kite Pharma Renal cell carcinoma Details
99mTc-MIP-1486 (Molecular Insight Pharmaceuticals) Phase Not Specified Progenics Pharmaceutical Cancer Details

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