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TRAIL R1

Brief Information

Name:Tumor necrosis factor receptor superfamily member 10A
Target Synonym:TRAIL-R1,Tumor necrosis factor receptor superfamily member 10A,DR4,TRAILR1,APO2,TNFRSF10A,TNF Receptor Superfamily Member 10a,Tumor Necrosis Factor Receptor Superfamily, Member 10a,Death Receptor 4,TRAIL Receptor 1,Cytotoxic TRAIL Receptor,CD261 Antigen,T
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Phase 3 Clinical

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By Product Category:
By Species:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
TR1-H5254 Human Human TRAIL R1 / DR4 / TNFRSF10A Protein, Fc Tag
TR1-H5254-structure
TR1-H5254-sds
TR1-H5254-elisa_1
TR1-H5228 Human Human TRAIL R1 / DR4 / TNFRSF10A Protein, His Tag
TR1-H5228-structure
TR1-H5228-sds
TR1-H5228-elisa_1

Part of Bioactivity data

TR1-H5254-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human TRAIL R1, Fc Tag (Cat. No. TR1-H5254) on AHC Biosensor, can bind Human TRAIL, His Tag with an affinity constant of 0.891 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

TR1-H5254-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human TRAIL, His Tag on HIS1K Biosensor, can bind Human TRAIL R1, Fc Tag (Cat. No. TR1-H5254) with an affinity constant of 2.4 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Customer Reviews

Synonym Name

TNFRSF10A,TRAIL-R1,CD261,APO2,DR4

Background

Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
HLX56 HLX56; HLX-56 Phase 1 Clinical Shanghai Henlius Biotech Co Ltd Solid tumours Details
Eftozanermin alfa APG-350; APG-880; ABBV-621; PR-1625011 Phase 1 Clinical Abbvie Inc Hematologic Neoplasms; Multiple Myeloma Details
Recombinant human tumor necrosis factor-related apoptosis-inducing ligand (Shenzhen Xinpeng Biotech) Phase 3 Clinical Shenzhen Xinpeng Biology Engineering Co Ltd Neoplasms Details
Circularly permuted TRAIL (Beijing Sunbio Biotech) Phase 3 Clinical Beijing Shadong Biotech Co Ltd Multiple Myeloma Details
Dulanermin (Shanghai GeBaiDe) Phase 3 Clinical Shanghai Gebaide Biotechnology Co Ltd Carcinoma, Non-Small-Cell Lung Details
Mapatumumab TRAIL-R1; DR4-mAB; HGS-1012; HGS-ETR1; TRM-1 Phase 2 Clinical Cambridge Antibody Technology Liver Neoplasms; Multiple Myeloma; Colorectal Neoplasms; Lymphoma, Non-Hodgkin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms Details

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