Transthyretin Protein - ACROBiosystems

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Transthyretin

Brief Information

Name:Transthyretin
Target Synonym:TTR,Transthyretin,Prealbumin, Amyloidosis Type I,PALB,ATTR,TBPA,Epididymis Luminal Protein 111,Thyroxine-Binding Prealbumin,Carpal Tunnel Syndrome 1,Prealbumin,HsT2651,HEL111,CTS1,CTS

Number of Launched Drugs:3
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Approved


TTR-H5223	Human	Human Transthyretin / Prealbumin Protein, His Tag

Cat. No.

Species

Product Description

Structure

Purity

Feature

TTR-H5223

Human

Human Transthyretin / Prealbumin Protein, His Tag

Synonym Name

Transthyretin,TTR,Prealbumin,TBPA,ATTR,PALB,CTS,CTS1,HsT2651

Background

Transthyretin (TTR) is also known as Prealbumin, ATTR, TBPA, PALB, which belongs to the transthyretin family. Transthyretin / TTR is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol. In cerebrospinal fluid TTR is the primary carrier of T4. TTR also acts as a carrier of retinol (vitamin A) through its association with retinol-binding protein (RBP) in the blood and the CSF. Less than 1% of TTR's T4 binding sites are occupied in blood. TTR misfolding and aggregation is known to be associated with the amyloid diseases.

Clinical and Translational Updates

Public Drug Information

Name	Research Code	Research Phase	Company	First Brand Name	First Approved Country	First Indication	First Approved Company	First Approved Date	Indications	Clinical Trials
Inotersen sodium	GSK-2998728; ISIS-420915	Approved	Ionis Pharmaceuticals Inc	Tegsedi	United States	Transthyretin amyloidosis	Akcea Therapeutics Inc	2018-07-05	Amyloid Neuropathies, Familial; Adenomatous Polyposis Coli; Amyloidosis; Transthyretin amyloidosis	Details
Patisiran	SAR-438037; GENZ-438027; ALN-TTR02; ALN-18328	Approved	Alnylam Pharmaceuticals Inc	Onpattro	Japan	Transthyretin amyloidosis	Alnylam Pharmaceuticals Inc	2018-08-10	Amyloid Neuropathies, Familial; Amyloidosis, Familial; Cardiomyopathies; Amyloidosis; Transthyretin amyloidosis; Amyloid Neuropathies	Details
Tafamidis Meglumine	PF-6291826; Fx-1006A; PF-06291826; FX-1006A	Approved	Pfizer Inc	维达全, Vyndaqel, Vyndamax, Vyndaqel/Vyndamax	Mainland China	Transthyretin amyloidosis; Amyloid Neuropathies	Pfizer Europe Ma Eeig	2011-11-16	Amyloid Neuropathies, Familial; Immunoglobulin Light-chain Amyloidosis; Heart Diseases; Cardiomyopathies; Amyloidosis; Transthyretin amyloidosis; Amyloid Neuropathies	Details

Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
PRX-004	PRX-004	Phase 1 Clinical	Prothena	Immunoglobulin Light-chain Amyloidosis; Transthyretin amyloidosis	Details
ION-682884	ION-682884; ION-TTR-LRx; AKCEA-TTR-LRx; IONIS-TTR-LRx	Phase 3 Clinical	Ionis Pharmaceuticals Inc	Amyloid Neuropathies, Familial; Transthyretin amyloidosis	Details
NI-006	NI-006	Phase 1 Clinical	Neurimmune	Cardiomyopathies; Transthyretin amyloidosis	Details
Acoramidis	BBP-265; AG-10; ALXN-2060	Phase 3 Clinical	Stanford University	Amyloidosis, Familial; Heart Diseases; Cardiomyopathies; Amyloidosis; Transthyretin amyloidosis; Amyloid Neuropathies	Details