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Your Position: Home > uPAR

uPAR

Brief Information

Name:Urokinase plasminogen activator surface receptor
Target Synonym:Monocyte activation antigen Mo3,U-PAR,uPAR,CD87,Urokinase-Type Plasminogen Activator (UPA) Receptor,URKR,U-Plasminogen Activator Receptor Form 2,CD87 Antigen,Plasminogen Activator, Urokinase Receptor,MO3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
UPR-M5253 Mouse Mouse uPAR / PLAUR Protein, Fc Tag (SPR verified)
UPR-M5253-structure
UPR-M5253-sds
UPR-R52H3 Rat Rat uPAR / PLAUR Protein, His Tag
UPR-R52H3-structure
UPR-R52H3-sds
UPR-C5253 Cynomolgus Cynomolgus uPAR / PLAUR Protein, Fc Tag (SPR verified)
UPR-C5253-structure
UPR-C5253-sds
CHEK-ATP151 Human HEK293/Human uPAR Stable Cell Line
SCCHO-ATP152 Human CHO/Human uPAR Stable Cell Line
UPR-HA2H9 Human APC-Labeled Human uPAR / PLAUR Protein, His Tag (Site-specific conjugation)
UPR-HA2H9-structure
UPR-M52H3 Mouse Mouse uPAR / PLAUR Protein, His Tag (SPR verified)
UPR-M52H3-structure
UPR-M52H3-sds
UPR-H52H4 Human Human uPAR / PLAUR (112-303) Protein, His Tag
UPR-H52H4-structure
UPR-H52H4-sds
UPR-H52H6 Human Human uPAR / PLAUR (209-303) Protein, His Tag
UPR-H52H6-structure
UPR-H52H6-sds
UPR-HP2H7 Human PE-Labeled Human uPAR / PLAUR Protein, His Tag (Site-specific conjugation)
UPR-HP2H7-structure
UPR-H5254 Human Human uPAR / PLAUR Protein, Fc Tag (MALS verified)
UPR-H5254-structure
UPR-H5254-sds
UPR-HF2H3 Human FITC-Labeled Human uPAR / PLAUR Protein, His Tag
UPR-HF2H3-structure
UPR-HF2H3-sds
UPR-H82E7 Human Biotinylated Human uPAR / PLAUR Protein, His,Avitag™ (MALS verified)
UPR-H82E7-structure
UPR-H82E7-sds
UPR-H5226 Human Human uPAR / PLAUR Protein, His Tag (MALS verified)
UPR-H5226-structure
UPR-H5226-sds
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Part of Bioactivity data

CHEK-ATP151-Cell-based assay
uPAR FACS

Expression analysis of human uPAR on HEK293/Human uPAR Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human uPAR Stable Cell Line or negative control cell using PE-labeled anti-human uPAR antibody.

Protocol
SCCHO-ATP152-Cell-based assay
uPAR FACS

Expression analysis of human uPAR on CHO/Human uPAR Stable Cell Line by FACS.
Cell surface staining was performed on CHO/Human uPAR Stable Cell Line or negative control cell using PE-labeled anti-human uPAR antibody.

Protocol
UPR-M5253-SPR
uPAR SPR

Human PLAU, His Tag (Cat. No. PLU-H5229) capture on NTA-Series S sensor chip can bind Mouse uPAR Protein, Fc Tag (Cat. No. UPR-M5253) with an affinity constant of 182 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
UPR-C5253-SPR
uPAR SPR

Cynomolgus uPAR Protein, Fc Tag (Cat. No. UPR-C5253) immobilized on CM5 Chip can bind Human PLAU, His Tag (Cat. No. PLU-H5229) with an affinity constant of 44.1 pM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol

Synonym Name

uPAR,PLAUR,CD87,MO3

Background

Urokinase plasminogen activator surface receptor (U-PAR) is also known as PLAUR, Monocyte activation antigen Mo3, CD antigen CD87. PLAUR contains three UPAR/Ly6 domains. U-PAR is expressed in neurons of the rolandic area of the brain (at protein level) and is also expressed in the brain. PLAUR / CD87 interacts with MRC2, SRPX2 and SORL1. PLAUR / UPAR acts as a receptor for urokinase plasminogen activator and plays a role in localizing and promoting plasmin formation. U-PAR mediates the proteolysis-independent signal transduction activation effects of U-PA.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Gallium-68 NOTA AE105 (Curasight) CS-001; 68Ga-NOTA-AE105 Phase 3 Clinical Rigshospitalet, Curasight Aps Head and Neck Neoplasms; Bone metastases; Neoplasms; Glioblastoma; Neuroendocrine Tumors; Urinary Bladder Neoplasms; Mesothelioma; Breast Neoplasms; Prostatic Neoplasms; Oropharyngeal Neoplasms; Genital Neoplasms, Female; Mouth Neoplasms; Hair Diseases; Carcinoma, Non-Small-Cell Lung Details
WAL0921 WAL0921; WAL-0921; WAL 0921 Phase 2 Clinical Walden Biosciences Inc Glomerulonephritis, IGA; Kidney Diseases; Nephrosis, Lipoid; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Segmental; Diabetic Nephropathies; Renal Insufficiency, Chronic Details
64Cu-DOTA-AE105 64Cu-DOTA-AE105 Phase 2 Clinical Rigshospitalet Urinary Bladder Neoplasms; Prostatic Neoplasms; Breast Neoplasms Details
FG-001 FG001; FG-001 Phase 2 Clinical FluoGuide AS Head and Neck Neoplasms; Brain Neoplasms; Glioma; Lung Neoplasms; Meningioma Details
MNPR-101-Lu177 MNPR-101-Lu177; MNPR-101-PCTA-177Lu Phase 1 Clinical Monopar Therapeutics Inc Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Urinary Bladder Neoplasms; Colorectal Neoplasms; Lung Neoplasms Details
MNPR-101-Zr MNPR-101-Zr; MNPR-101-DFO*-89Zr Phase 1 Clinical Monopar Therapeutics Inc, Northstar Medical Radioisotopes Llc Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Triple Negative Breast Neoplasms; Neoplasms; Urinary Bladder Neoplasms; Colorectal Neoplasms; Lung Neoplasms Details
KMHH-03 KMHH-03; KMHH03 Phase 1 Clinical Beijing Kangming Haihui Biological Technology Co Ltd Breast Neoplasms Details

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