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Thrombopoietin

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Cat. No. Species Product Description Structure Purity Feature
THN-H5214 Human Human Thrombopoietin / TPO Protein, Tag Free (MALS verified)
THN-H5214-structure
THN-H5214-sds
THN-H5214-elisa_2

Part of Bioactivity data

THN-H5214-BLI
Human_FcRn_Heterodimer_Protein_SPR

Human Thrombopoietin R, His Tag (Cat. No. THR-H52H7) captured on CM5 Chip via anti-His antibody can bind Human Thrombopoietin, Tag Free (Cat. No. THN-H5214) with an affinity constant of 14.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Synonym Name

Thrombopoietin,MKCSF,THPO,TPO,C-mpl ligand,MGDF

Background

Thrombopoietin (TPO) is a 332 amino acid glycoprotein made primarily in the liver and act as the major physiological regulator of platelet production. TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production. Additionally, further investigation uncovered that thrombopoietin is a critical cytokine promoting hematopoietic rebound after myeloablation and its transcripts are expressed by multiple cellular sources.

Clinical and Translational Updates

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