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Your Position: Home > Thrombopoietin

Thrombopoietin

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Cat. No.	Species	Product Description	Structure	Purity	Feature
THN-H5214	Human	Human Thrombopoietin / TPO Protein, premium grade

ACRO Quality

Part of Bioactivity data

THN-H5214-BLI

Thrombopoietin SPR

Human Thrombopoietin R, His Tag (Cat. No. THR-H52H7) captured on CM5 Chip via anti-His antibody can bind Human Thrombopoietin, premium grade (Cat. No. THN-H5214) with an affinity constant of 14.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Synonym Name

Thrombopoietin,MKCSF,THPO,TPO,C-mpl ligand,MGDF

Background

Thrombopoietin (TPO) is a 332 amino acid glycoprotein made primarily in the liver and act as the major physiological regulator of platelet production. TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production. Additionally, further investigation uncovered that thrombopoietin is a critical cytokine promoting hematopoietic rebound after myeloablation and its transcripts are expressed by multiple cellular sources.

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