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Thrombopoietin

Brief Information

Name:Thrombopoietin
Target Synonym:Prepro-Thrombopoietin,MPL Ligand,MGDF,THCYT1,MKCSF,MPLLG,TPO,Thrombopoietin,THPO,Megakaryocyte colony-stimulating factor,Megakaryocyte growth and development factor,C-mpl ligand,ML,Myeloproliferative Leukemia Virus Oncogene Ligand,Megakaryocyte Stimulating Factor,Thrombopoietin Nirs Variant 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Discontinued

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Cat. No. Species Product Description Structure Purity Feature
GMP-THNH25 Human GMP Human Thrombopoietin Protein
GMP-THNH25-structure
THN-H5214 Human Human Thrombopoietin / TPO Protein, premium grade
THN-H5214-structure
THN-H5214-sds
ACRO Quality

Part of Bioactivity data

THN-H5214-Cell-based assay
 Thrombopoietin CELL

Human Thrombopoietin, premium grade (Cat. No. THN-H5214) stimulates proliferation of Mo7e cells. The specific activity of Human Thrombopoietin, premium grade is > 1.0ⅹ10^7 IU/mg (Routinely tested).

THN-H5214-BLI
 Thrombopoietin SPR

Human Thrombopoietin R, His Tag (Cat. No. THR-H52H7) captured on CM5 Chip via anti-His antibody can bind Human Thrombopoietin, premium grade (Cat. No. THN-H5214) with an affinity constant of 14.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Synonym Name

Thrombopoietin,MKCSF,THPO,TPO,C-mpl ligand,MGDF

Background

Thrombopoietin (TPO) is a 332 amino acid glycoprotein made primarily in the liver and act as the major physiological regulator of platelet production. TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production. Additionally, further investigation uncovered that thrombopoietin is a critical cytokine promoting hematopoietic rebound after myeloablation and its transcripts are expressed by multiple cellular sources.

Clinical and Translational Updates

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