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Your Position: Home > CD117

CD117

Brief Information

Name:Stem cell growth factor receptor
Target Synonym:EC 2.7.10,EC:2.7.10.1,MASTC,KIT Proto-Oncogene Receptor Tyrosine Kinase,V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene-Like Protein,p145 c-kit,SCFR,KIT,Proto-Oncogene C-Kit,Proto-Oncogene Tyrosine-Protein Kinase Kit,Soluble KIT Variant 1,C-Kit Protooncogene,CD117 Antigen,Piebald Trait,EC 2.7.10.1,C-Kit,CD117,Proto-Oncogene Proteins c-kit,Mast/stem cell growth factor receptor Kit,PBT,Piebald trait protein,Tyrosine-protein kinase Kit,KIT Proto-Oncogene, Receptor Tyrosine Kinase,v-kit Hardy-
Number of Launched Drugs:15
Number of Drugs in Clinical Trials:17
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CD7-C52H9 Cynomolgus Cynomolgus CD117 / c-kit Protein, His Tag (MALS verified)
CD7-C52H9-structure
CD7-C52H9-sds
CD7-H82E6 Human Biotinylated Human CD117 / c-kit Protein, His,Avitag (MALS verified)
CD7-H82E6-structure
CD7-H82E6-sds
CD7-R5259 Rhesus macaque Rhesus macaque CD117 / c-kit Protein, Fc Tag (MALS verified)
CD7-R5259-structure
CD7-R5259-sds
CD7-M5259 Mouse Mouse CD117 / c-kit Protein, Fc Tag (MALS verified)
CD7-M5259-structure
CD7-M5259-sds
CD7-H5255 Human Human CD117 / c-kit Protein, Fc Tag (MALS verified)
CD7-H5255-structure
CD7-H5255-sds
CD7-H52H4 Human Human CD117 / c-kit Protein, His Tag (MALS verified)
CD7-H52H4-structure
CD7-H52H4-sds

Part of Bioactivity data

CD7-H82E6-ELISA
Biotinylated Human CD117, His,AvitagBiotinylated Human CD117, His,Avitag (Cat. No. CD7-H82E6) ELISA bioactivity

Immobilized ActiveMax® Human SCF, His Tag (Cat. No. SCF-H4219) at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD117, His,Avitag (Cat. No. CD7-H82E6) with a linear range of 0.02-0.625 μg/mL (QC tested).

Protocol
CD7-C52H9-MALS-HPLC
Cynomolgus CD117, His Tag (Cat. No. ) MALS images

The purity of Cynomolgus CD117, His Tag (Cat. No. CD7-C52H9) is more than 90% and the molecular weight of this protein is around 68-88 kDa verified by SEC-MALS.

Report
Bioactivity-ELISA
Cynomolgus CD117, His TagCynomolgus CD117, His Tag (Cat. No. CD7-C52H9) ELISA bioactivity

Immobilized Cynomolgus CD117, His Tag (Cat. No. CD7-C52H9) at 2 μg/mL (100 μL/well) can bind Biotinylated Human SCF, Avitag,His Tag (Cat. No. SCF-H82E1) with a linear range of 0.2-5 ng/mL (QC tested).

Customer Reviews

Synonym Name

CD117,SCFR,c-Kit,KIT

Background

Mast/stem cell growth factor receptor Kit (c-Kit), a member of  the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily, is also known as piebald trait protein (PBT), p145 c-kit, tyrosine-protein kinase Kit and CD117,which contains five Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. CD117 acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, CD117 can activate several signaling pathways. Furthermore, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B.

Clinical and Translational Updates

Related Molecule

SCF

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Midostaurin PKC-412; PKC-412A; CGP-41231; CGP-41251 Approved Novartis Pharma Ag Rydapt EU Leukemia, Myeloid, Acute; Mastocytosis Novartis Europharm Ltd 2017-04-28 Leukemia; Hematologic Neoplasms; Mastocytosis, Systemic; Leukemia, Mast-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Mastocytosis Details
Ancestim AMJ-9302 Approved Amgen Inc Stemgen Hematopoietic stem cell transplantation (HSCT) Details
Imatinib mesylate CGP-57148B; CGP-57148; STI-571; QTI-571; CTI-571; AER-901; VR325 Approved Novartis Pharma Ag glivic, 格列卫, Gleevec, Ruvise, Glivec, Gleevec/Glivec United States Precursor Cell Lymphoblastic Leukemia-Lymphoma Novartis Pharma Ag 2001-05-10 Chronic eosinophilic leukemia (CEL); Prostatic Diseases; Myelodysplastic-Myeloproliferative Diseases; Acute Lung Injury; Leukemia, Myeloid, Acute; Urogenital Neoplasms; Pulmonary Edema; Philadelphia Chromosome; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Chronic-Phase; Neurofibrosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Pulmonary Arterial Hypertension; Chordoma; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Respiratory Distress Syndrome, Adult; Leukemia, Myelomonocytic, Chronic; Glioblastoma; Dermatofibrosarcoma; Mastocytosis, Systemic; Myelodysplastic Syndromes; Coronavirus Disease 2019 (COVID-19); Rhinitis, Allergic, Seasonal; Genital Neoplasms, Male; Abdominal Neoplasms; Leukemia; Genital Diseases, Male; Hypereosinophilic Syndrome Details
Pexidartinib PLX-3397 Approved Daiichi Sankyo Co Ltd Turalio United States Giant Cell Tumor of Tendon Sheath Daiichi Sankyo Inc 2019-08-02 Giant Cell Tumor of Tendon Sheath; Solid tumours; Synovitis, Pigmented Villonodular; Hodgkin Disease; Arthritis, Rheumatoid; Glioblastoma; Giant Cell Tumors; Prostatic Neoplasms; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute Details
Cabozantinib S-malate XL-184; BMS-907351 Approved Exelixis Inc Cometriq, Cabometyx Japan Carcinoma, Renal Cell Takeda 2012-11-29 Solid tumours; Carcinoma, Renal Cell; Stomach Neoplasms; Pain; Esophageal Neoplasms; Glioblastoma; Kidney Diseases; Prostatic Neoplasms; Colorectal Neoplasms; Astrocytoma; Hepatic Insufficiency; Thyroid Neoplasms; Carcinoma, Neuroendocrine; Lymphoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
Avapritinib BLU-285; CS-3007 Approved Blueprint Medicines Corp Ayvakit, Ayvakyt, 泰吉华 Hong Kong Gastrointestinal Stromal Tumors Cstone Pharmaceuticals 2020-01-09 Solid tumours; Hematologic Neoplasms; Mastocytosis, Systemic; Leukemia, Mast-Cell; Central Nervous System Neoplasms; Gastrointestinal Stromal Tumors Details
Pazopanib Hydrochloride GW-786034; SB-786034; GSK-786034; GW-786034B Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Patorma, Votrient Mainland China Carcinoma, Renal Cell Novartis Pharma Schweiz Ag 2009-10-19 Osteosarcoma; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Melanoma; Carcinoma, Hepatocellular; Fallopian Tube Neoplasms; Glioma; Peritoneal Neoplasms; Colorectal Neoplasms; Prostatic Neoplasms; Ovarian Neoplasms; Breast Neoplasms; Sarcoma; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Hemangiosarcoma; Carcinoma, Renal Cell; Solid tumours; Chondrosarcoma; Telangiectasia, Hereditary Hemorrhagic Details
Ripretinib DCC-2618 Approved Deciphera Qinlock, 擎乐 United Kingdom Gastrointestinal Stromal Tumors Deciphera Pharmaceuticals Llc 2020-05-15 Mastocytosis, Systemic; Gastrointestinal Stromal Tumors Details
Ponatinib Hydrochloride AP-24534; INCB-84344; AP24534 HCl; AP24534-HCL; AP24534 hydrochloride Approved Ariad Iclusig Japan Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic, BCR-ABL Positive Otsuka Holdings Co Ltd 2012-12-14 Leukemia; Leukemia, Myeloid, Accelerated Phase; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Solid tumours; Hematologic Neoplasms; Blast Crisis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Philadelphia Chromosome; Leukemia, Myeloid, Chronic-Phase; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute; Lymphoma; Leukemia, Biphenotypic, Acute Details
Regorafenib DAST; BAY-73-4506 Approved Bayer Ag Resihance, Stivarga Mainland China Gastrointestinal Stromal Tumors Bayer Pharma Ag 2012-09-27 Solid tumours; Carcinoma, Renal Cell; Rectal Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Carcinoma, Hepatocellular; Gastrointestinal Neoplasms Details
Lenvatinib Mesylate MK-7902; ER-203492-00; E-7080 Approved Eisai Co Ltd Kisplyx, Lenvima, Lenvima/Kisplyx, 乐卫玛 Japan Endometrial Neoplasms Eisai Co Ltd 2015-02-13 Liver Diseases; Carcinoma, Non-Small-Cell Lung; Melanoma; Carcinoma, Hepatocellular; Lymphoma; Thyroid Neoplasms; Endometrial Neoplasms; Hepatic Insufficiency; Sarcoma; Urinary Bladder Neoplasms; Solid tumours; Adenocarcinoma of Lung; Thyroid Carcinoma, Anaplastic; Kidney Diseases; Small Cell Lung Carcinoma; Squamous Cell Carcinoma of Head and Neck; Renal Insufficiency; Carcinoma, Renal Cell; Liver Neoplasms; Biliary Tract Neoplasms Details
Olverembatinib D-824; GZD-824; APG-1351; GIBH-824; HQP-1351 Approved Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences 耐立克 Mainland China Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Accelerated Phase Guangzhou Shunjian Biomedical Technology Co Ltd 2021-11-25 Solid tumours; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Accelerated Phase; Leukemia, Myeloid; Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Gastrointestinal Stromal Tumors Details
Anlotinib Dihydrochloride AL-3818 Approved Advenchen Laboratories, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 福可维 Mainland China Small Cell Lung Carcinoma Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 2018-05-08 Endometrial Neoplasms; Cholangiocarcinoma; Nasopharyngeal Carcinoma; Urologic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Bone Neoplasms; Sarcoma, Alveolar Soft Part; Gallbladder Neoplasms; Medullary thyroid cancer (MTC); Thyroid Neoplasms; Esophageal Squamous Cell Carcinoma; Lung Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Melanoma; Osteoma; Carcinoma, Renal Cell; Head and Neck Neoplasms; Solid tumours; Biliary Tract Neoplasms; Ovarian Neoplasms; Thoracic Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Genital Diseases, Female; Leiomyosarcoma; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Lymphoma, Large B-Cell, Diffuse; Sarcoma, Synovial; Neuroendocrine Tumors; Sarcoma; Bile Duct Diseases Details
Sorafenib Tosylate NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085 Approved Onyx Pharmaceuticals Inc 多吉美, Nexavar EU Thyroid Neoplasms Bayer Ag 2005-12-01 Breast Neoplasms; Neoplasm Metastasis; Fasting; Melanoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Thyroid Neoplasms; Hepatitis C; Hepatitis B; Liver Neoplasms; Liver Diseases; Pancreatic Neoplasms; Kidney Diseases; Carcinoma; Carcinoma, Renal Cell; Kidney Neoplasms; Solid tumours; Ovarian Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive Details
Dasatinib Hydrate BMS-354825; NSC-732517 Approved Bristol-Myers Squibb Company 施达赛, Spricel, Sprycel, Spraysel Mainland China Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic, BCR-ABL Positive Bristol-Myers Squibb Pharma Eeig 2006-06-28 Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia; Leukemia, Myeloid, Accelerated Phase; Leukemia, Myeloid; Leukemia, Lymphoid; Myelodysplastic Syndromes; Scleroderma, Systemic; Blast Crisis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Breast Neoplasms; Leukemia, Myeloid, Chronic-Phase; Leukemia, Myeloid, Acute; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
Sunitinib Malate PHA-290940; SU-010398; SU-11248; GB-102; PNU-290940; SU-011248-L-malate salt; PNU-290940AD; PHA-290940AD Approved Pfizer Pharmaceuticals Ltd (China) Sutent, 索坦 Japan Pancreatic neuroendocrine tumors (pNET) Pfizer Inc 2006-01-26 Breast Neoplasms; Retinal Vein Occlusion; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Macular Degeneration; Carcinoma, Hepatocellular; Urogenital Neoplasms; Urologic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Diabetic macular oedema; Prostatic Neoplasms; Kidney Neoplasms; Neuroendocrine Tumors; Urologic Diseases; Kidney Diseases; Pancreatic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Stomach Neoplasms; Carcinoma, Islet Cell; Carcinoma, Renal Cell; Liver Neoplasms; Solid tumours Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Telatinib EOC-315; BAY-57-9352 Phase 2 Clinical Bayer Ag Solid tumours; Stomach Neoplasms Details
Hydroxychloroquine/Sorafenib Phase 1 Clinical Vg Life Sciences Ovarian Neoplasms Details
QBH-196 QBH-196 Phase 1 Clinical Shenyang Pharmaceutical University Solid tumours; Stomach Neoplasms Details
Tafetinib Malate SIM-0702; SIM-1005; SIM-010603 Phase 1 Clinical Jiangsu Xiansheng Pharmaceutical Co Ltd, Nanjing Yoko Biomedical Co Ltd, Jilin Boda Pharmaceutical Co Ltd Solid tumours; Neoplasms Details
GS-0174 GS-0174 Phase 1 Clinical Forty Seven Hematologic Neoplasms Details
Imatinib mesylate (YD Global Life Science) YD-312 Phase 2 Clinical Yd Global Life Science Diabetic macular oedema Details
NMS-03592088 NMS-P088; NMS-03592088 Phase 2 Clinical Nerviano Medical Sciences Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
JSP-191 AMG-191; JSP-191 Phase 2 Clinical Amgen Inc Myelodysplastic Syndromes; Severe Combined Immunodeficiency; Leukemia, Myeloid, Acute; Inflammation Details
Imatinib dry powder inhalation (Aerovate Therapeutics) AV-101 - Aerovate Therapeutics Phase 3 Clinical Pulmonary Arterial Hypertension Details
Barzolvolimab CDX-0159 Phase 1 Clinical Yale University, University Of Toronto - St. George Campus Chronic Urticaria; Skin Diseases; Urticaria; Prurigo Details
T-1301 T-1301; DBPR-216 Phase 1 Clinical Taivex Therapeutics Corp Solid tumours; Lymphoma Details
THE-630 THE-630 Phase 2 Clinical Theseus Pharmaceuticals Inc Gastrointestinal Diseases; Neoplasms, Connective and Soft Tissue; Digestive System Neoplasms; Gastrointestinal Stromal Tumors; Neoplasms, Connective Tissue; Gastrointestinal Neoplasms Details
PLX-9486 PLX-9486 Phase 3 Clinical Daiichi Sankyo Co Ltd Hematologic Neoplasms; Mastocytosis, Systemic; Leukemia, Mast-Cell; Gastrointestinal Stromal Tumors; Mastocytosis; Neoplasm Metastasis Details
MGTA-117 MGTA-117 Phase 2 Clinical Heidelberg, Magenta Therapeutics Inc Myelodysplastic Syndromes; Metabolic Diseases; Leukemia, Myeloid, Acute; Anemia, Sickle Cell Details
Masitinib mesylate AB-1010; AB19001 Phase 3 Clinical Ab Science Prostatic Neoplasms; Melanoma; Mastocytosis; Amyotrophic Lateral Sclerosis; Alzheimer Disease; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Asthma; Psoriasis; Ovarian Neoplasms; Multiple Sclerosis; Multiple Myeloma; Multiple Sclerosis, Chronic Progressive; Coronavirus Disease 2019 (COVID-19); Mastocytosis, Systemic; Arthritis, Rheumatoid; Pancreatic Neoplasms Details
MG-D-1609 MG-D-1609 Phase 2 Clinical Metagone Biotech Solid tumours Details
Sorafenib/MG-005 MGD-1509; MG-D-1509 Phase 1 Clinical Metagone Biotech, Tri-Service General Hospital Solid tumours Details

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