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Brief Information

Name:Stem cell growth factor receptor
Target Synonym:EC 2.7.10,EC:,MASTC,KIT Proto-Oncogene Receptor Tyrosine Kinase,V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene-Like Protein,p145 c-kit,SCFR,KIT,Proto-Oncogene C-Kit,Proto-Oncogene Tyrosine-Protein Kinase Kit,Soluble KIT Variant 1,C-Kit Protooncogene,CD117 Antigen,Piebald Trait,EC,C-Kit,CD117,Proto-Oncogene Proteins c-kit,Mast/stem cell growth factor receptor Kit,PBT,Piebald trait protein,Tyrosine-protein kinase Kit,KIT Proto-Oncogene, Receptor Tyrosine Kinase,v-kit Hardy-
Number of Launched Drugs:16
Number of Drugs in Clinical Trials:24
Lastest Research Phase:Approved

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Part of Bioactivity data


Immobilized Human SCF protein, His Tag at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD117, His,Avitag (Cat. No. CD7-H82E6) with a linear range of 0.02-0.625 μg/mL (QC tested).

CD117 MALS images

The purity of Cynomolgus CD117, His Tag (Cat. No. CD7-C52H9) is more than 90% and the molecular weight of this protein is around 68-88 kDa verified by SEC-MALS.

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Synonym Name



Mast/stem cell growth factor receptor Kit (c-Kit), a member of  the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily, is also known as piebald trait protein (PBT), p145 c-kit, tyrosine-protein kinase Kit and CD117,which contains five Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. CD117 acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, CD117 can activate several signaling pathways. Furthermore, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B.

Clinical and Translational Updates

Related Molecule


Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Midostaurin PKC-412; PKC-412A; CGP-41231; CGP-41251 Approved Novartis Pharma Ag Rydapt United States Mastocytosis, Systemic; Leukemia, Mast-Cell; Hematologic Neoplasms; Leukemia, Myeloid, Acute Novartis Pharmaceuticals Corp 2017-04-28 Leukemia; Hematologic Neoplasms; Mastocytosis, Systemic; Myelodysplastic Syndromes; Leukemia, Mast-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Mastocytosis Details
Sunitinib Malate PHA-290940; SU-010398; SU-11248; GB-102; PNU-290940; SU-011248-L-malate salt; PNU-290940AD; PHA-290940AD; SCAI-003 Approved Pfizer Pharmaceuticals Ltd (China) Sutent, 索坦 United States Gastrointestinal Stromal Tumors; Carcinoma, Renal Cell Cppi Cv 2006-01-26 Solid tumours; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Leiomyosarcoma; Fibrosarcoma; Leukemia; Kidney Neoplasms; Teratoma; Head and Neck Neoplasms; HIV Infections; Intestinal Neoplasms; Ovarian Neoplasms; Ependymoma; Leukemia, Myeloid, Accelerated Phase; Fibromatosis, Aggressive; Liver Neoplasms; Lymphoma, T-Cell, Peripheral; Leukemia, Myelogenous, Chronic; Carcinoma, Renal Cell; Pheochromocytoma; Histiocytoma, Malignant Fibrous; Thoracic Neoplasms; Hemangioblastoma; Leukemia, Hairy Cell; Abdominal Neoplasms; Stomach Neoplasms; Carcinoma, Islet Cell; Polycythemia Vera; Esophageal Neoplasms; Carcinoma; Pelvic Neoplasms; Squamous Cell Carcinoma of Head and Neck; Glioblastoma; Myelodysplastic Syndromes; Carcinoma, Papillary; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Leukemia, Myelomonocytic, Chronic; Neurofibromatoses; Pancreatic neuroendocrine tumors (pNET); Neoplasms; Adenoma, Islet Cell; Myeloproliferative Disorders; Pancreatic Neoplasms; Plasmacytoma; Carcinoma, Transitional Cell; Immunogl Details
Imatinib mesylate CGP-57148B; QTI-571; CTI-571; VR325; CGP-57148; STI-571; AER-901; TNX-201; YD-312 Approved Novartis Pharma Ag glivic, 格列卫, Gleevec, Ruvise, Glivec, Gleevec/Glivec EU Leukemia, Myelogenous, Chronic Novartis Europharm Ltd 2001-05-10 Leukemia; Ovarian Neoplasms; Hypertension, Pulmonary; Leukemia, Myelogenous, Chronic; Neoplasm, Residual; Hypereosinophilic Syndrome; Solid tumours; Hematopoietic stem cell transplantation (HSCT); Genital Diseases, Male; Diabetes Mellitus, Type 1; Leukemia, Myeloid, Accelerated Phase; Head and Neck Neoplasms; Ovarian germ cell tumor; Fibrosarcoma; Lymphoma, B-Cell, Marginal Zone; Loiasis; Abdominal Neoplasms; Genital Neoplasms, Male; Rhinitis, Allergic, Seasonal; Polycythemia Vera; Histiocytoma, Malignant Fibrous; Leukemia, Hairy Cell; Desmoplastic Small Round Cell Tumor; Rectal Neoplasms; Stomach Neoplasms; Macular Edema; Skin Neoplasms; Neurofibromatoses; Coronavirus Disease 2019 (COVID-19); Scleroderma, Systemic; Neoplasms; Mastocytosis, Systemic; Dermatofibrosarcoma; Myeloproliferative Disorders; Leukemia, Myelomonocytic, Chronic; Idiopathic Pulmonary Fibrosis; Graft vs Host Disease; Glioblastoma; Myelodysplastic Syndromes; Leukemia-Lymphoma, Adult T-Cell; Eosinophilia; Plasmacytoma; Small Cell Lung Carci Details
Dasatinib Hydrate BMS-354825; XS-004; NSC-732517 Approved Bristol-Myers Squibb Company Dasynoc, Spricel, Sprycel, Spraysel, 施达赛 United States Leukemia, Myelogenous, Chronic; Precursor Cell Lymphoblastic Leukemia-Lymphoma Bristol-Myers Squibb Company 2006-06-28 Gliosarcoma; Intraocular Lymphoma; Neoplasms, Gonadal Tissue; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Carcinoma, Squamous Cell; Lymphoma; Giant Cell Tumor of Bone; Gastrointestinal Stromal Tumors; Peritoneal Neoplasms; Primary Myelofibrosis; Astrocytoma; Waldenstrom Macroglobulinemia; Leukemia, Myeloid, Chronic-Phase; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Neurofibrosarcoma; Lymphoma, Mantle-Cell; Lymphoma, Follicular; Sarcoma; Cholangiocarcinoma; Sarcoma, Ewing; Prostatic Neoplasms; Breast Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Leukemia, Large Granular Lymphocytic; Leukemia, T-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Adenocarcinoma; Mastocytosis; Mycosis Fungoides; Tongue Neoplasms; Melanoma; Heart Arrest; Neoplasm Metastasis; Brain Neoplasms; Lymphoma, T-Cell, Cutaneous; Burkitt Lymphoma; Hemangiopericytoma; Uterine Neoplasms; Fallopian Tube Neoplasms; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell; S Details
Cabozantinib S-malate XL-184; BMS-907351 Approved Exelixis Inc Cometriq, Cabometyx United States Carcinoma, Neuroendocrine; Thyroid Neoplasms Exelixis Inc 2012-11-29 Carcinoma, Adenosquamous; Uterine Neoplasms; Thyroid Neoplasms; Hepatic Insufficiency; Gliosarcoma; Bile Duct Neoplasms; Peritoneal Neoplasms; Astrocytoma; Colorectal Neoplasms; Brain Neoplasms; Endometrial Neoplasms; Osteosarcoma; Urethral Neoplasms; Adenocarcinoma, Clear Cell; Neuroblastoma; Neurofibroma, Plexiform; Cholangiocarcinoma; Medullary thyroid cancer (MTC); Sarcoma, Ewing; Breast Neoplasms; Carcinoma, Endometrioid; Neoplasms, Germ Cell and Embryonal; Meningioma; Melanoma; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Thyroid Cancer, Papillary; Neoplasm Metastasis; Paraganglioma; Carcinoma, Hepatocellular; Sarcoma, Clear Cell; Carcinoma, Neuroendocrine; Fallopian Tube Neoplasms; Brain metastases; Lymphoma; Leukemia, Myeloid, Acute; Sarcoma, Alveolar Soft Part; Glioma; Carcinoma, Squamous Cell; Pain; Adrenal Cortex Neoplasms; Pancreatic neuroendocrine tumors (pNET); Glioblastoma; Kidney Diseases; Hepatoblastoma; Pheochromocytoma; Carcinoma, Renal Cell; Rejection of liver transplantation; Carcinoid Details
Pexidartinib PLX-3397 Approved Daiichi Sankyo Co Ltd Turalio United States Giant Cell Tumor of Tendon Sheath Daiichi Sankyo Inc 2019-08-02 Neurofibrosarcoma; Carcinoma, Non-Small-Cell Lung; Melanoma; Neoplasm Metastasis; Leukemia, Myeloid, Acute; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Giant Cell Tumors; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Neurofibroma, Plexiform; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Sarcoma; Solid tumours; Breast Neoplasms; Neoplasms; Arthritis, Rheumatoid; Hodgkin Disease; Glioblastoma; Pancreatic Neoplasms; Synovitis, Pigmented Villonodular; Squamous Cell Carcinoma of Head and Neck; Leukemia, Promyelocytic, Acute; Ovarian Neoplasms; Giant Cell Tumor of Tendon Sheath Details
Vorolanib X-82; EYP-1901; CM-082 Approved Tyrogenex Inc 伏美纳 Mainland China Carcinoma, Renal Cell Betta Pharmaceuticals Co Ltd 2023-06-07 Diabetic macular oedema; Diabetic Retinopathy; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Melanoma; Macular Degeneration; Choroidal Neovascularization; Adenocarcinoma; Leukemia, Myeloid, Acute; Retinal Degeneration; Eye Diseases; Solid tumours; Wet Macular Degeneration; Retinal Diseases; Small Cell Lung Carcinoma; Neoplasms; Pancreatic Neoplasms; Esophageal Neoplasms; Carcinoma, Renal Cell; Stomach Neoplasms; Kidney Neoplasms Details
Avapritinib BLU-285; CS-3007 Approved Blueprint Medicines Corp Ayvakyt, Ayvakit, 泰吉华 United States Gastrointestinal Stromal Tumors Blueprint Medicines Corp 2020-01-09 Solid tumours; Hematologic Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Mastocytosis, Systemic; Central Nervous System Neoplasms; Leukemia, Mast-Cell; Sarcoma; Breast Neoplasms; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Lung Neoplasms; Melanoma; Adenocarcinoma Details
Anlotinib Dihydrochloride AL-3818 Approved Advenchen Laboratories Llc, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 福可维 Mainland China Carcinoma, Non-Small-Cell Lung Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 2018-05-08 Glioma; Bile Duct Diseases; Peritoneal Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Bone Neoplasms; Urologic Neoplasms; Hepatic Insufficiency; Thyroid Neoplasms; Sarcoma, Alveolar Soft Part; Fallopian Tube Neoplasms; Nasopharyngeal Carcinoma; Lung Neoplasms; Esophageal Squamous Cell Carcinoma; Endometrial Neoplasms; Gallbladder Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms; Osteoma; Melanoma; Neoplasms; Ovarian Neoplasms; Drug-Related Side Effects and Adverse Reactions; Head and Neck Neoplasms; Solid tumours; Biliary Tract Neoplasms; Carcinoma, Renal Cell; Stomach Neoplasms; Thoracic Neoplasms; Esophageal Neoplasms; Leiomyosarcoma; Small Cell Lung Carcinoma; Carcinoma, Ovarian Epithelial; Lymphoma, Large B-Cell, Diffuse; Sarcoma, Synovial; Lung Diseases, Interstitial; Neuroendocrine Tumors; Liver Diseases; Sarcoma; Medullary thyroid cancer (MTC) Details
Ponatinib Hydrochloride AP24534 hydrochloride; AP24534-HCL; AP24534 HCl; INCB-84344; AP-24534 Approved Ariad Iclusig United States Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic Ariad Pharmaceuticals Inc 2012-12-14 Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Biphenotypic, Acute; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Lymphoma; Leukemia, Myeloid, Acute; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Chronic-Phase; Philadelphia Chromosome; Common Bile Duct Neoplasms; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Medullary thyroid cancer (MTC); Leukemia, Myelogenous, Chronic; Blast Crisis; Glioblastoma; Leukemia, Myelomonocytic, Chronic; Adenocarcinoma of Lung; Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Hematologic Neoplasms; Leukemia, Myeloid, Accelerated Phase; Leukemia; Head and Neck Neoplasms Details
Olverembatinib D-824; GZD-824; APG-1351; GIBH-824; HQP-1351 Approved Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences 耐立克 Mainland China Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Accelerated Phase Guangzhou Shunjian Biomedical Technology Co Ltd 2021-11-25 Leukemia, Myelogenous, Chronic; Solid tumours; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Accelerated Phase; Leukemia, Lymphoid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Chronic-Phase; Gastrointestinal Stromal Tumors Details
Ripretinib DCC-2618 Approved Deciphera Qinlock, 擎乐 United States Gastrointestinal Stromal Tumors Deciphera Pharmaceuticals Llc 2020-05-15 Neoplasms; Mastocytosis, Systemic; Gastrointestinal Stromal Tumors Details
Regorafenib DAST; BAY-73-4506 Approved Bayer AG Stivarga, Resihance United States Colorectal Neoplasms Bayer Healthcare Pharmaceuticals Inc 2012-09-27 Esophageal adenocarcinoma; Osteosarcoma; Sarcoma, Ewing; Bile Duct Neoplasms; Peritoneal Neoplasms; Bone Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Fallopian Tube Neoplasms; Lung Neoplasms; Thyroid Neoplasms; Sarcoma; Leukemia, Myeloid, Acute; Thymoma; Melanoma; Gastrointestinal Neoplasms; Carcinoma, Hepatocellular; Adenocarcinoma; Somatostatinoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Solid tumours; Liver Neoplasms; Carcinoid Tumor; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Islet Cell; Insulinoma; Hemangiosarcoma; Rectal Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms; Pancreatic Neoplasms; Colonic Neoplasms; Neoplasms; Glioblastoma; Carcinoma, Transitional Cell; Glucagonoma; Carcinoma, Adenoid Cystic; Adenoma; Gastrinoma Details
Pazopanib Hydrochloride GSK-786034; GW-786034B; SB-786034; GW-786034 Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Votrient, Patorma United States Carcinoma, Renal Cell; Sarcoma Novartis Pharma Ag 2009-10-19 Uterine Cervical Diseases; Fallopian Tube Neoplasms; Lung Neoplasms; Uterine Neoplasms; Choriocarcinoma; Lymphoma; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Carcinoma, Mucoepidermoid; Gliosarcoma; Genital Neoplasms, Female; Leukemia, Myeloid, Acute; Peritoneal Neoplasms; Brain Neoplasms; Urethral Neoplasms; Medullary thyroid cancer (MTC); Chondrosarcoma, Extraskeletal Myxoid; Prostatic Neoplasms; Osteosarcoma; Neuroblastoma; Sarcoma; Breast Neoplasms; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms; Breast Neoplasms, Male; Neoplasm Metastasis; von Hippel-Lindau Disease; Thyroid Cancer, Papillary; Gastrointestinal Neoplasms; Paraganglioma; Endodermal Sinus Tumor; Neoplasms, Germ Cell and Embryonal; Melanoma; Gastrinoma; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Small Cell; Carcinoma, Embryonal; Germinoma; Glioma; Carcinoma, Neuroendocrine; Epistaxis; Carcinoma, Ovarian Epithelial; Neoplasms; Squamous Cell Carcinoma of Head a Details
Lenvatinib Mesylate ER-203492-00; E-7080; MK-7902 Approved Eisai Co Ltd Lenvima, Lenvima/Kisplyx, 乐卫玛, Kisplyx United States Thyroid Neoplasms Eisai Inc 2015-02-13 Carcinoma, Adenoid Cystic; Thyroid Cancer, Papillary; Melanoma; Paraganglioma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Glioma; Lymphoma; Thyroid Neoplasms; Endometrial Neoplasms; Hepatic Insufficiency; Cholangiocarcinoma; Breast Neoplasms; Osteosarcoma; Solid tumours; Adenocarcinoma, Follicular; Liver Diseases; Neuroendocrine Tumors; Thyroid Carcinoma, Anaplastic; Kidney Diseases; Adenocarcinoma of Lung; Neoplasms; Esophageal Neoplasms; Renal Insufficiency; Carcinoma, Renal Cell; Pheochromocytoma; Ovarian Neoplasms; Liver Neoplasms; Biliary Tract Neoplasms Details
Sorafenib Tosylate NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085 Approved Onyx Pharmaceuticals Inc Nexavar, 多吉美 United States Carcinoma, Renal Cell Bayer Healthcare Pharmaceuticals Inc 2005-12-01 Liver Neoplasms; Leiomyosarcoma; Solid tumours; Recurrence; Ovarian Neoplasms; Leukemia, Erythroblastic, Acute; Rhabdomyosarcoma; Leukemia, Myelogenous, Chronic; Head and Neck Neoplasms; Lymphoma, T-Cell, Peripheral; Fibromatosis, Aggressive; Kidney Neoplasms; Lymphoma, B-Cell, Marginal Zone; Leukemia, Myeloid; Carcinoma, Renal Cell; Histiocytoma, Malignant Fibrous; Carcinoma; Hemangiosarcoma; Carcinoid Tumor; Stomach Neoplasms; Insulinoma; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Islet Cell; Esophageal Neoplasms; Rectal Neoplasms; Vipoma; Myelodysplastic Syndromes; Neoplasms; Wilms Tumor; Thyroid Carcinoma, Anaplastic; Kidney Diseases; Carcinoma, Transitional Cell; Carcinoma, Verrucous; Small Cell Lung Carcinoma; Lymphoma, Large-Cell, Immunoblastic; Salivary Gland Neoplasms; Lymphoma, Large B-Cell, Diffuse; Lymphomatoid Granulomatosis; Multiple Endocrine Neoplasia Type 2a; Glioblastoma; Carcinoma, Ovarian Epithelial; Leukemia, Myelomonocytic, Acute; Colonic Neoplasms; Leukemia, Myelomonocytic, Ch Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
18F-Dasatinib 18F-SKI-249380; [18F]-Fluoro-BMS-354825; [18F]Dasatinib; [18F]SKI-249380; [18F]Fluoro-BMS-354825 Phase 1 Clinical Memorial Sloan Kettering Cancer Center Bone Marrow Neoplasms; Carcinoma; Neoplasms; Sarcoma; Diagnostic agents; Lymphoma; Melanoma Details
Chiauranib CS-2164 Phase 3 Clinical Shenzhen Chipscreen Biosciences Co Ltd Solid tumours; Ovarian Neoplasms; Small Cell Lung Carcinoma; Neoplasms; Triple Negative Breast Neoplasms; Sarcoma; Lymphoma, Non-Hodgkin; Carcinoma, Hepatocellular Details
Telatinib EOC-315; BAY-57-9352 Phase 2 Clinical Bayer AG Solid tumours; Stomach Neoplasms Details
Autologous Human C-Kit Cardiac Stem Cells (CSCs) II (ISCI / University of Miami Miller School of Medicine) Phase 2 Clinical University Of Miami, Elpiscience (Shanghai) Biopharma Ltd Myocardial Infarction; Ventricular Dysfunction, Left Details
THB-001 THB-001 Phase 1 Clinical Novartis Corp Gastrointestinal Diseases; Chronic Urticaria; Respiratory Tract Diseases Details
QBH-196 QBH-196 Phase 1 Clinical Shenyang Pharmaceutical University Solid tumours; Stomach Neoplasms Details
AZD-3229 NB-003; NB003; AZD-3229; AZD3229 Phase 1 Clinical Astrazeneca Turkey Solid tumours; Gastrointestinal Stromal Tumors; Influenza B virus infection Details
TR-64 TR-64 Phase 1 Clinical Tarapeutics Science Inc Solid tumours; Gastrointestinal Stromal Tumors Details
Tafetinib Malate SIM-0702; SIM-1005; SIM-010603 Phase 1 Clinical Jiangsu Simcere Pharmaceutical Co Ltd, Nanjing Yoko Biomedical Co Ltd, Jilin Boda Pharmaceutical Co Ltd Neoplasms Details
Imatinib dry powder inhalation (Aerovate Therapeutics) AV-101(Aerovate Therapeutics) Phase 3 Clinical Aerovate Therapeutics Inc Pulmonary Arterial Hypertension Details
Opelkibart elmanitin MGTA-117 Phase 2 Clinical Heidelberg, Magenta Therapeutics Inc Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
GS-0174 GS-0174 Phase 1 Clinical Forty Seven Inc Hematologic Neoplasms Details
Sitravatinib MG-91516; MGCD-516; IND-155305; MG-516 Phase 3 Clinical Mirati Therapeutics Inc Breast Neoplasms; Carcinoma, Hepatocellular; Gastrointestinal Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Mouth Neoplasms; Endometrial Neoplasms; Carcinoma, Squamous Cell; Esophageal Squamous Cell Carcinoma; Ureteral Neoplasms; Hepatic Insufficiency; Solid tumours; Liposarcoma; Uveal melanoma; Lung Diseases; Carcinoma, Transitional Cell; Triple Negative Breast Neoplasms; Neoplasms; Carcinoma; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Biliary Tract Neoplasms; Kidney Neoplasms Details
T-1301 T-1301; DBPR-216 Phase 1 Clinical Taivex Therapeutics Corp Solid tumours; Lymphoma Details
AGX-0073 AGX-0073 Phase 1 Clinical Shanghai Aojian Biological Technology Co Ltd Solid tumours Details
Sorafenib/MG-005 MG-D-1509; MGD-1509 Tri-Service General Hospital, Metagone Biotech Inc Details
Bezuclastinib PLX-9486; CGT-9486 Phase 3 Clinical Daiichi Sankyo Co Ltd Hematologic Neoplasms; Mastocytosis, Systemic; Leukemia, Mast-Cell; Gastrointestinal Stromal Tumors; Neoplasm Metastasis; Mastocytosis Details
Sorafenib Tosylate/Comekibart MG-D-1609 Phase 2 Clinical Metagone Biotech Inc Solid tumours Details
Barzolvolimab CDX-0159 Phase 2 Clinical Yale University, University Of Toronto - St. George Campus Chronic Urticaria; Skin Diseases; Eosinophilic Esophagitis; Urticaria; Prurigo Details
CDX-0158 CDX-0158; KTN-0158 Phase 1 Clinical Yale University, University Of Toronto - St. George Campus Neoplasms Details
NMS-03592088 NMS-P088; NMS-03592088 Phase 2 Clinical Nerviano Medical Sciences Srl Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
Briquilimab AMG-191; JSP-191 Phase 2 Clinical Amgen Inc Primary Immunodeficiency Diseases; Myelodysplastic Syndromes; Chronic Urticaria; Severe Combined Immunodeficiency; Granulomatous Disease, Chronic; Leukemia, Myeloid, Acute; Anemia, Sickle Cell; Immunologic Deficiency Syndromes Details

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