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Your Position: Home > CD117

CD117

CD117 Molecule Information

Name:Stem cell growth factor receptor
Target Synonym:EC 2.7.10,EC:2.7.10.1,MASTC,Mast/stem cell growth factor receptor Kit,PBT,Piebald trait protein,Tyrosine-protein kinase Kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog,KIT Proto-Oncogene, Receptor Tyrosine Kinase,KIT Proto-Oncogene Recep
Number of Launched Drugs:15
Number of Drugs in Clinical Trials:13
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CD7-H5255 Human Human CD117 / c-kit Protein, Fc Tag
CD7-H5255-structure
CD7-H5255-sds
CD7-H5255-elisa_1
CD7-H52H4 Human Human CD117 / c-kit Protein, His Tag
CD7-H52H4-structure
CD7-H52H4-sds
CD7-H52H4-elisa_1

CD117 Part of Bioactivity data

CD7-H52H4-ELISA
Human CD117, His TagHuman CD117, His Tag (Cat. No. CD7-H52H4) ELISA bioactivity

Immobilized Human CD117, His Tag (Cat. No. CD7-H52H4) at 2 μg/mL (100 μL/well) can bind Biotinylated Human SCF, Avitag,His Tag (Cat. No. SCF-H82E1) with a linear range of 0.5-8 ng/mL (QC tested).

Protocol
CD7-H5255-ELISA
Human CD117, Fc TagHuman CD117, Fc Tag (Cat. No. CD7-H5255) ELISA bioactivity

Immobilized ActiveMax® Human SCF, Tag Free (Cat. No. SCF-H4212) at 2 μg/mL (100 μL/well) can bind Human CD117, Fc Tag (Cat. No. CD7-H5255) with a linear range of 0.5-4 ng/mL (QC tested).

Protocol

CD117 Molecule Synonym Name

CD117,SCFR,c-Kit,KIT

CD117 Molecule Background

Mast/stem cell growth factor receptor Kit (c-Kit), a member of the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily, is also known as piebald trait protein (PBT), p145 c-kit, tyrosine-protein kinase Kit and CD117,which contains five Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. CD117 acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, CD117 can activate several signaling pathways. Furthermore, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B.

CD117 References

CD117 Related Molecule

SCF

CD117 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Ripretinib DCC-2618 Approved Deciphera Qinlock Canada Gastrointestinal Stromal Tumors s:29:"Deciphera Pharmaceuticals Llc"; 2020-05-15 Mastocytosis, Systemic; Gastrointestinal Stromal Tumors Details
Ancestim AMJ-9302 Approved Amgen Inc Stemgen N; Hematopoietic stem cell transplantation (HSCT) Details
Avapritinib BLU-285; CS-3007 Approved Blueprint Medicines Corporation Ayvakyt, Ayvakit EU Gastrointestinal Stromal Tumors s:36:"Blueprint Medicines (Netherlands) Bv"; 2020-01-09 Mastocytosis, Systemic; Leukemia, Mast-Cell; Gastrointestinal Stromal Tumors Details
Ponatinib Hydrochloride AP-24534; INCB-84344; AP24534 HCl; AP24534-HCL; AP24534 hydrochloride Approved Ariad Iclusig Japan Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic, BCR-ABL Positive s:22:"Otsuka Holdings Co Ltd"; 2012-12-14 Leukemia; Leukemia, Myeloid, Accelerated Phase; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Solid tumours; Hematologic Neoplasms; Blast Crisis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Chronic-Phase; Philadelphia Chromosome; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute; Lymphoma; Leukemia, Biphenotypic, Acute Details
Midostaurin PKC-412; PKC-412A; CGP-41231; CGP-41251 Approved Novartis Pharma Ag Rydapt EU Leukemia, Myeloid, Acute; Mastocytosis s:22:"Novartis Europharm Ltd"; 2017-04-28 Hematologic Neoplasms; Leukemia; Mastocytosis, Systemic; Leukemia, Mast-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Mastocytosis Details
Cabozantinib S-malate XL-184; BMS-907351 Approved Exelixis Inc Cometriq, Cabometyx Japan Carcinoma, Renal Cell s:6:"Takeda"; 2012-11-29 Solid tumours; Stomach Neoplasms; Carcinoma, Renal Cell; Pain; Esophageal Neoplasms; Kidney Diseases; Glioblastoma; Prostatic Neoplasms; Colorectal Neoplasms; Hepatic Insufficiency; Astrocytoma; Thyroid Neoplasms; Lymphoma; Carcinoma, Neuroendocrine; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
Imatinib mesylate CTI-571; QTI-571; STI-571; CGP-57148; CGP-57148B Approved Novartis Pharma Ag Gleevec/Glivec, 格列卫, Glivec, Ruvise, glivic, Gleevec United States Precursor Cell Lymphoblastic Leukemia-Lymphoma s:18:"Novartis Pharma Ag"; 2001-05-10 Chordoma; Myelodysplastic-Myeloproliferative Diseases; Acute Lung Injury; Prostatic Diseases; Leukemia, Myeloid, Acute; Urogenital Neoplasms; Leukemia, Myeloid, Chronic-Phase; Gastrointestinal Stromal Tumors; Neurofibrosarcoma; Prostatic Neoplasms; Pulmonary Arterial Hypertension; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Chronic eosinophilic leukemia (CEL); Leukemia; Myelodysplastic Syndromes; Dermatofibrosarcoma; Mastocytosis, Systemic; Leukemia, Myelomonocytic, Chronic; Glioblastoma; Genital Neoplasms, Male; Abdominal Neoplasms; Rhinitis, Allergic, Seasonal; Hypereosinophilic Syndrome; Genital Diseases, Male; Leukemia, Myelogenous, Chronic, BCR-ABL Positive Details
Pexidartinib PLX-3397 Approved Daiichi Sankyo Co Ltd Turalio United States Giant Cell Tumor of Tendon Sheath s:18:"Daiichi Sankyo Inc"; 2019-08-02 Giant Cell Tumor of Tendon Sheath; Solid tumours; Synovitis, Pigmented Villonodular; Hodgkin Disease; Arthritis, Rheumatoid; Glioblastoma; Giant Cell Tumors; Prostatic Neoplasms; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute Details
Sorafenib Tosylate NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085 Approved Onyx Pharmaceuticals Inc 多吉美, Nexavar United States Thyroid Neoplasms s:14:"Bayer Hlthcare"; 2005-12-01 Liver Diseases; Melanoma; Neoplasm Metastasis; Fasting; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Lung Neoplasms; Thyroid Neoplasms; Hepatitis C; Hepatitis B; Breast Neoplasms; Liver Neoplasms; Neoplasms; Kidney Diseases; Pancreatic Neoplasms; Carcinoma; Carcinoma, Renal Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Ovarian Neoplasms; Kidney Neoplasms; Solid tumours Details
Pazopanib Hydrochloride GW-786034; SB-786034; GSK-786034; GW-786034B Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Patorma, Votrient Mainland China Carcinoma, Renal Cell s:26:"Novartis Pharma Schweiz Ag"; 2009-10-19 Osteosarcoma; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Melanoma; Carcinoma, Hepatocellular; Fallopian Tube Neoplasms; Glioma; Uterine Cervical Diseases; Colorectal Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Ovarian Neoplasms; Breast Neoplasms; Sarcoma; Small Cell Lung Carcinoma; Carcinoma, Ovarian Epithelial; Hemangiosarcoma; Carcinoma, Renal Cell; Solid tumours; Uterine Diseases; Chondrosarcoma; Telangiectasia, Hereditary Hemorrhagic Details
Dasatinib Hydrate BMS-354825; NSC-732517 Approved Bristol-Myers Squibb Company 施达赛, Spricel, Sprycel, Spraysel Mainland China Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic, BCR-ABL Positive s:32:"Bristol-Myers Squibb Pharma Eeig"; 2006-06-28 Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Accelerated Phase; Leukemia; Leukemia, Myeloid; Leukemia, Lymphoid; Myelodysplastic Syndromes; Scleroderma, Systemic; Blast Crisis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Breast Neoplasms; Leukemia, Myeloid, Chronic-Phase; Leukemia, Myeloid, Acute; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
Sunitinib Malate SU-11248; SU-010398; PHA-290940; PNU-290940; PHA-290940AD; PNU-290940AD; SU-011248-L-malate salt; GB-102 Approved Pfizer Pharmaceuticals Ltd (China) 索坦, Sutent Japan Pancreatic neuroendocrine tumors (pNET) s:10:"Pfizer Inc"; 2006-01-26 Prostatic Neoplasms; Retinal Vein Occlusion; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Urogenital Neoplasms; Urologic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Breast Neoplasms; Diabetic macular oedema; Kidney Neoplasms; Urologic Diseases; Neuroendocrine Tumors; Kidney Diseases; Pancreatic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Stomach Neoplasms; Carcinoma, Islet Cell; Carcinoma, Renal Cell; Solid tumours; Liver Neoplasms Details
Regorafenib Monohydrate BAY-73-4506; DAST Approved Bayer Ag Stivarga, Resihance Mainland China Gastrointestinal Stromal Tumors s:15:"Bayer Pharma Ag"; 2012-09-27 Solid tumours; Rectal Neoplasms; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Carcinoma, Hepatocellular; Gastrointestinal Neoplasms Details
Lenvatinib Mesylate ER-203492-00; E-7080 Approved Eisai Co Ltd Kisplyx, Lenvima, Lenvima/Kisplyx, 乐卫玛 Mainland China Carcinoma, Hepatocellular s:16:"Eisai Europe Ltd"; 2015-02-13 Solid tumours; Liver Neoplasms; Biliary Tract Neoplasms; Ovarian Neoplasms; Carcinoma, Renal Cell; Adenocarcinoma of Lung; Thyroid Carcinoma, Anaplastic; Kidney Diseases; Osteosarcoma; Hepatic Insufficiency; Thyroid Neoplasms; Lymphoma; Endometrial Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Melanoma Details
Anlotinib Dihydrochloride AL-3818 Approved Advenchen Laboratories, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 福可维 Mainland China Small Cell Lung Carcinoma s:47:"Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd"; 2018-05-08 Gallbladder Neoplasms; Gastrointestinal Stromal Tumors; Peritoneal Neoplasms; Colorectal Neoplasms; Bone Neoplasms; Urologic Neoplasms; Endometrial Neoplasms; Thyroid Neoplasms; Esophageal Squamous Cell Carcinoma; Lung Neoplasms; Nasopharyngeal Carcinoma; Sarcoma, Alveolar Soft Part; Fallopian Tube Neoplasms; Carcinoma, Hepatocellular; Melanoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Adenocarcinoma; Osteoma; Gastrointestinal Neoplasms; Carcinoma, Ovarian Epithelial; Biliary Tract Neoplasms; Ovarian Neoplasms; Leiomyosarcoma; Liver Neoplasms; Head and Neck Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Esophageal Neoplasms; Thoracic Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Lymphoma, Large B-Cell, Diffuse; Sarcoma, Synovial; Neuroendocrine Tumors; Sarcoma; Medullary thyroid cancer (MTC); Cholangiocarcinoma; Bile Duct Diseases Details

CD117 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Imatinib mesylate (YD Global Life Science) YD-312 Phase 2 Clinical Yd Global Life Science Diabetic macular oedema Details
QBH-196 QBH-196 Phase 1 Clinical Shenyang Pharmaceutical University Stomach Neoplasms Details
PLX-9486 PLX-9486 Phase 2 Clinical Daiichi Sankyo Co Ltd Gastrointestinal Stromal Tumors Details
KTN-0158 CDX-0159; KTN-0158 Phase 1 Clinical Yale University, University Of Toronto - St. George Campus Neurofibromatoses; Chronic Urticaria; Neoplasms; Skin Diseases; Urticaria; Inflammation Details
Sorafenib/MG-005 MGD-1509 Phase 2 Clinical Metagone Biotech, Tri-Service General Hospital Neoplasms Details
Hydroxychloroquine/Sorafenib Phase 1 Clinical Vg Life Sciences Ovarian Neoplasms Details
AMG-191 AMG-191 Phase 1 Clinical Amgen Inc Severe Combined Immunodeficiency; Inflammation Details
NMS-03592088 NMS-P088; NMS-03592088 Phase 2 Clinical Nerviano Medical Sciences Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
Dovitinib TKI-258; CHIR-258; GFKI-258; CHIR-258LC; NVP-TKI258 Phase 2 Clinical Novartis Pharma Ag Carcinoma, Adenoid Cystic; Carcinoma, Non-Small-Cell Lung; Melanoma; Carcinoma, Hepatocellular; Thyroid Neoplasms; Leukemia, Myeloid, Acute; Endometrial Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Hepatic Insufficiency; Prostatic Neoplasms; Breast Neoplasms; Solid tumours; Adrenocortical Carcinoma; Multiple Myeloma; Pancreatic Neoplasms; Glioblastoma; Adenocarcinoma, Scirrhous; Carcinoma; Carcinoma, Renal Cell; Stomach Neoplasms; Liver Neoplasms; Linitis Plastica; Stomach Diseases Details
Tafetinib Malate SIM-0702; SIM-1005; SIM-010603 Phase 1 Clinical Jiangsu Xiansheng Pharmaceutical Co Ltd, Nanjing Yoko Biomedical Co Ltd, Jilin Boda Pharmaceutical Co Ltd Solid tumours; Neoplasms Details
Telatinib EOC-315; BAY-57-9352 Phase 2 Clinical Bayer Ag Solid tumours; Stomach Neoplasms Details

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