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Brief Information

Name:Stem cell growth factor receptor
Target Synonym:EC 2.7.10,EC:,MASTC,KIT Proto-Oncogene Receptor Tyrosine Kinase,V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene-Like Protein,p145 c-kit,SCFR,KIT,Proto-Oncogene C-Kit,Proto-Oncogene Tyrosine-Protein Kinase Kit,Soluble KIT Variant 1,C-Kit Protooncogene,CD117 Antigen,Piebald Trait,EC,C-Kit,CD117,Proto-Oncogene Proteins c-kit,Mast/stem cell growth factor receptor Kit,PBT,Piebald trait protein,Tyrosine-protein kinase Kit,KIT Proto-Oncogene, Receptor Tyrosine Kinase,v-kit Hardy-
Number of Launched Drugs:16
Number of Drugs in Clinical Trials:28
Lastest Research Phase:Approved

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Part of Bioactivity data

 CD117 SPR

Biotinylated Human SCF, Avitag,His Tag (Cat. No. SCF-H82E1) captured on Biotin CAP-Series S Sensor Chip can bind Human CD117, His Tag (Cat. No. CD7-H52H4) with an affinity constant of 0.236 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).


Immobilized Human SCF protein, His Tag at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD117, His,Avitag (Cat. No. CD7-H82E6) with a linear range of 0.02-0.625 μg/mL (QC tested).

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Synonym Name



Mast/stem cell growth factor receptor Kit (c-Kit), a member of  the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily, is also known as piebald trait protein (PBT), p145 c-kit, tyrosine-protein kinase Kit and CD117,which contains five Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. CD117 acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, CD117 can activate several signaling pathways. Furthermore, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B.

Clinical and Translational Updates

Related Molecule


Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Anlotinib Dihydrochloride AL-3818 Approved Advenchen Laboratories Llc, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 福可维 Mainland China Carcinoma, Non-Small-Cell Lung Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 2018-05-08 Sarcoma, Alveolar Soft Part; Bile Duct Diseases; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Peritoneal Neoplasms; Hepatic Insufficiency; Bone Neoplasms; Urologic Neoplasms; Fallopian Tube Neoplasms; Thyroid Neoplasms; Endometrial Neoplasms; Medullary thyroid cancer (MTC); Gallbladder Neoplasms; Glioma; Lung Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Osteoma; Melanoma; Carcinoma, Hepatocellular; Carcinoma, Ovarian Epithelial; Leiomyosarcoma; Solid tumours; Drug-Related Side Effects and Adverse Reactions; Biliary Tract Neoplasms; Head and Neck Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Thoracic Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms; Small Cell Lung Carcinoma; Neoplasms; Lymphoma, Large B-Cell, Diffuse; Sarcoma, Synovial; Neuroendocrine Tumors; Lung Diseases, Interstitial; Liver Diseases; Sarcoma; Nasopharyngeal Carcinoma Details
Imatinib mesylate CGP-57148B; CGP-57148; STI-571; QTI-571; CTI-571; VR325; AER-901; YD-312; TNX-201 Approved Novartis Pharma Ag glivic, 格列卫, Gleevec, Ruvise, Glivec, Gleevec/Glivec EU Leukemia, Myelogenous, Chronic Novartis Europharm Ltd 2001-05-10 Leukemia, Myelogenous, Chronic; Hypereosinophilic Syndrome; Ovarian Neoplasms; Leukemia; Ovarian germ cell tumor; Leukemia, Myeloid, Accelerated Phase; Solid tumours; Hematopoietic stem cell transplantation (HSCT); Fibrosarcoma; Head and Neck Neoplasms; Hypertension, Pulmonary; Neoplasm, Residual; Genital Diseases, Male; Diabetes Mellitus, Type 1; Loiasis; Lymphoma, B-Cell, Marginal Zone; Abdominal Neoplasms; Leukemia, Hairy Cell; Desmoplastic Small Round Cell Tumor; Polycythemia Vera; Rhinitis, Allergic, Seasonal; Histiocytoma, Malignant Fibrous; Genital Neoplasms, Male; Macular Edema; Rectal Neoplasms; Stomach Neoplasms; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Leukemia, Myelomonocytic, Chronic; Colonic Neoplasms; Immunoglobulin Light-chain Amyloidosis; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Carcinoma, Ovarian Epithelial; Small Cell Lung Carcinoma; Mastocytosis, Systemic; Myelodysplastic Syndromes; Dermatofibrosarcoma; Scleroderma, Systemic; Plasmacytoma; Skin Neoplasms; Leukem Details
Lenvatinib Mesylate MK-7902; ER-203492-00; E-7080 Approved Eisai Co Ltd Kisplyx, Lenvima, Lenvima/Kisplyx, 乐卫玛 United States Thyroid Neoplasms Eisai Inc 2015-02-13 Carcinoma, Adenoid Cystic; Paraganglioma; Melanoma; Thyroid Cancer, Papillary; Carcinoma, Hepatocellular; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Glioma; Lymphoma; Endometrial Neoplasms; Thyroid Neoplasms; Hepatic Insufficiency; Breast Neoplasms; Cholangiocarcinoma; Osteosarcoma; Solid tumours; Neuroendocrine Tumors; Adenocarcinoma, Follicular; Liver Diseases; Thyroid Carcinoma, Anaplastic; Adenocarcinoma of Lung; Kidney Diseases; Neoplasms; Pheochromocytoma; Esophageal Neoplasms; Renal Insufficiency; Carcinoma, Renal Cell; Liver Neoplasms; Ovarian Neoplasms; Biliary Tract Neoplasms Details
Regorafenib DAST; BAY-73-4506 Approved Bayer AG Stivarga, Resihance United States Colorectal Neoplasms Bayer Healthcare Pharmaceuticals Inc 2012-09-27 Fallopian Tube Neoplasms; Osteosarcoma; Sarcoma, Ewing; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Peritoneal Neoplasms; Bone Neoplasms; Bile Duct Neoplasms; Thymoma; Thyroid Neoplasms; Leukemia, Myeloid, Acute; Gastrinoma; Lung Neoplasms; Esophageal adenocarcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Melanoma; Gastrointestinal Neoplasms; Somatostatinoma; Adenocarcinoma; Neoplasm Metastasis; Meningioma; Neoplasms; Solid tumours; Ovarian Neoplasms; Rectal Neoplasms; Carcinoma, Renal Cell; Hemangiosarcoma; Carcinoid Tumor; Insulinoma; Carcinoma, Islet Cell; Stomach Neoplasms; Esophageal Neoplasms; Liver Neoplasms; Carcinoma, Transitional Cell; Colonic Neoplasms; Pancreatic Neoplasms; Glioblastoma; Carcinoma, Ovarian Epithelial; Adenoma; Glucagonoma; Carcinoma, Adenoid Cystic; Sarcoma Details
Avapritinib BLU-285; CS-3007 Approved Blueprint Medicines Corp Ayvakyt, Ayvakit, 泰吉华 United States Gastrointestinal Stromal Tumors Blueprint Medicines Corp 2020-01-09 Solid tumours; Hematologic Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Mastocytosis, Systemic; Central Nervous System Neoplasms; Leukemia, Mast-Cell; Sarcoma; Breast Neoplasms; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Lung Neoplasms; Melanoma; Adenocarcinoma Details
Vorolanib X-82; EYP-1901; CM-082 Approved Tyrogenex Inc 伏美纳 Mainland China Carcinoma, Renal Cell Betta Pharmaceuticals Co Ltd 2023-06-07 Diabetic macular oedema; Carcinoma, Non-Small-Cell Lung; Melanoma; Macular Degeneration; Carcinoma, Hepatocellular; Diabetic Retinopathy; Choroidal Neovascularization; Adenocarcinoma; Retinal Degeneration; Leukemia, Myeloid, Acute; Eye Diseases; Solid tumours; Wet Macular Degeneration; Retinal Diseases; Small Cell Lung Carcinoma; Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Carcinoma, Renal Cell; Kidney Neoplasms Details
Ripretinib DCC-2618 Approved Deciphera Qinlock, 擎乐 United States Gastrointestinal Stromal Tumors Deciphera Pharmaceuticals Llc 2020-05-15 Neoplasms; Mastocytosis, Systemic; Gastrointestinal Stromal Tumors Details
Olverembatinib GZD-824; APG-1351; GIBH-824; HQP-1351; D-824 Approved Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences 耐立克 Mainland China Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Accelerated Phase Guangzhou Shunjian Biomedical Technology Co Ltd 2021-11-25 Solid tumours; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid; Leukemia, Myeloid, Accelerated Phase; Leukemia; Leukemia, Lymphoid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Chronic-Phase; Gastrointestinal Stromal Tumors Details
Ponatinib Hydrochloride AP24534 hydrochloride; AP24534-HCL; AP24534 HCl; INCB-84344; AP-24534 Approved Ariad Iclusig United States Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic Ariad Pharmaceuticals Inc 2012-12-14 Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Biphenotypic, Acute; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Lymphoma; Leukemia, Myeloid, Acute; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Chronic-Phase; Philadelphia Chromosome; Common Bile Duct Neoplasms; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Medullary thyroid cancer (MTC); Leukemia, Myelogenous, Chronic; Blast Crisis; Glioblastoma; Leukemia, Myelomonocytic, Chronic; Adenocarcinoma of Lung; Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Hematologic Neoplasms; Leukemia, Myeloid, Accelerated Phase; Leukemia; Head and Neck Neoplasms Details
Sunitinib Malate PNU-290940AD; PHA-290940AD; SCAI-003; GB-102; PNU-290940; SU-011248-L-malate salt; PHA-290940; SU-010398; SU-11248 Approved Pfizer Inc 索坦, Sutent United States Carcinoma, Renal Cell; Gastrointestinal Stromal Tumors Cppi Cv 2006-01-26 Solid tumours; Fibromatosis, Aggressive; Ovarian Neoplasms; Kidney Neoplasms; Leukemia, Myelogenous, Chronic; Head and Neck Neoplasms; Leiomyosarcoma; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; HIV Infections; Leukemia, Myeloid, Accelerated Phase; Leukemia; Fibrosarcoma; Teratoma; Liver Neoplasms; Ependymoma; Lymphoma, T-Cell, Peripheral; Intestinal Neoplasms; Histiocytoma, Malignant Fibrous; Carcinoma, Renal Cell; Hemangioblastoma; Carcinoma, Islet Cell; Carcinoma; Pheochromocytoma; Stomach Neoplasms; Pelvic Neoplasms; Esophageal Neoplasms; Leukemia, Hairy Cell; Polycythemia Vera; Abdominal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Thoracic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Carcinoma, Ovarian Epithelial; Glioblastoma; Neurofibromatoses; Small Cell Lung Carcinoma; Adenoma, Islet Cell; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Lymphoma, Large B-Cell, Diffuse; Neoplasms; Myelodysplastic Syndromes; Hodgkin Disease; Leukemia, Myelomonocytic, Chronic; Carcinoma, Papil Details
Dasatinib Hydrate NSC-732517; BMS-354825; XS-004 Approved Bristol-Myers Squibb Company 施达赛, Dasynoc, Spricel, Sprycel, Spraysel United States Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic Bristol-Myers Squibb Company 2006-06-28 Primary Myelofibrosis; Hemangiopericytoma; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Waldenstrom Macroglobulinemia; Laryngeal Neoplasms; Lymphoma; Gliosarcoma; Peritoneal Neoplasms; Astrocytoma; Giant Cell Tumor of Bone; Gastrointestinal Stromal Tumors; Sarcoma, Alveolar Soft Part; Leukemia, Myeloid, Chronic-Phase; Sarcoma, Ewing; Lymphoma, Follicular; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Cholangiocarcinoma; Lymphoma, Mantle-Cell; Sarcoma; Neurofibrosarcoma; Breast Neoplasms; Brain Neoplasms; Melanoma; Leukemia, T-Cell; Carcinoma, Hepatocellular; Leukemia, Large Granular Lymphocytic; Adenocarcinoma; Mycosis Fungoides; Heart Arrest; Mastocytosis; Tongue Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Leukemia, Lymphocytic, Chronic, B-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Fallopian Tube Neoplasms; Lymphoma, T-Cell, Cutaneous; Uterine Neoplasms; Burkitt Lymphoma; Neoplasms, Gonadal Tissue; Intraocular Lymphoma; Lymphoma, Large-Cell, Anaplas Details
Pexidartinib PLX-3397 Approved Daiichi Sankyo Co Ltd Turalio United States Giant Cell Tumor of Tendon Sheath Daiichi Sankyo Inc 2019-08-02 Prostatic Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma; Neoplasm Metastasis; Leukemia, Myeloid, Acute; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Neurofibrosarcoma; Giant Cell Tumors; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Neurofibroma, Plexiform; Sarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours; Breast Neoplasms; Neoplasms; Arthritis, Rheumatoid; Hodgkin Disease; Glioblastoma; Pancreatic Neoplasms; Synovitis, Pigmented Villonodular; Squamous Cell Carcinoma of Head and Neck; Leukemia, Promyelocytic, Acute; Ovarian Neoplasms; Giant Cell Tumor of Tendon Sheath Details
Pazopanib Hydrochloride GSK-786034; GW-786034B; SB-786034; GW-786034 Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Votrient, Patorma United States Carcinoma, Renal Cell; Sarcoma Novartis Pharma Ag 2009-10-19 Uterine Cervical Diseases; Fallopian Tube Neoplasms; Lung Neoplasms; Uterine Neoplasms; Choriocarcinoma; Lymphoma; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Carcinoma, Mucoepidermoid; Gliosarcoma; Genital Neoplasms, Female; Leukemia, Myeloid, Acute; Peritoneal Neoplasms; Brain Neoplasms; Urethral Neoplasms; Medullary thyroid cancer (MTC); Chondrosarcoma, Extraskeletal Myxoid; Prostatic Neoplasms; Osteosarcoma; Neuroblastoma; Sarcoma; Breast Neoplasms; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms; Breast Neoplasms, Male; Neoplasm Metastasis; von Hippel-Lindau Disease; Thyroid Cancer, Papillary; Gastrointestinal Neoplasms; Paraganglioma; Endodermal Sinus Tumor; Neoplasms, Germ Cell and Embryonal; Melanoma; Gastrinoma; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Small Cell; Carcinoma, Embryonal; Germinoma; Glioma; Carcinoma, Neuroendocrine; Epistaxis; Carcinoma, Ovarian Epithelial; Neoplasms; Squamous Cell Carcinoma of Head a Details
Cabozantinib S-malate XL-184; BMS-907351 Approved Exelixis Inc Cometriq, Cabometyx United States Carcinoma, Neuroendocrine; Thyroid Neoplasms Exelixis Inc 2012-11-29 Urethral Neoplasms; Leukemia, Myeloid, Acute; Thyroid Neoplasms; Gliosarcoma; Colorectal Neoplasms; Astrocytoma; Hepatic Insufficiency; Peritoneal Neoplasms; Bile Duct Neoplasms; Sarcoma, Clear Cell; Uterine Neoplasms; Adenocarcinoma, Clear Cell; Sarcoma, Ewing; Carcinoma, Adenosquamous; Breast Neoplasms; Neurofibroma, Plexiform; Osteosarcoma; Prostatic Neoplasms; Sarcoma; Medullary thyroid cancer (MTC); Carcinoma, Hepatocellular; Melanoma; Paraganglioma; Meningioma; Neoplasms, Germ Cell and Embryonal; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Carcinoma, Endometrioid; Thyroid Cancer, Papillary; Brain Neoplasms; Carcinoma, Neuroendocrine; Sarcoma, Alveolar Soft Part; Lymphoma; Fallopian Tube Neoplasms; Brain metastases; Glioma; Endometrial Neoplasms; Carcinoma, Squamous Cell; Carcinoid Tumor; Glioblastoma; Skin Neoplasms; Neoplasms; Carcinoma, Papillary; Hepatoblastoma; Pheochromocytoma; Pain; Rejection of liver transplantation; Carcinoma, Renal Cell; Pancreatic neuroendocrine tumors Details
Sorafenib Tosylate NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085 Approved Onyx Pharmaceuticals Inc Nexavar, 多吉美 United States Carcinoma, Renal Cell Bayer Healthcare Pharmaceuticals Inc 2005-12-01 Liver Neoplasms; Kidney Neoplasms; Recurrence; Ovarian Neoplasms; Leukemia, Myelogenous, Chronic; Lymphoma, T-Cell, Peripheral; Leukemia, Erythroblastic, Acute; Rhabdomyosarcoma; Lymphoma, B-Cell, Marginal Zone; Fibromatosis, Aggressive; Head and Neck Neoplasms; Solid tumours; Leiomyosarcoma; Leukemia, Myeloid; Carcinoma, Renal Cell; Carcinoma; Vipoma; Esophageal Neoplasms; Hemangiosarcoma; Squamous Cell Carcinoma of Head and Neck; Rectal Neoplasms; Carcinoid Tumor; Histiocytoma, Malignant Fibrous; Carcinoma, Islet Cell; Insulinoma; Stomach Neoplasms; Neoplasms; Kidney Diseases; Small Cell Lung Carcinoma; Carcinoma, Transitional Cell; Carcinoma, Verrucous; Thyroid Carcinoma, Anaplastic; Myelodysplastic Syndromes; Glioblastoma; Pancreatic Neoplasms; Leukemia, Myelomonocytic, Chronic; Carcinoma, Ovarian Epithelial; Leukemia, Myelomonocytic, Acute; Wilms Tumor; Lymphomatoid Granulomatosis; Colonic Neoplasms; Hypertension, Portal; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Immunoblastic; Multiple Endo Details
Midostaurin PKC-412; PKC-412A; CGP-41231; CGP-41251 Approved Novartis Pharma Ag Rydapt United States Mastocytosis, Systemic; Leukemia, Mast-Cell; Hematologic Neoplasms; Leukemia, Myeloid, Acute Novartis Pharmaceuticals Corp 2017-04-28 Leukemia; Hematologic Neoplasms; Mastocytosis, Systemic; Myelodysplastic Syndromes; Leukemia, Mast-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Mastocytosis Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Chiauranib CS-2164; CS2164 Phase 3 Clinical Shenzhen Chipscreen Biosciences Co Ltd Solid tumours; Ovarian Neoplasms; Neoplasms; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Sarcoma; Lymphoma, Non-Hodgkin; Carcinoma, Hepatocellular Details
Bezuclastinib PLX-9486; CGT-9486 Phase 3 Clinical Daiichi Sankyo Co Ltd Hematologic Neoplasms; Mastocytosis, Systemic; Leukemia, Mast-Cell; Gastrointestinal Stromal Tumors; Neoplasm Metastasis; Mastocytosis Details
oral enteric coated imatinib (Tenax Therapeutics) TNX-201 (Tenax Therapeutics) Phase 3 Clinical PH Precision Med Pulmonary Arterial Hypertension Details
Sitravatinib MG-91516; MGCD-516; IND-155305; MG-516 Phase 3 Clinical Mirati Therapeutics Inc Breast Neoplasms; Carcinoma, Hepatocellular; Gastrointestinal Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Mouth Neoplasms; Endometrial Neoplasms; Carcinoma, Squamous Cell; Esophageal Squamous Cell Carcinoma; Lung Neoplasms; Ureteral Neoplasms; Hepatic Insufficiency; Solid tumours; Liposarcoma; Uveal melanoma; Lung Diseases; Carcinoma, Transitional Cell; Neoplasms; Triple Negative Breast Neoplasms; Carcinoma; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Biliary Tract Neoplasms; Kidney Neoplasms Details
Imatinib dry powder inhalation (Aerovate Therapeutics) AV-101(Aerovate Therapeutics) Phase 3 Clinical Aerovate Therapeutics Inc Pulmonary Arterial Hypertension Details
Autologous Human C-Kit Cardiac Stem Cells (CSCs) II (ISCI / University of Miami Miller School of Medicine) Phase 2 Clinical University Of Miami, Elpiscience (Shanghai) Biopharma Ltd Myocardial Infarction; Ventricular Dysfunction, Left Details
NMS-03592088 NMS-P088; NMS-03592088 Phase 2 Clinical Nerviano Medical Sciences Srl Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
Telatinib EOC-315; BAY-57-9352 Phase 2 Clinical Bayer AG Solid tumours; Stomach Neoplasms Details
Barzolvolimab CDX-0159 Phase 2 Clinical Yale University, University Of Toronto - St. George Campus Chronic Urticaria; Skin Diseases; Eosinophilic Esophagitis; Prurigo; Urticaria Details
Briquilimab JSP191; JSP-191; AMG-191 Phase 2 Clinical Amgen Inc, National Heart, Lung And Blood Institute, Stanford University Primary Immunodeficiency Diseases; Chronic Urticaria; Myelodysplastic Syndromes; Severe Combined Immunodeficiency; Granulomatous Disease, Chronic; Leukemia, Myeloid, Acute; Immunologic Deficiency Syndromes; Anemia, Sickle Cell Details
Sorafenib Tosylate/Comekibart MG-D-1609 Phase 2 Clinical Metagone Biotech Inc Solid tumours Details
Opelkibart elmanitin MGTA-117 Phase 2 Clinical Heidelberg Pharma AG Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
18F-Dasatinib 18F-SKI-249380; [18F]-Fluoro-BMS-354825; [18F]Dasatinib; [18F]SKI-249380; [18F]Fluoro-BMS-354825 Phase 1 Clinical Memorial Sloan Kettering Cancer Center Bone Marrow Neoplasms; Carcinoma; Neoplasms; Sarcoma; Diagnostic agents; Lymphoma; Melanoma Details
Tafetinib Malate SIM-0702; SIM-1005; SIM-010603 Phase 1 Clinical Jiangsu Simcere Pharmaceutical Co Ltd, Nanjing Yoko Biomedical Co Ltd, Jilin Boda Pharmaceutical Co Ltd Neoplasms Details
QBH-196 QBH-196 Phase 1 Clinical Shenyang Pharmaceutical University Solid tumours; Stomach Neoplasms Details
ETN-101 ETN101; ETN-101; MBP-11901 Phase 1 Clinical Etnova Therapeutics Corp Liver Neoplasms; Carcinoma, Hepatocellular Details
NN-2101 NN-2101 Phase 1 Clinical Novelty Nobility Inc Retinal Diseases; Diabetic macular oedema; Wet Macular Degeneration; Diabetic Retinopathy; Retinal Vein Occlusion Details
THB-001 THB-001 Phase 1 Clinical Novartis Corp Gastrointestinal Diseases; Chronic Urticaria; Respiratory Tract Diseases Details
T-1301 T-1301; DBPR-216 Phase 1 Clinical Taivex Therapeutics Corp Solid tumours; Lymphoma Details
GS-0174 GS-0174 Phase 1 Clinical Forty Seven Inc Hematologic Neoplasms Details
CDX-0158 CDX-0158; KTN-0158 Phase 1 Clinical Yale University, University Of Toronto - St. George Campus Neoplasms Details
TR-64 TR-64 Phase 1 Clinical Tarapeutics Science Inc Solid tumours; Gastrointestinal Stromal Tumors Details
AZD-3229 NB-003; NB003; AZD-3229; AZD3229 Phase 1 Clinical Astrazeneca Turkey Solid tumours; Gastrointestinal Stromal Tumors; Influenza B virus infection Details
AGX-0073 AGX-0073 Phase 1 Clinical Shanghai Aojian Biological Technology Co Ltd Solid tumours Details
Sorafenib/MG-005 MGD-1509; MG-D-1509 Tri-Service General Hospital, Metagone Biotech Inc Details

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