Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > IL-12 R beta 1

IL-12 R beta 1

Brief Information

Name:Interleukin-12 receptor
Target Synonym:Receptors, Interleukin-12
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:10
Lastest Research Phase:Phase 3 Clinical

Product ListCompare or Buy

ACRO Quality

Part of Bioactivity data

 IL-12 R beta 1 SPR

Human IL-12 R beta 1, Fc Tag (Cat. No. ILB-H5255) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210) with an affinity constant of 2.06 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

 IL-12 R beta 1 BLI

Loaded Biotinylated Human IL-12 R beta 1, His,Avitag (Cat. No. ILB-H52E1) on SA Biosensor, can bind ActiveMax® Human IL-12 ,Tag Free (Cat. No. IL2-H5210) with an affinity constant of 1.7 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

IL-12 R beta 1,IL12RB1,CD212,IL12R,IL12RB,IL-12RB1


The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12 R beta 1(Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
KLT-1101 KLT-1101 Phase 2 Clinical Kang Litai Pharmaceutical Co Ltd Solid tumours; Leukopenia; Thrombocytopenia; Sarcoma, Kaposi Details
CLN-617 CLN-617 Phase 1 Clinical Cullinan Oncology Solid tumours Details
GEN-1 phIL-12-005/PPC; GEN-1; EGEN-001; IMNN-001 Phase 2 Clinical Expression Genetics Cystadenocarcinoma; Ovarian Neoplasms; Cystadenocarcinoma, Serous; Carcinoma; Carcinoma, Ovarian Epithelial; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Endometrioid Details
SON-1010 SON-1010 Phase 2 Clinical Sonnet Biotherapeutics Inc Ovarian Neoplasms; Solid tumours Details
RTX-224 RTX-224 Phase 2 Clinical Rubius Therapeutics Inc Skin Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Carcinoma, Non-Small-Cell Lung Details
Ustekinumab biosimilar (Samsung Bioepis) SB-17; SB17 Phase 3 Clinical Samsung Bioepis Co Ltd Psoriasis; Plaque psoriasis Details
KB-707 KB-707; KB707 Phase 1 Clinical Krystal Biotech Inc Skin Melanoma; Carcinoma, Basal Cell; Neoplasms; Osteosarcoma; Carcinoma, Squamous Cell; Melanoma Details
Edodekin alfa RO 247472; YM 01C Phase 2 Clinical Wistar Institute, Valeant, F. Hoffmann-La Roche Ltd Breast Neoplasms; Leishmaniasis; Bacterial Infections; Melanoma; Sarcoma, Kaposi; Lymphoma, T-Cell, Cutaneous; Lymphoma, Non-Hodgkin; Lymphoma; Carcinoma, Squamous Cell; Hepatitis C; Asthma; Solid tumours; Hepatitis B; Graft vs Host Disease; Carcinoma, Ovarian Epithelial; Neoplasms; Malaria; Carcinoma, Renal Cell; Abdominal Neoplasms; Squamous Cell Carcinoma of Head and Neck; HIV Infections Details
ASP-9801 ASP-9801 Phase 1 Clinical Astellas Pharma Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details

This web search service is supported by Google Inc.

Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
+1 888-377-6111
1 Innovation Way, Newark, DE 19711, USA

Leave a message