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Your Position: Home > IL-12 R beta 1

IL-12 R beta 1

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Cat. No. Species Product Description Structure Purity Feature
ILB-M52E1 Mouse Biotinylated Mouse IL-12 R beta 1 / CD212 Protein, His,Avitag™
ILB-M52E1-structure
ILB-M52E1-sds
ILB-H52E1 Human Biotinylated Human IL-12 R beta 1 / CD212 Protein, His,Avitag™ (MALS verified)
ILB-H52E1-structure
ILB-H52E1-sds
ILB-C52E2 Cynomolgus Biotinylated Cynomolgus IL-12 R beta 1 / CD212 Protein, His,Avitag™
ILB-C52E2-structure
ILB-C52E2-sds
ILB-H5255 Human Human IL-12 R beta 1 / CD212 Protein, Fc Tag
ILB-H5255-structure
ILB-H5255-sds
ILB-H82F7 Human Biotinylated Human IL-12 R beta 1 / CD212 Protein, Fc,Avitag™
ILB-H82F7-structure
ILB-H82F7-sds
ILB-H52H9 Human Human IL-12 R beta 1 / CD212 Protein, His Tag (MALS verified)
ILB-H52H9-structure
ILB-H52H9-sds
ACRO Quality

Part of Bioactivity data

ILB-H5255-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-12 R beta 1, Fc Tag (Cat. No. ILB-H5255) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (Cat. No. IL2-H4210) with an affinity constant of 2.06 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
ILB-H52E1-BLI
IL-12 R beta 1 BLI

Loaded Biotinylated Human IL-12 R beta 1, His,Avitag (Cat. No. ILB-H52E1) on SA Biosensor, can bind ActiveMax® Human IL-12 ,Tag Free (Cat. No. IL2-H5210) with an affinity constant of 1.7 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

IL-12 R beta 1,IL12RB1,CD212,IL12R,IL12RB,IL-12RB1

Background

The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12 R beta 1(Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

Clinical and Translational Updates

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