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IgG4 Fc

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Cat. No. Species Product Description Structure Purity Feature
IG4-H5205 Human Human IgG4 Fc Protein, Tag Free (MALS & SPR verified)
IG4-H5205-structure
IG4-H5205-sds

Part of Bioactivity data

IG4-H5205-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human FCGRT&B2M Heterodimer Protein, His Tag (Cat. No. FCN-H52W7) captured on CM5 Chip via anti-His antibody can bind Human IgG4 Fc, Tag Free (Cat. No. IG4-H5205) with an affinity constant of 0.715 μM as determined in SPR assay (Biacore 8K) (QC tested).

IG4-H5205-MALS-HPLC
Human IgG4 Fc, Tag Free (Cat. No. ) MALS images

The purity of Human IgG4 Fc, Tag Free (Cat. No. IG4-H5205) is more than 95% and the molecular weight of this protein is around 54-66 kDa verified by SEC-MALS.

Bioactivity-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human FCGRT&B2M Heterodimer Protein, His Tag (Cat. No. FCN-H52W7) captured on CM5 Chip via anti-His antibody can bind Human IgG4 Fc, Tag Free (Cat. No. IG4-H5205) with an affinity constant of 0.715 μM as determined in SPR assay (Biacore 8K) (QC tested).

Synonym Name

IGHG4

Background

Immunoglobulin G4 (IgG4) is a member of many immunoglobulin G developed and secreted by effective B cells. In wake of cutting by pepsin, IgG is divided into two F(ab)s with one antigen binding site and a high conserved Fc segment. The Fc segment bears a highly conserved N-glycosylation site. Ig gamma-4 chain Fc region contains two constant regions of IgG4 H chain (CH2, CH3).

Clinical and Translational Updates

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